desipramine has been researched along with Acute Pain in 2 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 10b was additionally bioavailable following oral dosing and demonstrated efficacy in rat models of acute, inflammatory, and neuropathic pain." | 1.37 | Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152). ( Adedoyin, A; Bray, JA; Deecher, DC; Fensome, A; Goldberg, JA; Harrison, J; Leventhal, L; Mann, C; Mark, L; Nogle, L; O'Neill, DJ; Spangler, TB; Sullivan, NR; Terefenko, EA; Trybulski, EJ; Uveges, AJ; Vu, A; Whiteside, GT; Zhang, P, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Neill, DJ | 1 |
| Adedoyin, A | 1 |
| Bray, JA | 1 |
| Deecher, DC | 1 |
| Fensome, A | 1 |
| Goldberg, JA | 1 |
| Harrison, J | 1 |
| Leventhal, L | 1 |
| Mann, C | 1 |
| Mark, L | 1 |
| Nogle, L | 1 |
| Sullivan, NR | 1 |
| Spangler, TB | 1 |
| Terefenko, EA | 1 |
| Trybulski, EJ | 1 |
| Uveges, AJ | 1 |
| Vu, A | 1 |
| Whiteside, GT | 1 |
| Zhang, P | 1 |
| Tochiki, KK | 1 |
| Maiarú, M | 1 |
| Norris, C | 1 |
| Hunt, SP | 1 |
| Géranton, SM | 1 |
2 other studies available for desipramine and Acute Pain
| Article | Year |
|---|---|
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
Topics: Acute Pain; Administration, Oral; Analgesics; Animals; Benzothiazoles; Biological Availability; Cell | 2011 |
The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour.
Topics: 5,6-Dihydroxytryptamine; Acute Pain; Adrenergic Uptake Inhibitors; Animals; Capsaicin; Desipramine; | 2016 |