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desethylamodiaquine and Malaria, Falciparum

desethylamodiaquine has been researched along with Malaria, Falciparum in 27 studies

*Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations. [MeSH]

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (44.44)29.6817
2010's12 (44.44)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
Bertaux, L; Bogreau, H; Bouchiba, H; Garnotel, E; Kraemer, P; Parzy, D; Pradines, B; Rogier, C; Savini, H; Simon, F1
Adjei, GO; Alifrangis, M; Goka, BQ; Hoegberg, LC; Kristensen, K; Kurtzhals, JA; Rodrigues, OP1
Greenhouse, B; Joloba, M; Kiggundu, M; Nanyunja, S; Nsobya, SL; Rosenthal, PJ1
Gut, J; Kumar, V; Raj, R; Rosenthal, PJ; Singh, P1
Arimondo, PB; Bon, C; Cadet-Daniel, V; Claes, A; Dobrescu, I; Erdmann, D; Halby, L; Hammam, E; Mairet-Khedim, M; Mecheri, S; Nardella, F; Peronet, R; Roesch, C; Scherf, A; Tafit, A; Viluma, J; Witkowski, B1
Bonkian, LN; d'Alessandro, U; Kazienga, A; Lingani, M; Mens, PF; Ouédraogo, JB; Ravinetto, R; Schallig, HDFH; Sorgho, H; Tinto, H; Valéa, I; Yerbanga, I1
Bazié, T; Dabiré, RK; Ehrlich, HY; Foy, BD; Goodwin, J; Lehane, A; Neya, C; Ouattara, JM; Ouédraogo, JB; Parikh, S; Somé, FA; Wade, M; Zachari, K1
Byaruhanga, O; Ceja, FG; Conrad, MD; Cooper, RA; Katairo, T; Nsobya, SL; Rasmussen, SA; Rosenthal, PJ; Tumwebaze, PK1
Anh, CX; Birrell, GW; Chavchich, M; Edstein, MD; Quang, NN; Rowcliffe, K; Travers, T; van Breda, K1
Cooksey, R; Dahlström, S; Fairhurst, RM; Flegg, JA; Guerin, PJ; Johnson, JD; Le Bras, J; Le Nagard, H; Lim, P; Ménard, D; Mentré, F; Murillo, C; Musset, L; Noedl, H; Nosten, F; Nsobya, SL; Pradines, B; Quashie, NB; Sibley, CH; Sinou, V; Sriprawat, K; Woodrow, CJ1
Baret, E; Bercion, R; Camara, C; Diatta, B; Diémé, Y; Fall, B; Fall, KB; Fall, M; Mbaye, PS; Nakoulima, A; Pascual, A; Pradines, B; Wade, B; Wurtz, N1
Amalvict, R; Camara, C; Diatta, B; Diémé, Y; Fall, B; Fall, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Joloba, M; Kiggundu, M; Nawaz, F; Nsobya, SL; Rosenthal, PJ1
Carn, G; Jullien, V; Juma, E; Kiechel, JR; Obonyo, C; Ogutu, B1
Adewoye, EO; Folarin, O; Gbotosho, GO; Happi, CT; Michael, OS; Okuboyejo, TM; Sijuade, AO; Sowunmi, A1
Assi, SB; Basco, LK; Bla, KB; Djaman, AJ; Koné, M; Mazabraud, A; Yavo, W1
Ali, A; Björkman, A; Ferreira, PE; Fröberg, G; Gil, JP; Mårtensson, A1
Basco, LK1
Aubouy, A; Bakary, M; Deloron, P; Keundjian, A; Le Bras, J; Mayombo, J1
Björkman, A; Ferreira, PM; Gil, JP; Holmgren, G; Obonyo, CO; Veiga, MI1
D'Alessandro, U; Erhart, A; Karema, C; Mupfasoni, D; Rusanganwa, E; Rwagacondo, C; Tinto, H; Van Marck, E; Van Overmeir, C; Vandoren, W1
Goldstein, JA; Kroetz, DL; Ouedraogo, JB; Parikh, S; Rosenthal, PJ1
Andrianantenaina, HB; Ariey, F; Domarle, O; Randrianarivelojosia, M; Rason, MA; Raveloson, A1
Ali, AS; Ashton, M; Bhattarai, A; Björkman, A; Hietala, SF; Hombhanje, FW; Kaneko, A; Msellem, M; Röshammar, D; Strömberg, J1
Arango, E; Cravo, P; Do Rosário, VE; Maestre, A; Restrepo-Pineda, E1
Basco, LK; Keundjian, A; Ringwald, P; Same Ekobo, A1

Trials

7 trial(s) available for desethylamodiaquine and Malaria, Falciparum

ArticleYear
Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:12

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Cytochrome P-450 CYP2C8; Drug Therapy, Combination; Female; Ghana; Humans; Malaria, Falciparum; Male; Polymorphism, Genetic; Treatment Outcome

2008
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Antimalarials; Child; Child, Preschool; Cohort Studies; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Treatment Outcome; Uganda

2010
In vivo/ex vivo efficacy of artemether-lumefantrine and artesunate-amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso.
    Malaria journal, 2020, Jan-06, Volume: 19, Issue:1

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Burkina Faso; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mass Drug Administration; Plasmodium falciparum; Treatment Failure; Treatment Outcome

2020
Changing Antimalarial Drug Sensitivities in Uganda.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:12

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethanolamines; Female; Fluorenes; Gene Expression; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines; Uganda; Young Adult

2017
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
    The Journal of infectious diseases, 2009, Dec-01, Volume: 200, Issue:11

    Topics: Amino Acid Sequence; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Preschool; Cohort Studies; Drug Combinations; Drug Resistance; Ethanolamines; Fluorenes; Humans; Infant; Malaria, Falciparum; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Pyrimethamine; Sequence Alignment; Sulfadoxine; Uganda

2009
Population pharmacokinetics and pharmacodynamic considerations of amodiaquine and desethylamodiaquine in Kenyan adults with uncomplicated malaria receiving artesunate-amodiaquine combination therapy.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Artemisinins; Drug Combinations; Female; Half-Life; Humans; Kenya; Malaria, Falciparum; Male; Middle Aged; Models, Biological; Treatment Outcome; Young Adult

2010
Therapeutic efficacy of artesunate-amodiaquine combinations and the plasma and saliva concentrations of desethylamodiaquine in children with acute uncomplicated Plasmodium falciparum malaria.
    American journal of therapeutics, 2013, Volume: 20, Issue:1

    Topics: Acute Disease; Administration, Oral; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Half-Life; Humans; Infant; Malaria, Falciparum; Male; Metabolic Clearance Rate; Saliva; Treatment Outcome

2013

Other Studies

20 other study(ies) available for desethylamodiaquine and Malaria, Falciparum

ArticleYear
First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Animals; Antimalarials; Atovaquone; Comoros; Drug Resistance; France; Genotype; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Travel; Treatment Failure

2008
Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation.
    European journal of medicinal chemistry, 2014, Volume: 71

    Topics: Antimalarials; beta-Lactams; Chloroquine; Humans; Malaria, Falciparum; Oxamic Acid; Plasmodium falciparum; Structure-Activity Relationship; Urea

2014
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
    Journal of medicinal chemistry, 2021, 07-22, Volume: 64, Issue:14

    Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Hydroxamic Acids; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Procainamide; Structure-Activity Relationship

2021
Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso.
    Malaria journal, 2020, Jul-06, Volume: 19, Issue:1

    Topics: Amodiaquine; Antimalarials; Burkina Faso; Chemoprevention; Child, Preschool; Cross-Sectional Studies; Cytochrome P-450 CYP2C8; Drug Resistance; Female; Genes, Protozoan; Humans; Infant; Malaria, Falciparum; Male; Plasma; Polymorphism, Genetic

2020
Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.
    The American journal of tropical medicine and hygiene, 2018, Volume: 99, Issue:1

    Topics: Amodiaquine; Antimalarials; Area Under Curve; Artemisinins; Biotransformation; Drug Administration Schedule; Drug Combinations; Half-Life; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Tablets; Young Adult

2018
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7

    Topics: Amodiaquine; Antimalarials; Artemisinins; Automation, Laboratory; Chloroquine; Drug Resistance; Drug Therapy, Combination; High-Throughput Screening Assays; Internet; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine

2013
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:12

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Biological Transport; Child; Chloroquine; Drug Resistance; Erythrocytes; Ethanolamines; Female; Fluorenes; Gene Expression; Haplotypes; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Quinine; Senegal

2014
Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014.
    Emerging infectious diseases, 2016, Volume: 22, Issue:5

    Topics: Amodiaquine; Antimalarials; Drug Resistance; Female; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Prevalence; Senegal

2016
Association between Polymorphisms in the Pf
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal

2017
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
    African health sciences, 2010, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Young Adult

2010
Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2

    Topics: Amodiaquine; Antimalarials; Biological Transport; Chloroquine; Drug Resistance; Genetic Fitness; Genotype; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Plasmodium falciparum

2013
Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 2003, Volume: 69, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Cameroon; Chloroquine; Culture Media; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Serum Albumin

2003
Short report: lack of prediction of amodiaquine efficacy in treating Plasmodium falciparum malaria by in vitro tests.
    The American journal of tropical medicine and hygiene, 2004, Volume: 71, Issue:3

    Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Drug Resistance; Gabon; Humans; In Vitro Techniques; Malaria, Falciparum; Parasitic Sensitivity Tests; Predictive Value of Tests; Treatment Outcome

2004
Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2006, Volume: 6, Issue:4

    Topics: Amino Acid Substitution; Amodiaquine; Animals; Antigens, Protozoan; Antimalarials; ATP-Binding Cassette Transporters; Child, Preschool; Drug Resistance; Humans; Infant; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins

2006
In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2006, Volume: 100, Issue:6

    Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance, Multiple; Female; Humans; Infant; Inhibitory Concentration 50; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Quinine; Rwanda; Sesquiterpenes

2006
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
    Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:2

    Topics: Alkynes; Amodiaquine; Antimalarials; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Burkina Faso; Chromatography, High Pressure Liquid; Cyclopropanes; Cytochrome P-450 CYP2C8; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Genotype; HIV Protease Inhibitors; Humans; Lopinavir; Malaria, Falciparum; Models, Biological; Polymorphism, Genetic; Pyridines; Pyrimidinones; Pyrones; Reverse Transcriptase Inhibitors; Saquinavir; Spectrophotometry, Ultraviolet; Sulfonamides; Treatment Outcome; Trimethoprim

2007
Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.
    The American journal of tropical medicine and hygiene, 2007, Volume: 76, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Humans; Inhibitory Concentration 50; Madagascar; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prevalence; Protozoan Proteins; Quinine; Rural Population

2007
Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria.
    Journal of pharmacokinetics and pharmacodynamics, 2007, Volume: 34, Issue:5

    Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Humans; Infant; Malaria, Falciparum; Models, Biological

2007
Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.
    Parasitology, 2008, Volume: 135, Issue:5

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Colombia; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Protozoan Proteins

2008
Chemoresistance of Plasmodium falciparum in the urban region of Yaounde, Cameroon. Part 2: Evaluation of the efficacy of amodiaquine and sulfadoxine-pyrimethamine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Yaounde, Came
    Tropical medicine & international health : TM & IH, 2000, Volume: 5, Issue:9

    Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Treatment Outcome; Urban Health

2000