desipramine has been researched along with ANS (Autonomic Nervous System) Diseases in 5 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Somatic side effects of antidepressant medications and of depression and anxiety were quantified in depressed patients before and after 4 weeks of treatment with amitriptyline (N = 11), or desipramine (N = 12)." | 3.66 | Somatic symptoms in depression and antidepressants. ( Claghorn, JL; Mathew, RJ; Reck, JJ; Thapar, R; Weinman, ML, 1983) |
| "Desipramine treatment was associated with decreased 6-(18)F-fluorodopamine-derived radioactivity in the heart, renal cortex, and thyroid gland but not in the liver, spleen, renal pelvis, or salivary glands." | 2.71 | Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure. ( Goldstein, DS; Tipre, DN, 2005) |
| "All patients with PD and orthostatic hypotension had abnormal blood pressure responses to the Valsalva maneuver and septal and lateral ventricular myocardial concentrations of 6-[(18)F]fluorodopamine-derived radioactivity >2 SD below the normal mean." | 2.70 | Orthostatic hypotension from sympathetic denervation in Parkinson's disease. ( Bruce, SR; Dendi, R; Goldstein, DS; Holmes, CS; Li, ST, 2002) |
| "We have previously reported that murine AIDS produces a profound depletion of splenic norepinephrine (NE)." | 1.32 | Sympathetic nerve destruction in spleen in murine AIDS. ( Felten, DL; Grota, LJ; Kelley, SP; Moynihan, JA; Stevens, SY, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kelley, SP | 1 |
| Moynihan, JA | 1 |
| Stevens, SY | 1 |
| Grota, LJ | 1 |
| Felten, DL | 1 |
| Tipre, DN | 1 |
| Goldstein, DS | 2 |
| Mathew, RJ | 1 |
| Weinman, ML | 1 |
| Thapar, R | 1 |
| Reck, JJ | 1 |
| Claghorn, JL | 1 |
| Esler, M | 1 |
| Jackman, G | 1 |
| Leonard, P | 1 |
| Skews, H | 1 |
| Bobik, A | 1 |
| Korner, P | 1 |
| Holmes, CS | 1 |
| Dendi, R | 1 |
| Bruce, SR | 1 |
| Li, ST | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease[NCT01676103] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for desipramine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure.
Topics: Adult; Aged; Autonomic Nervous System; Autonomic Nervous System Diseases; Desipramine; Dopamine; Flu | 2005 |
Orthostatic hypotension from sympathetic denervation in Parkinson's disease.
Topics: Adrenergic Uptake Inhibitors; Aged; Autonomic Nervous System Diseases; Brain; Catecholamines; Desipr | 2002 |
3 other studies available for desipramine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Sympathetic nerve destruction in spleen in murine AIDS.
Topics: Adrenergic Uptake Inhibitors; Animals; Autonomic Nervous System Diseases; Desipramine; Disease Progr | 2003 |
Somatic symptoms in depression and antidepressants.
Topics: Adult; Amitriptyline; Anxiety; Autonomic Nervous System Diseases; Constipation; Depressive Disorder; | 1983 |
Effect of norepinephrine uptake blockers on norepinephrine kinetics.
Topics: Adult; Autonomic Nervous System Diseases; Desipramine; Humans; Male; Metabolic Clearance Rate; Neuro | 1981 |