desipramine has been researched along with Absence Seizure in 42 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study we performed parallel measurements of BDNF mRNA and protein expression in the frontal cortex and hippocampus of the rat after chronic treatment with electroconvulsive seizures (ECS), lithium, desipramine or escitalopram." | 7.72 | The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels. ( Jacobsen, JP; Mørk, A, 2004) |
| "5 mg/kg) significantly decreased latencies to generalized motor seizures induced 12 h later by the noncompetitive GABAA receptor antagonist picrotoxin (10 mg/kg)." | 7.68 | Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures. ( Borowski, TB; Kirkby, RD; Kokkinidis, L, 1993) |
| "In the present study we have investigated the effects of compounds which increase synaptic levels of noradrenaline on cocaine-induced seizures and lethality in mice." | 7.68 | Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality. ( Ball, DM; Jackson, HC; Nutt, DJ, 1990) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 5.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice." | 3.73 | Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics. ( Dohi, T; Kitayama, T; Morioka, N; Morita, K; Song, L, 2006) |
| "The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice." | 3.72 | Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. ( Arai, S; Dohi, T; Kihira, K; Kitayama, S; Kumagai, K; Kumagai, M; Morita, K, 2003) |
| " In the present study we performed parallel measurements of BDNF mRNA and protein expression in the frontal cortex and hippocampus of the rat after chronic treatment with electroconvulsive seizures (ECS), lithium, desipramine or escitalopram." | 3.72 | The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels. ( Jacobsen, JP; Mørk, A, 2004) |
| "5 mg/kg) significantly decreased latencies to generalized motor seizures induced 12 h later by the noncompetitive GABAA receptor antagonist picrotoxin (10 mg/kg)." | 3.68 | Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures. ( Borowski, TB; Kirkby, RD; Kokkinidis, L, 1993) |
| "In the present study we have investigated the effects of compounds which increase synaptic levels of noradrenaline on cocaine-induced seizures and lethality in mice." | 3.68 | Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality. ( Ball, DM; Jackson, HC; Nutt, DJ, 1990) |
| "The intracerebral microdialysis technique has been used to monitor extracellular levels of noradrenaline, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat hippocampus in vivo in response to focal and generalized seizures induced by hippocampal kindling stimulation." | 3.67 | Noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study. ( Bengzon, J; Kalén, P; Kokaia, M; Lindvall, O, 1989) |
| "Nisoxetine and desipramine (inhibitors of norepinephrine reuptake) each exerted a suppressant effect on spinal cord seizures by decreasing the duration of tonic extension." | 3.66 | Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats. ( Jobe, PC; Ray, TB, 1980) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 1.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "We investigated the effects of electroconvulsive seizure (ECS) on the expression of TSPs in the adult rat hippocampus." | 1.40 | Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus. ( Hisaoka-Nakashima, K; Kajitani, N; Morinobu, S; Okada-Tsuchioka, M; Segawa, M; Shibasaki, C; Takebayashi, M, 2014) |
| "Prazosin potentiated the anti-seizure effect of Ang III against MTW, GNCL, and THE in non-stressed mice while it reversed the seizure threshold-decreasing effect of this heptapeptide on MTW and GNCL in stressed mice." | 1.33 | Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism. ( Georgiev, V; Tchekalarova, J, 2006) |
| "Minimal electroshock seizure threshold (EST) was not significantly altered by L-DOPS at a dose of 200 or 400 mg/kg." | 1.28 | [Inhibitory effects of L-threo-DOPS on electroshock seizure in mice]. ( Nakanishi, T; Yoshida, M, 1989) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants." | 1.27 | Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex. ( Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI, 1988) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "However, the incidence of convulsions was increased by FLA-63 in rats pretreated with the catecholamine precursor L-dihydroxyphenylalanine." | 1.27 | Neuropharmacological modification of central catecholamines: effects on pinealectomy-induced convulsions. ( Blask, DE; Stockmeier, CA, 1986) |
| "The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats." | 1.27 | Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats. ( Peterson, SL; St Mary, JS; Trzeciakowski, JP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (71.43) | 18.7374 |
| 1990's | 4 (9.52) | 18.2507 |
| 2000's | 6 (14.29) | 29.6817 |
| 2010's | 2 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balsamo, A | 1 |
| Giorgi, I | 1 |
| Lapucci, A | 1 |
| Lucacchini, A | 1 |
| Macchia, B | 1 |
| Macchia, F | 1 |
| Martini, C | 1 |
| Rossi, A | 1 |
| Martin, LL | 1 |
| Worm, M | 1 |
| Agnew, MN | 1 |
| Kruse, H | 1 |
| Wilker, JC | 1 |
| Geyer, HM | 1 |
| Okada-Tsuchioka, M | 1 |
| Segawa, M | 1 |
| Kajitani, N | 1 |
| Hisaoka-Nakashima, K | 1 |
| Shibasaki, C | 1 |
| Morinobu, S | 1 |
| Takebayashi, M | 1 |
| Bittolo, T | 1 |
| Raminelli, CA | 1 |
| Deiana, C | 1 |
| Baj, G | 1 |
| Vaghi, V | 1 |
| Ferrazzo, S | 1 |
| Bernareggi, A | 1 |
| Tongiorgi, E | 1 |
| Pericić, D | 1 |
| Svob, D | 1 |
| Arai, S | 1 |
| Morita, K | 2 |
| Kitayama, S | 1 |
| Kumagai, K | 1 |
| Kumagai, M | 1 |
| Kihira, K | 1 |
| Dohi, T | 2 |
| KRAKOWSKI, AJ | 1 |
| LAMONT, ES | 1 |
| Jacobsen, JP | 1 |
| Mørk, A | 1 |
| Zorc, JJ | 1 |
| Ludwig, S | 1 |
| Kitayama, T | 1 |
| Song, L | 1 |
| Morioka, N | 1 |
| Tchekalarova, J | 1 |
| Georgiev, V | 1 |
| Gupta, ML | 1 |
| Gupta, TK | 1 |
| Bhargava, KP | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Sawyer, WT | 1 |
| Caudill, JL | 1 |
| Ellison, MJ | 1 |
| Jobe, PC | 3 |
| Ray, TB | 2 |
| McIntyre, DC | 1 |
| Edson, N | 1 |
| Chao, G | 1 |
| Knowles, V | 1 |
| Borowski, TB | 1 |
| Kirkby, RD | 1 |
| Kokkinidis, L | 1 |
| Cannizzaro, C | 1 |
| Cannizzaro, E | 1 |
| Gagliano, M | 1 |
| Mangiapane, N | 1 |
| Bourn, WM | 1 |
| Chin, L | 1 |
| Picchioni, AL | 1 |
| Geiger, PF | 1 |
| Woods, TW | 1 |
| Mims, ME | 1 |
| Lehmann, A | 1 |
| Reed, K | 1 |
| McKim, HR | 1 |
| Bymaster, FB | 1 |
| Perry, KW | 1 |
| Fuller, RW | 1 |
| Wong, DT | 1 |
| Kleinrok, Z | 1 |
| Gustaw, J | 1 |
| Czuczwar, SJ | 1 |
| Jackson, HC | 1 |
| Ball, DM | 1 |
| Nutt, DJ | 1 |
| Malatynska, E | 1 |
| Knapp, RJ | 1 |
| Ikeda, M | 1 |
| Yamamura, HI | 1 |
| Kokaia, M | 1 |
| Kalén, P | 1 |
| Bengzon, J | 1 |
| Lindvall, O | 1 |
| Yoshida, M | 1 |
| Nakanishi, T | 1 |
| Escorihuela, RM | 1 |
| Boix, F | 1 |
| Corda, MG | 1 |
| Tobeña, A | 1 |
| Fernández Teruel, A | 1 |
| Tribble, J | 1 |
| Weinhouse, E | 1 |
| Garland, J | 1 |
| Wendelberger, K | 1 |
| Dailey, JW | 1 |
| Stockmeier, CA | 2 |
| Larsen, BR | 1 |
| Blask, DE | 2 |
| Peterson, SL | 1 |
| Trzeciakowski, JP | 1 |
| St Mary, JS | 1 |
| Wallach, MB | 1 |
| Winters, WD | 1 |
| Mandell, AJ | 1 |
| Spooner, CE | 1 |
| Baltzer, V | 1 |
| Bein, HJ | 1 |
| Mennear, JH | 1 |
| Rudzik, AD | 1 |
| Brown, TC | 1 |
| Dwyer, ME | 1 |
| Stocks, JG | 1 |
| De Carolis, AS | 1 |
| Ziegler, H | 1 |
| Del Basso, P | 1 |
| Longo, VG | 1 |
| Schuckit, M | 1 |
| Robins, E | 1 |
| Feighner, J | 1 |
| Heitmann, R | 1 |
| Kunst, H | 1 |
42 other studies available for desipramine and Absence Seizure
| Article | Year |
|---|---|
3-[(2-ethoxyphenoxy)methyl]piperidine derivatives. Synthesis and antidepressant activity.
Topics: Animals; Antidepressive Agents; Blepharoptosis; Brain; Desipramine; Dopamine; Drug Evaluation, Precl | 1987 |
Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 6. Synthesis, 13C NMR, and biological evaluation of cis- and trans-4-amino-3'-arylspiro[cyclohexane-1,1'(3'H)-isobenzofuran] derivatives.
Topics: Animals; Antidepressive Agents; Benzofurans; Chemical Phenomena; Chemistry; Drug Synergism; Magnetic | 1981 |
Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus.
Topics: ADAM Proteins; ADAMTS1 Protein; Analysis of Variance; Animals; Antidepressive Agents; Desipramine; D | 2014 |
Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.
Topics: Animals; Antidepressive Agents; Atrophy; Breath Tests; Cerebral Cortex; Desipramine; GABAergic Neuro | 2016 |
Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Analysis of Variance; Animals | 2002 |
Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics.
Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Brain; Brain Chemistry; Citalopram; Cocai | 2003 |
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE: LONG-TERM TRIAL AND FOLLOW-UP.
Topics: Constipation; Depression; Depressive Disorder; Depressive Disorder, Major; Desipramine; Drug Hyperse | 1964 |
SIDE-EFFECTS OF PERTOFRAN.
Topics: Depression; Desipramine; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Seizures; Toxicology | 1965 |
The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Citalopram; Desipramine; Electroshock; Gene Expre | 2004 |
A 12-year-old girl with altered mental status and a seizure.
Topics: Child; Desipramine; Female; Humans; Mental Disorders; Seizures | 2004 |
Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.
Topics: Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Behavior, Animal; Brain Chemistry; Cocain | 2006 |
Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Angiotensin II; Angiotensin II Type 1 Re | 2006 |
Central anticholinergic activity of imipramine and allied drugs.
Topics: Amitriptyline; Animals; Atropine; Carbachol; Desipramine; Female; Imipramine; Male; Mice; Parasympat | 1967 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
A case of severe acute desipramine overdose.
Topics: Acute Disease; Adult; Bradycardia; Desipramine; Humans; Male; Respiratory Insufficiency; Seizures; S | 1984 |
Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats.
Topics: Animals; Benzofurans; Citalopram; Desipramine; Electric Stimulation; Female; Fluoxetine; Norepinephr | 1980 |
Differential effect of acute vs chronic desmethylimipramine on the rate of amygdala kindling in rats.
Topics: Amygdala; Animals; Desipramine; Dopamine; Kindling, Neurologic; Male; Norepinephrine; Rats; Rats, In | 1982 |
Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures.
Topics: Amphetamine; Animals; Antidepressive Agents; Bupropion; Desipramine; Male; Mice; N-Methylaspartate; | 1993 |
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists.
Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; | 1995 |
The role of dopamine in sound-induced convulsions.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Desipramine; Dopamine; Female; Hydroxydopamines; Rat | 1978 |
The relative significance of spinal cord norepinephrine and 5-hydroxytryptamine in electrically-induced seizure in the rat.
Topics: 5,7-Dihydroxytryptamine; Animals; Desipramine; Electric Stimulation; Female; Fenclonine; Hydroxydopa | 1978 |
Mechanisms underlying modifications in the severity of audiogenic convulsions.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Acoustic Sti | 1977 |
ECG changes in pure impramine overdose as function of plasma level.
Topics: Adult; Desipramine; Electrocardiography; Female; Heart; Heart Arrest; Heart Conduction System; Human | 1978 |
Nisoxetine prevents the 6-hydroxydopamine induced decrease in post-decapitation convulsions.
Topics: Animals; Brain Stem; Cerebral Cortex; Decerebrate State; Desipramine; Dose-Response Relationship, Dr | 1977 |
Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice.
Topics: Amitriptyline; Animals; Desipramine; Dose-Response Relationship, Drug; Electroshock; Imipramine; Mal | 1991 |
Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality.
Topics: Adrenergic alpha-Antagonists; Animals; Cocaine; Desipramine; Dioxanes; Hyperkinesis; Idazoxan; Injec | 1990 |
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chlorides; Desipramine; gamma-Aminob | 1988 |
Noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study.
Topics: Animals; Desipramine; Hippocampus; Hydroxydopamines; Hydroxyindoleacetic Acid; Kindling, Neurologic; | 1989 |
[Inhibitory effects of L-threo-DOPS on electroshock seizure in mice].
Topics: Animals; Anticonvulsants; Desipramine; Droxidopa; Drug Therapy, Combination; Electroshock; Male; Map | 1989 |
Chronic but not acute antidepressant treatment increases pentetrazol-induced convulsions in mice.
Topics: Animals; Antidepressive Agents; Desipramine; Drug Synergism; Imipramine; Male; Mice; Mice, Inbred St | 1989 |
Treatment of severe imipramine poisoning complicated by a negative history of drug ingestion.
Topics: Acute Disease; Desipramine; Electrocardiography; Emergencies; Female; Gastric Lavage; Humans; Imipra | 1989 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Alteration of seizures resulting from pinealectomy in the rat after neonatal treatment with 6-hydroxydopamine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Chemistry; Desipramine; Dopamine; Female; Hydroxy | 1985 |
Neuropharmacological modification of central catecholamines: effects on pinealectomy-induced convulsions.
Topics: alpha-Methyltyrosine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catechol | 1986 |
Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats.
Topics: Amoxapine; Animals; Antidepressive Agents; Clomipramine; Convulsants; Desipramine; Electric Stimulat | 1985 |
A correlation of EEG, reticular multiple unit activity and gross behavior following various antidepressant agents in the cat. IV.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Cats; Chlorpromazine; Desipramine; | 1969 |
Pharmacological investigations with benzoctamine (Tacitin), a new psycho-active agent.
Topics: Adjuvants, Anesthesia; Aggression; Animals; Anthracenes; Cats; Central Nervous System; Chlordiazepox | 1973 |
Potentiation of the anticonvulsant action of acetazolamide.
Topics: Acetazolamide; Amphetamine; Animals; Anticonvulsants; Caffeine; Cocaine; Desipramine; Drug Synergism | 1966 |
Antidepressant overdosage in children--a new menace.
Topics: Accidents, Home; Adolescent; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Child; Chil | 1971 |
Central effects of 6-hydroxydopamine.
Topics: Amantadine; Amitriptyline; Amphetamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Desiprami | 1971 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug | 1971 |
[Fatal poisoning with Pertofran].
Topics: Adult; Desipramine; Electrocardiography; Female; Humans; Seizures; Suicide | 1968 |