desipramine has been researched along with Acute Brain Injuries in 14 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine content was also reduced in all examined brain regions." | 1.37 | Ontogenetic serotoninergic lesioning alters histaminergic activity in rats in adulthood. ( Boroń, D; Brus, H; Brus, R; Drab, J; Jochem, J; Jośko, J; Korossy-Mruk, E; Kostrzewa, RM; Nowak, P; Szkilnik, R, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lindgren, HS | 1 |
| Demirbugen, M | 1 |
| Bergqvist, F | 1 |
| Lane, EL | 1 |
| Dunnett, SB | 1 |
| Chang, CH | 1 |
| Chen, MC | 1 |
| Lu, J | 1 |
| Jośko, J | 1 |
| Drab, J | 1 |
| Jochem, J | 1 |
| Nowak, P | 1 |
| Szkilnik, R | 1 |
| Korossy-Mruk, E | 1 |
| Boroń, D | 1 |
| Kostrzewa, RM | 1 |
| Brus, H | 1 |
| Brus, R | 1 |
| BARRINGER, TJ | 1 |
| Raymond, JJ | 1 |
| Robertson, DM | 1 |
| Dinsdale, HB | 1 |
| Nag, S | 1 |
| Boyeson, MG | 1 |
| Harmon, RL | 1 |
| Reinhard, DL | 1 |
| Whyte, J | 1 |
| Sandel, ME | 1 |
| Molina, M | 1 |
| Díaz-Meza, JL | 1 |
| Saavedra, M | 1 |
| Ortiz, M | 1 |
| Contreras, CM | 1 |
| Wroblewski, BA | 1 |
| Joseph, AB | 1 |
| Cornblatt, RR | 1 |
| Dunn-Meynell, AA | 1 |
| Yarlagadda, Y | 1 |
| Levin, BE | 1 |
| Santos, AB | 1 |
| Ballenger, JC | 1 |
| Jackson, RD | 1 |
| Mysiw, WJ | 1 |
| Fogel, BS | 1 |
| Sparadeo, FR | 1 |
2 trials available for desipramine and Acute Brain Injuries
| Article | Year |
|---|---|
Antidepressant pharmacotherapy and the treatment of depression in patients with severe traumatic brain injury: a controlled, prospective study.
Topics: Accidents, Traffic; Adult; Brain Injuries; Cross-Over Studies; Depressive Disorder; Desipramine; Fem | 1996 |
Abnormal cortisol dynamics after traumatic brain injury. Lack of utility in predicting agitation or therapeutic response to tricyclic antidepressants.
Topics: Adolescent; Adult; Amitriptyline; Arousal; Brain Injuries; Clinical Trials as Topic; Desipramine; De | 1989 |
12 other studies available for desipramine and Acute Brain Injuries
| Article | Year |
|---|---|
The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain Injuries; Cell Count; Desipramine; Dopamine; Dopamine b | 2014 |
Effect of antidepressant drugs on the vmPFC-limbic circuitry.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain Injuries; Cell Count; Depression; Desipr | 2015 |
Ontogenetic serotoninergic lesioning alters histaminergic activity in rats in adulthood.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 5,7-Dihydroxytryptamine; Animals; Animal | 2011 |
CLINICAL TRIAL OF DESIPRAMINE IN THE TREATMENT OF DEPRESSION.
Topics: Brain; Brain Damage, Chronic; Brain Injuries; Depression; Depressive Disorder; Desipramine; Drug The | 1965 |
Pharmacological modification of blood-brain barrier permeability following a cold lesion.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Cerebrovascular Circulation; Cold Temperature; Desipra | 1984 |
Effects of trazodone and desipramine on motor recovery in brain-injured rats.
Topics: Analysis of Variance; Animals; Brain Injuries; Desipramine; Hemiplegia; Male; Psychomotor Performanc | 1993 |
Improved arousal and initiation following tricyclic antidepressant use in severe brain injury.
Topics: Activities of Daily Living; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arousal; Brain I | 1996 |
Raphe-septal neurons changes in sensitivity to desipramine following an early septal lesion in the rat.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain Injuries; Desipramine; Electric Stimulation; Electr | 1996 |
Alpha 1-adrenoceptor blockade increases behavioral deficits in traumatic brain injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; | 1997 |
Tricyclic antidepressant triggers mania in patient with organic affective disorder.
Topics: Adult; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain Injuries; Depressive Disorder; Desi | 1992 |
Focal cognitive deficits accentuated by depression.
Topics: Adult; Brain Diseases; Brain Injuries; Cognition Disorders; Depressive Disorder; Desipramine; Humans | 1985 |
Hypothalamic obesity and noradrenergic neural pathways.
Topics: Animals; Brain Injuries; Desipramine; Diet; Electrodes; Evaluation Studies as Topic; Feeding Behavio | 1974 |