desferrithiocin and Body-Weight

desferrithiocin has been researched along with Body-Weight* in 1 studies

Other Studies

1 other study(ies) available for desferrithiocin and Body-Weight

ArticleYear
An animal model of iron overload and its application to study hepatic ferritin iron mobilization by chelators.
    Biochemical pharmacology, 1986, Nov-01, Volume: 35, Issue:21

    Administration of 3,5,5-trimethylhexanoyl ferrocene in the diet of male Wistar rats results in a substantial increase in hepatic ferritin protein (greater than 2-fold) and of ferritin iron (4-8-fold). The iron-loading in liver, under the conditions used, appears to be essentially in parenchymal cells rather than in reticulo-endothelial cells. It is suggested that the model represents a useful system for the study of the potential efficacy of new iron chelators for the mobilization of hepatic storage iron. The ability of desferal (DFO) and of a new siderophore, desferrithiocin (DFT), to mobilize hepatic ferritin iron is observed in this model of iron overload. Desferrithiocin stimulates ferritin iron mobilization, when administered either by gavage or by intraperitoneal injection, whereas desferal is active intraperitoneally but inactive orally. Our studies lead to the conclusion that DFT merits further examinations, for its activity as an orally active iron chelator.

    Topics: Administration, Oral; Animals; Body Weight; Chelating Agents; Deferoxamine; Dihydropyridines; Ferritins; Ferrous Compounds; Injections, Intraperitoneal; Liver; Male; Metallocenes; Organ Size; Organometallic Compounds; Pyridines; Rats; Rats, Inbred Strains; Thiazoles

1986