desipramine has been researched along with Acute Post-Traumatic Stress Disorder in 13 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4." | 2.68 | REM latency, dexamethasone suppression test, and thyroid releasing hormone stimulation test in posttraumatic stress disorder. ( Chen, CC; Chicz-Demet, A; Demet, EM; Kauffmann, CD; Reist, C, 1995) |
| "The defining symptoms of PTSD include re-experiencing, avoidance and hyperarousal." | 1.40 | Methylphenidate and desipramine combined treatment improves PTSD symptomatology in a rat model. ( Aga-Mizrachi, S; Avital, A; Balan, A; Cymerblit-Sabba, A; Deshe, R; Gorodetsky, N; Grinstein, D; Gurman, O; Heinrich, N; Miller, L; Shwam, G; Tzezana, O; Zubedat, S, 2014) |
| "These findings support a link between PTSD and affective illness." | 1.27 | Biological markers of affective disorders and posttraumatic stress disorder: a pilot study with desipramine. ( Djenderedjian, A; Haier, RJ; Kauffman, CD; Nelson, JN; Reist, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aga-Mizrachi, S | 1 |
| Cymerblit-Sabba, A | 1 |
| Gurman, O | 1 |
| Balan, A | 1 |
| Shwam, G | 1 |
| Deshe, R | 1 |
| Miller, L | 1 |
| Gorodetsky, N | 1 |
| Heinrich, N | 1 |
| Tzezana, O | 1 |
| Zubedat, S | 1 |
| Grinstein, D | 1 |
| Avital, A | 1 |
| Davidson, J | 1 |
| Ipser, JC | 1 |
| Wilson, D | 1 |
| Akindipe, TO | 1 |
| Sager, C | 1 |
| Stein, DJ | 1 |
| Reist, C | 3 |
| Kauffmann, CD | 2 |
| Chicz-Demet, A | 2 |
| Chen, CC | 1 |
| Demet, EM | 2 |
| Yatham, LN | 2 |
| Sacamano, J | 1 |
| Kusumakar, V | 1 |
| Pohl, R | 1 |
| Balon, R | 1 |
| Lambert, MT | 1 |
| Dinan, TG | 1 |
| Barry, S | 1 |
| Mobayed, M | 1 |
| Brown, I | 1 |
| Frank, JB | 1 |
| Kosten, TR | 1 |
| Giller, EL | 1 |
| Haier, RJ | 2 |
| Sangdahl, C | 1 |
| Nelson, JN | 2 |
| Kudler, HS | 1 |
| Davidson, JR | 1 |
| Stein, R | 1 |
| Erickson, L | 1 |
| Kauffman, CD | 1 |
| Djenderedjian, A | 1 |
| Falcon, S | 1 |
| Ryan, C | 1 |
| Chamberlain, K | 1 |
| Curtis, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Relation Between Attentional, Sensory and Emotional Dysregulation in Adults With Posttraumatic Stress Disorder: a Double-blind, Placebo-controlled Randomized Controlled Trial of the Combined Treatment With Reboxetine and Methylphenidate[NCT05133804] | Phase 2 | 53 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for desipramine and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Pharmacotherapy for anxiety and comorbid alcohol use disorders.
Topics: Alcohol-Related Disorders; Anxiety; Anxiety Disorders; Buspirone; Comorbidity; Desipramine; Humans; | 2015 |
4 trials available for desipramine and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
REM latency, dexamethasone suppression test, and thyroid releasing hormone stimulation test in posttraumatic stress disorder.
Topics: Adult; Biomarkers; Depressive Disorder; Desipramine; Dexamethasone; Double-Blind Method; Humans; Hyd | 1995 |
A controlled trial of desipramine in 18 men with posttraumatic stress disorder.
Topics: Adult; Clinical Trials as Topic; Depression; Desipramine; Double-Blind Method; Humans; Male; Middle | 1989 |
Measuring results of treatment of PTSD.
Topics: Amitriptyline; Clinical Trials as Topic; Combat Disorders; Desipramine; Double-Blind Method; Humans; | 1989 |
Tricyclics: possible treatment for posttraumatic stress disorder.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Combat Disorders; | 1985 |
8 other studies available for desipramine and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Methylphenidate and desipramine combined treatment improves PTSD symptomatology in a rat model.
Topics: Animals; Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Desipramine; Disease M | 2014 |
Vintage treatments for PTSD: a reconsideration of tricyclic drugs.
Topics: Adrenergic Uptake Inhibitors; Alcoholism; Antidepressive Agents, Tricyclic; Desipramine; Diagnosis, | 2015 |
Assessment of noradrenergic functioning in patients with non-combat-related posttraumatic stress disorder: a study with desmethylimipramine and orthostatic challenges.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Arousal; Desipramine; Female; Human Growth Hormone; | 1996 |
Antidepressants, panic disorder, and PTSD.
Topics: Adult; Desipramine; Female; Fluoxetine; Humans; Panic Disorder; Stress Disorders, Post-Traumatic | 1992 |
Pheochromocytoma presenting as exacerbation of post traumatic stress disorder symptomology.
Topics: Adrenal Gland Neoplasms; Adult; Blood Pressure; Combat Disorders; Desipramine; Diagnostic Errors; Ho | 1992 |
A pilot study of a neuroendocrine test battery in posttraumatic stress disorder.
Topics: Adult; Buspirone; Desipramine; Dexamethasone; Female; Growth Hormone; Humans; Hydrocortisone; Middle | 1990 |
Antidepressants in the treatment of PTSD.
Topics: Depressive Disorder; Desipramine; Humans; Stress Disorders, Post-Traumatic | 1990 |
Biological markers of affective disorders and posttraumatic stress disorder: a pilot study with desipramine.
Topics: Adult; Depressive Disorder; Desipramine; Diagnosis, Differential; Humans; Male; Personality Inventor | 1987 |