desethylamodiaquine has been researched along with Malaria, Falciparum in 27 studies
*Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 12 (44.44) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Bertaux, L; Bogreau, H; Bouchiba, H; Garnotel, E; Kraemer, P; Parzy, D; Pradines, B; Rogier, C; Savini, H; Simon, F | 1 |
| Adjei, GO; Alifrangis, M; Goka, BQ; Hoegberg, LC; Kristensen, K; Kurtzhals, JA; Rodrigues, OP | 1 |
| Greenhouse, B; Joloba, M; Kiggundu, M; Nanyunja, S; Nsobya, SL; Rosenthal, PJ | 1 |
| Gut, J; Kumar, V; Raj, R; Rosenthal, PJ; Singh, P | 1 |
| Arimondo, PB; Bon, C; Cadet-Daniel, V; Claes, A; Dobrescu, I; Erdmann, D; Halby, L; Hammam, E; Mairet-Khedim, M; Mecheri, S; Nardella, F; Peronet, R; Roesch, C; Scherf, A; Tafit, A; Viluma, J; Witkowski, B | 1 |
| Bonkian, LN; d'Alessandro, U; Kazienga, A; Lingani, M; Mens, PF; Ouédraogo, JB; Ravinetto, R; Schallig, HDFH; Sorgho, H; Tinto, H; Valéa, I; Yerbanga, I | 1 |
| Bazié, T; Dabiré, RK; Ehrlich, HY; Foy, BD; Goodwin, J; Lehane, A; Neya, C; Ouattara, JM; Ouédraogo, JB; Parikh, S; Somé, FA; Wade, M; Zachari, K | 1 |
| Byaruhanga, O; Ceja, FG; Conrad, MD; Cooper, RA; Katairo, T; Nsobya, SL; Rasmussen, SA; Rosenthal, PJ; Tumwebaze, PK | 1 |
| Anh, CX; Birrell, GW; Chavchich, M; Edstein, MD; Quang, NN; Rowcliffe, K; Travers, T; van Breda, K | 1 |
| Cooksey, R; Dahlström, S; Fairhurst, RM; Flegg, JA; Guerin, PJ; Johnson, JD; Le Bras, J; Le Nagard, H; Lim, P; Ménard, D; Mentré, F; Murillo, C; Musset, L; Noedl, H; Nosten, F; Nsobya, SL; Pradines, B; Quashie, NB; Sibley, CH; Sinou, V; Sriprawat, K; Woodrow, CJ | 1 |
| Baret, E; Bercion, R; Camara, C; Diatta, B; Diémé, Y; Fall, B; Fall, KB; Fall, M; Mbaye, PS; Nakoulima, A; Pascual, A; Pradines, B; Wade, B; Wurtz, N | 1 |
| Amalvict, R; Camara, C; Diatta, B; Diémé, Y; Fall, B; Fall, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B | 1 |
| Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA | 1 |
| Joloba, M; Kiggundu, M; Nawaz, F; Nsobya, SL; Rosenthal, PJ | 1 |
| Carn, G; Jullien, V; Juma, E; Kiechel, JR; Obonyo, C; Ogutu, B | 1 |
| Adewoye, EO; Folarin, O; Gbotosho, GO; Happi, CT; Michael, OS; Okuboyejo, TM; Sijuade, AO; Sowunmi, A | 1 |
| Assi, SB; Basco, LK; Bla, KB; Djaman, AJ; Koné, M; Mazabraud, A; Yavo, W | 1 |
| Ali, A; Björkman, A; Ferreira, PE; Fröberg, G; Gil, JP; Mårtensson, A | 1 |
| Basco, LK | 1 |
| Aubouy, A; Bakary, M; Deloron, P; Keundjian, A; Le Bras, J; Mayombo, J | 1 |
| Björkman, A; Ferreira, PM; Gil, JP; Holmgren, G; Obonyo, CO; Veiga, MI | 1 |
| D'Alessandro, U; Erhart, A; Karema, C; Mupfasoni, D; Rusanganwa, E; Rwagacondo, C; Tinto, H; Van Marck, E; Van Overmeir, C; Vandoren, W | 1 |
| Goldstein, JA; Kroetz, DL; Ouedraogo, JB; Parikh, S; Rosenthal, PJ | 1 |
| Andrianantenaina, HB; Ariey, F; Domarle, O; Randrianarivelojosia, M; Rason, MA; Raveloson, A | 1 |
| Ali, AS; Ashton, M; Bhattarai, A; Björkman, A; Hietala, SF; Hombhanje, FW; Kaneko, A; Msellem, M; Röshammar, D; Strömberg, J | 1 |
| Arango, E; Cravo, P; Do Rosário, VE; Maestre, A; Restrepo-Pineda, E | 1 |
| Basco, LK; Keundjian, A; Ringwald, P; Same Ekobo, A | 1 |
7 trial(s) available for desethylamodiaquine and Malaria, Falciparum
| Article | Year |
|---|---|
Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; Cytochrome P-450 CYP2C8; Drug Therapy, Combination; Female; Ghana; Humans; Malaria, Falciparum; Male; Polymorphism, Genetic; Treatment Outcome | 2008 |
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
Topics: Antimalarials; Child; Child, Preschool; Cohort Studies; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Treatment Outcome; Uganda | 2010 |
In vivo/ex vivo efficacy of artemether-lumefantrine and artesunate-amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Burkina Faso; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mass Drug Administration; Plasmodium falciparum; Treatment Failure; Treatment Outcome | 2020 |
Changing Antimalarial Drug Sensitivities in Uganda.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Aspartic Acid Endopeptidases; Child; Child, Preschool; Chloroquine; Drug Resistance; Ethanolamines; Female; Fluorenes; Gene Expression; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinolines; Uganda; Young Adult | 2017 |
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
Topics: Amino Acid Sequence; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Preschool; Cohort Studies; Drug Combinations; Drug Resistance; Ethanolamines; Fluorenes; Humans; Infant; Malaria, Falciparum; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Pyrimethamine; Sequence Alignment; Sulfadoxine; Uganda | 2009 |
Population pharmacokinetics and pharmacodynamic considerations of amodiaquine and desethylamodiaquine in Kenyan adults with uncomplicated malaria receiving artesunate-amodiaquine combination therapy.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Artemisinins; Drug Combinations; Female; Half-Life; Humans; Kenya; Malaria, Falciparum; Male; Middle Aged; Models, Biological; Treatment Outcome; Young Adult | 2010 |
Therapeutic efficacy of artesunate-amodiaquine combinations and the plasma and saliva concentrations of desethylamodiaquine in children with acute uncomplicated Plasmodium falciparum malaria.
Topics: Acute Disease; Administration, Oral; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Half-Life; Humans; Infant; Malaria, Falciparum; Male; Metabolic Clearance Rate; Saliva; Treatment Outcome | 2013 |
20 other study(ies) available for desethylamodiaquine and Malaria, Falciparum
| Article | Year |
|---|---|
First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros.
Topics: Animals; Antimalarials; Atovaquone; Comoros; Drug Resistance; France; Genotype; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Travel; Treatment Failure | 2008 |
Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation.
Topics: Antimalarials; beta-Lactams; Chloroquine; Humans; Malaria, Falciparum; Oxamic Acid; Plasmodium falciparum; Structure-Activity Relationship; Urea | 2014 |
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Hydroxamic Acids; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Procainamide; Structure-Activity Relationship | 2021 |
Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso.
Topics: Amodiaquine; Antimalarials; Burkina Faso; Chemoprevention; Child, Preschool; Cross-Sectional Studies; Cytochrome P-450 CYP2C8; Drug Resistance; Female; Genes, Protozoan; Humans; Infant; Malaria, Falciparum; Male; Plasma; Polymorphism, Genetic | 2020 |
Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.
Topics: Amodiaquine; Antimalarials; Area Under Curve; Artemisinins; Biotransformation; Drug Administration Schedule; Drug Combinations; Half-Life; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Tablets; Young Adult | 2018 |
High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
Topics: Amodiaquine; Antimalarials; Artemisinins; Automation, Laboratory; Chloroquine; Drug Resistance; Drug Therapy, Combination; High-Throughput Screening Assays; Internet; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine | 2013 |
Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.
Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Biological Transport; Child; Chloroquine; Drug Resistance; Erythrocytes; Ethanolamines; Female; Fluorenes; Gene Expression; Haplotypes; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Male; Mefloquine; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Quinine; Senegal | 2014 |
Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014.
Topics: Amodiaquine; Antimalarials; Drug Resistance; Female; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Prevalence; Senegal | 2016 |
Association between Polymorphisms in the Pf
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal | 2017 |
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Young Adult | 2010 |
Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.
Topics: Amodiaquine; Antimalarials; Biological Transport; Chloroquine; Drug Resistance; Genetic Fitness; Genotype; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Mutation; Plasmodium falciparum | 2013 |
Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum.
Topics: Amodiaquine; Animals; Antimalarials; Cameroon; Chloroquine; Culture Media; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Serum Albumin | 2003 |
Short report: lack of prediction of amodiaquine efficacy in treating Plasmodium falciparum malaria by in vitro tests.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Drug Resistance; Gabon; Humans; In Vitro Techniques; Malaria, Falciparum; Parasitic Sensitivity Tests; Predictive Value of Tests; Treatment Outcome | 2004 |
Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.
Topics: Amino Acid Substitution; Amodiaquine; Animals; Antigens, Protozoan; Antimalarials; ATP-Binding Cassette Transporters; Child, Preschool; Drug Resistance; Humans; Infant; Malaria, Falciparum; Membrane Proteins; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins | 2006 |
In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.
Topics: Adolescent; Adult; Amodiaquine; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance, Multiple; Female; Humans; Infant; Inhibitory Concentration 50; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Quinine; Rwanda; Sesquiterpenes | 2006 |
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
Topics: Alkynes; Amodiaquine; Antimalarials; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Burkina Faso; Chromatography, High Pressure Liquid; Cyclopropanes; Cytochrome P-450 CYP2C8; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Genotype; HIV Protease Inhibitors; Humans; Lopinavir; Malaria, Falciparum; Models, Biological; Polymorphism, Genetic; Pyridines; Pyrimidinones; Pyrones; Reverse Transcriptase Inhibitors; Saquinavir; Spectrophotometry, Ultraviolet; Sulfonamides; Treatment Outcome; Trimethoprim | 2007 |
Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; DNA, Protozoan; Drug Resistance; Humans; Inhibitory Concentration 50; Madagascar; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prevalence; Protozoan Proteins; Quinine; Rural Population | 2007 |
Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Humans; Infant; Malaria, Falciparum; Models, Biological | 2007 |
Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Colombia; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Protozoan Proteins | 2008 |
Chemoresistance of Plasmodium falciparum in the urban region of Yaounde, Cameroon. Part 2: Evaluation of the efficacy of amodiaquine and sulfadoxine-pyrimethamine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Yaounde, Came
Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Treatment Outcome; Urban Health | 2000 |