desferrioxamine-b-succinyl-phenylalanine(1)-octreotide and Arthritis--Rheumatoid

We herein report a case of renal sarcoidosis presenting as acute kidney injury (AKI) during treatment with etanercept for rheumatoid arthritis. Blood tests showed a high level of angiotensin-converting enzyme and a renal biopsy demonstrated non-caseating granulomatous tubulointerstitial nephritis. The administration of high-dose steroid therapy (1 mg/kg) and discontinuation of etanercept resulted in an improvement in the patient's renal function. Although renal sarcoidosis induced by anti-tumor necrosis factor (TNF) therapy is an extremely rare manifestation, this case suggests that renal sarcoidosis should be considered in the differential diagnosis of AKI in patients receiving anti-TNF therapy, as providing an early diagnosis and treatment is important for preventing irreversible renal impairment.

Topics: Acute Kidney Injury; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Deferoxamine; Diagnosis, Differential; Etanercept; Female; Gallium Radioisotopes; Humans; Octreotide; Radionuclide Imaging; Sarcoidosis; Treatment Outcome; Tumor Necrosis Factor-alpha