Page last updated: 2024-10-25

dequalinium and Malaria

dequalinium has been researched along with Malaria in 2 studies

Dequalinium: A topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.
dequalinium : A quinolinium ion comprising decane in which one methyl hydrogen at each end of the molecule has been replaced by a 4-amino-2-methylquinolin-1-yl group.

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
" The orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 milligrams/kilogram) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity."1.37Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. ( Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y, 2011)
"Dequalinium was able to inhibit both processes in vitro with close correlation to a murine malaria model, reducing parasitemia levels, prolonging the survival time post-infection and curing 40% of infected mice using a combination therapy with a loading dose of chloroquine."1.34Plasmodium berghei: in vitro and in vivo activity of dequalinium. ( Gamboa de Domínguez, N; Rodrigues, JR, 2007)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Meister, S1
Plouffe, DM1
Kuhen, KL1
Bonamy, GM1
Wu, T1
Barnes, SW1
Bopp, SE1
Borboa, R1
Bright, AT1
Che, J1
Cohen, S1
Dharia, NV1
Gagaring, K1
Gettayacamin, M1
Gordon, P1
Groessl, T1
Kato, N1
Lee, MC1
McNamara, CW1
Fidock, DA1
Nagle, A1
Nam, TG1
Richmond, W1
Roland, J1
Rottmann, M1
Zhou, B1
Froissard, P1
Glynne, RJ1
Mazier, D1
Sattabongkot, J1
Schultz, PG1
Tuntland, T1
Walker, JR1
Zhou, Y1
Chatterjee, A1
Diagana, TT1
Winzeler, EA1
Rodrigues, JR1
Gamboa de Domínguez, N1

Other Studies

2 other studies available for dequalinium and Malaria

ArticleYear
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
    Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061

    Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resista

2011
Plasmodium berghei: in vitro and in vivo activity of dequalinium.
    Experimental parasitology, 2007, Volume: 115, Issue:1

    Topics: Animals; Anti-Infective Agents; Colorimetry; Dequalinium; Disease Models, Animal; Electrophoresis, P

2007