desipramine has been researched along with Aggression in 43 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The activity of chronic (3 weeks) treatment with the triazolobenzodiazepines, alprazolam and adinazolam, on clonidine- and apomorphine-induced aggression were studied." | 7.67 | Effect of chronic administration of alprazolam and adinazolam on clonidine- or apomorphine-induced aggression in laboratory rodents. ( Baiguerra, G; Kostowski, W; Valzelli, L, 1986) |
| "Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder." | 3.71 | Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder. ( Ferris, CF; Koppel, G; Messenger, T; Rasmussen, MF, 2001) |
| "In previous studies tryptophan and 5-hydroxy-tryptophan (5-HTP) treatments produced opposite effects on aggression and vigilance and differing effects on eating and locomoting in vervet monkeys." | 3.67 | Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems. ( Raleigh, MJ, 1987) |
| "The activity of chronic (3 weeks) treatment with the triazolobenzodiazepines, alprazolam and adinazolam, on clonidine- and apomorphine-induced aggression were studied." | 3.67 | Effect of chronic administration of alprazolam and adinazolam on clonidine- or apomorphine-induced aggression in laboratory rodents. ( Baiguerra, G; Kostowski, W; Valzelli, L, 1986) |
| "Nortriptyline was reported in one study as superior for men with alcohol dependency on mean number of drinking days and on alcohol dependence, but not for severity of alcohol misuse or on the patient's or clinician's rating of drinking." | 2.46 | Pharmacological interventions for antisocial personality disorder. ( Duggan, C; Ferriter, M; Huband, N; Khalifa, N; Lieb, K; Stoffers, J; Völlm, BA, 2010) |
| "Desipramine-induced increase in aggressive behavior was blocked by phentolamine (3 mg/kg, IP) and yohimbine (0." | 1.28 | Desipramine enhances isolation-induced aggressive behavior in mice. ( Cai, B; Matsumoto, K; Ohta, H; Satoh, T; Watanabe, H, 1991) |
| ", systemic subcutaneous administration and microinjection into the medial amygdala were employed to examine the effect of chronic administration of psychotropic drugs on muricide in olfactory bulbectomized rats." | 1.27 | Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats. ( Nakanishi, H; Shibata, S; Ueki, S; Watanabe, S, 1984) |
| " Chronic administration of desipramine also suppressed muricide and normalized noradrenaline changes in ventromedial and lateral hypothalamus and medial amygdala." | 1.27 | Changes in brain catecholamine levels following olfactory bulbectomy and the effect of acute and chronic administration of desipramine in rats. ( Fujiwara, M; Iwasaki, K; Shibata, S; Ueki, S, 1986) |
| "Rats were tested for changes in shock-elicited fighting (SEF) following the chronic administration of saline (IP); lithium (Li+) (20 mEq." | 1.26 | Effect of lithium upon desipramine enhanced shock-elicited fighting in rats. ( Prasad, V; Sheard, MH, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (74.42) | 18.7374 |
| 1990's | 7 (16.28) | 18.2507 |
| 2000's | 1 (2.33) | 29.6817 |
| 2010's | 2 (4.65) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Geyer, HM | 1 |
| Martin, LL | 1 |
| Crichlow, CA | 1 |
| Dekow, FW | 1 |
| Ellis, DB | 1 |
| Kruse, H | 1 |
| Setescak, LL | 1 |
| Worm, M | 1 |
| Khalifa, NR | 1 |
| Gibbon, S | 1 |
| Völlm, BA | 2 |
| Cheung, NH | 1 |
| McCarthy, L | 1 |
| Aoki, M | 1 |
| Watanabe, Y | 1 |
| Yoshimoto, K | 1 |
| Tsujimura, A | 1 |
| Yamamoto, T | 2 |
| Kanamura, N | 1 |
| Tanaka, M | 1 |
| Khalifa, N | 1 |
| Duggan, C | 1 |
| Stoffers, J | 1 |
| Huband, N | 1 |
| Ferriter, M | 1 |
| Lieb, K | 1 |
| Shibata, S | 4 |
| Watanabe, S | 2 |
| Liou, SY | 1 |
| Ueki, S | 5 |
| Nakanishi, H | 2 |
| Kostowski, W | 2 |
| Valzelli, L | 3 |
| Kozak, W | 1 |
| Bernasconi, S | 1 |
| Prasad, V | 3 |
| Sheard, MH | 3 |
| Eisenstein, N | 1 |
| Iorio, LC | 1 |
| Clody, DE | 1 |
| Willner, P | 1 |
| Theodorou, A | 1 |
| Montgomery, A | 1 |
| Matsumoto, K | 3 |
| Ojima, K | 2 |
| Watanabe, H | 3 |
| Ohta, H | 2 |
| Pellis, SM | 1 |
| Castañeda, E | 1 |
| McKenna, MM | 1 |
| Tran-Nguyen, LT | 1 |
| Whishaw, IQ | 1 |
| Tadano, T | 1 |
| Abe, Y | 1 |
| Morikawa, Y | 1 |
| Asao, T | 1 |
| Hozumi, M | 1 |
| Takahashi, N | 1 |
| Tan-no, K | 1 |
| Kisara, K | 1 |
| Matto, V | 1 |
| Skrebuhhova, T | 1 |
| Allikmets, L | 1 |
| Ferris, CF | 1 |
| Rasmussen, MF | 1 |
| Messenger, T | 1 |
| Koppel, G | 1 |
| Sheard, M | 1 |
| Astrachan, D | 1 |
| Davis, M | 1 |
| Peterson, GR | 1 |
| Blackwell, B | 1 |
| Hostetler, RM | 1 |
| Kuzma, R | 1 |
| Adolphe, A | 1 |
| Breese, GR | 1 |
| Cooper, BR | 1 |
| White, SM | 1 |
| Kucharik, RF | 1 |
| Moyer, JA | 1 |
| Cai, B | 1 |
| Satoh, T | 1 |
| van Praag, HM | 1 |
| Kahn, R | 1 |
| Asnis, GM | 1 |
| Lemus, CZ | 1 |
| Brown, SL | 1 |
| Hilakivi, LA | 1 |
| Durcan, MJ | 1 |
| Lister, RG | 1 |
| George, DT | 1 |
| Anderson, P | 1 |
| Nutt, DJ | 1 |
| Linnoila, M | 1 |
| Raleigh, MJ | 1 |
| Iwasaki, K | 1 |
| Fujiwara, M | 1 |
| Baiguerra, G | 1 |
| Donlon, PT | 1 |
| Blacker, KH | 1 |
| Baltzer, V | 1 |
| Bein, HJ | 1 |
| Zetler, G | 1 |
| Otten, U | 1 |
| Sofia, RD | 2 |
| Stern, P | 1 |
| Hadzović, J | 1 |
| Thoa, NB | 1 |
| Eichelman, B | 1 |
| Ng, LK | 1 |
| Yen, HC | 1 |
| Katz, MH | 1 |
| Krop, S | 1 |
| Kulkarni, AS | 1 |
| Schrold, J | 1 |
| Lapin, IP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Fluoxetine on Measures of Domestic Violence[NCT00011765] | Phase 2 | 104 participants (Actual) | Interventional | 2001-02-22 | Completed | ||
| Medication Development for Cocaine Dependence[NCT00249691] | Phase 3 | 180 participants (Anticipated) | Interventional | 2005-10-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for desipramine and Aggression
| Article | Year |
|---|---|
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2020 |
Pharmacological interventions for antisocial personality disorder.
Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; | 2010 |
41 other studies available for desipramine and Aggression
| Article | Year |
|---|---|
(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 1. Synthesis and evaluation of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and analogues as potential antidepressant agents.
Topics: Aggression; Animals; Antidepressive Agents; Benzodiazepines; Biogenic Amines; Chemical Phenomena; Ch | 1982 |
Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair.
Topics: Aggression; Animals; Antidepressive Agents, Tricyclic; Anxiety; Depression; Desipramine; Male; Mice; | 2016 |
Effects of adrenergic blockers on the inhibition of muricide by desipramine and noradrenaline injected into the amygdala in olfactory bulbectomized rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aggression; Amygdala; Animals; Biogenic A | 1983 |
Effects of adrenergic blockers on the inhibition of muricide by chronic administration of desipramine in oflactory bulbectomized rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aggression; Animals; Desipramine; Humans; | 1984 |
Activity of desipramine, fluoxetine and nomifensine on spontaneous and p-CPA-induced muricidal aggression.
Topics: Aggression; Animals; Antidepressive Agents; Desipramine; Fenclonine; Fluoxetine; Humans; Male; Nomif | 1984 |
Effect of lithium upon desipramine enhanced shock-elicited fighting in rats.
Topics: Aggression; Agonistic Behavior; Animals; Chlorides; Desipramine; Electroshock; Humans; Lithium; Lith | 1982 |
Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats.
Topics: Aggression; Amitriptyline; Amygdala; Animals; Antidepressive Agents; Chlorpromazine; Clomipramine; D | 1984 |
Time course of chronic desipramine on shock-elicited fighting in rats.
Topics: Aggression; Agonistic Behavior; Animals; Desipramine; Electroshock; Humans; Male; Rats; Rats, Inbred | 1983 |
Synergistic effect of propranolol and quipazine on desipramine enhanced shock-elicited fighting in rats.
Topics: Aggression; Animals; Desipramine; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Hu | 1983 |
Role of serotonin in the blockade of muricidal behavior by tricyclic antidepressants.
Topics: Aggression; Amitriptyline; Amphetamines; Animals; Desipramine; Diet; Humans; Imipramine; Male; Mice; | 1982 |
Subchronic treatment with the tricyclic antidepressant DMI increases isolation-induced fighting in rats.
Topics: Aggression; Agonistic Behavior; Animals; Body Weight; Desipramine; Dose-Response Relationship, Drug; | 1981 |
Noradrenergic denervation attenuates desipramine enhancement of aggressive behavior in isolated mice.
Topics: Aggression; Animals; Benzylamines; Brain; Denervation; Desipramine; Male; Mice; Mice, Inbred Strains | 1995 |
Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice.
Topics: Aggression; Animals; Clenbuterol; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; | 1994 |
The role of the striatum in organizing sequences of play fighting in neonatally dopamine-depleted rats.
Topics: Aggression; Animals; Animals, Newborn; Corpus Striatum; Desipramine; Dopamine; Female; Injections, I | 1993 |
Involvement of dopaminergic neurons in mouse-killing aggression in rats.
Topics: Aggression; Animals; Brain; Desipramine; Dopamine; Injections, Intraperitoneal; Male; Mice; Neurons; | 1997 |
The effect of antidepressants on rat aggressive behavior in the electric footshock and apomorphine-induced aggressiveness paradigms.
Topics: Aggression; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive | 1998 |
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder.
Topics: Adrenergic Uptake Inhibitors; Aggression; Animals; Arginine Vasopressin; Behavior, Animal; Clomipram | 2001 |
Effects of drugs on hyperactivity and aggression induced by raphe lesions in rats.
Topics: 5-Hydroxytryptophan; Aggression; Animals; Atropine; Brain Stem; Clomipramine; Desipramine; Humans; I | 1978 |
Tricyclic antidepressant drugs: antagonism of effect of D-lysergic acid diethylamide (LSD) on shock elicited aggression.
Topics: Aggression; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Desipramine; Electroshock; Huma | 1977 |
Anticholinergic activity of the tricyclic antidepressants desipramine and doxepin in nondepressed volunteers.
Topics: Adult; Aggression; Desipramine; Doxepin; Emotions; Female; Humans; Parasympatholytics; Placebos; Sal | 1978 |
Behavioral and biochemical interactions of 5,7-dihydroxytryptamine with various drugs when administered intracisternally to adult and developing rats.
Topics: 5,6-Dihydroxytryptamine; Aggression; Animals; Animals, Newborn; Avoidance Learning; Biogenic Amines; | 1975 |
Effects of serotonergic agents on isolation-induced aggression.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzamides; Benzodiazepines; Bridged Bicyclo Compounds; Br | 1991 |
Desipramine enhances isolation-induced aggressive behavior in mice.
Topics: Aggression; Animals; Clonidine; Desipramine; Imipramine; Male; Mice; Mice, Inbred Strains; Motor Act | 1991 |
Therapeutic indications for serotonin-potentiating compounds: a hypothesis.
Topics: 5-Hydroxytryptophan; Aggression; Antidepressive Agents; Anxiety; Brain; Depressive Disorder; Desipra | 1987 |
Effects of ethanol on fight- or swim-stressed mice in Porsolt's swim test.
Topics: Aggression; Animals; Desipramine; Ethanol; Male; Mice; Mice, Inbred Strains; Motor Activity; Referen | 1989 |
Aggressive thoughts and behavior: another symptom of panic disorder?
Topics: Adult; Aggression; Combined Modality Therapy; Desipramine; Fear; Female; Humans; Imipramine; Male; P | 1989 |
Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems.
Topics: 5-Hydroxytryptophan; Aggression; Animals; Arousal; Behavior, Animal; Brain; Chlorocebus aethiops; De | 1987 |
Changes in brain catecholamine levels following olfactory bulbectomy and the effect of acute and chronic administration of desipramine in rats.
Topics: Aggression; Amygdala; Animals; Brain Chemistry; Catecholamines; Desipramine; Dopamine; Hypothalamus; | 1986 |
Effect of chronic administration of alprazolam and adinazolam on clonidine- or apomorphine-induced aggression in laboratory rodents.
Topics: Aggression; Alprazolam; Animals; Anti-Anxiety Agents; Apomorphine; Benzodiazepines; Clonidine; Desip | 1986 |
Stages of schizophrenic decompensation and reintegration.
Topics: Adult; Affect; Aggression; Antipsychotic Agents; Anxiety; Depression; Desipramine; Fear; Female; Flu | 1973 |
Pharmacological investigations with benzoctamine (Tacitin), a new psycho-active agent.
Topics: Adjuvants, Anesthesia; Aggression; Animals; Anthracenes; Cats; Central Nervous System; Chlordiazepox | 1973 |
[Aggressiveness of the rat following combined treatment with monomaime oxidase inhibitors and other psychotropic drugs, especially thymoleptics].
Topics: Aggression; Alkaloids; Amitriptyline; Amphetamine; Animals; Anthracenes; Body Temperature; Central N | 1969 |
Structural relationship and potency of agents which selectively block mouse killing (muricide) behavior in rats.
Topics: Aggression; Animals; Antidepressive Agents; Behavior, Animal; Central Nervous System Stimulants; Chl | 1969 |
Pharmacological analysis of central actions of synthetic substance P.
Topics: Aggression; Animals; Blood-Brain Barrier; Desipramine; Humans; Male; Mice; Morphine; Strychnine; Sub | 1973 |
Shock-induced aggression: effects of 6-hydroxydopamine and other pharmacological agents.
Topics: Aggression; Amphetamine; Animals; Apomorphine; Brain; Catecholamines; Desipramine; Dihydroxyphenylal | 1972 |
Effects of some psychoactive drugs on conditioned avoidance response in aggressive mice.
Topics: Aggression; Animals; Antidepressive Agents; Avoidance Learning; Catecholamines; Conditioning, Psycho | 1971 |
Muricidal block produced by 5-hydroxytryptophan and various drugs.
Topics: 5-Hydroxytryptophan; Aggression; Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Desi | 1968 |
The exploratory behaviour in normal and aggressive mice.
Topics: Aggression; Amphetamine; Animals; Chlordiazepoxide; Chlorpromazine; Desipramine; Exploratory Behavio | 1969 |
Aggressive behaviour in chicks induced by tricyclic antidepressants.
Topics: Aggression; Animals; Behavior, Animal; Chickens; Desipramine; Dibenzazepines; Dibenzocycloheptenes; | 1970 |
Simple pharmacological procedures to differentiate antidepressants and cholinolytics in mice and rats.
Topics: Aggression; Animals; Antidepressive Agents; Atropine; Benactyzine; Desipramine; Exploratory Behavior | 1967 |
Effects of centrally active drugs on four models of experimentally-induced aggregession in rodents.
Topics: Acridines; Aggression; Animals; Antidepressive Agents; Azepines; Chlordiazepoxide; Desipramine; Diaz | 1969 |