dequalinium has been researched along with Leukemia in 4 studies
Dequalinium: A topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.
dequalinium : A quinolinium ion comprising decane in which one methyl hydrogen at each end of the molecule has been replaced by a 4-amino-2-methylquinolin-1-yl group.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells." | 5.34 | Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production. ( Delgado, MD; Galeano, E; García-Pérez, AI; Nieto, E; Sancho, P, 2007) |
| "Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells." | 1.34 | Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production. ( Delgado, MD; Galeano, E; García-Pérez, AI; Nieto, E; Sancho, P, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| García-Pérez, AI | 3 |
| Galeano, E | 3 |
| Nieto, E | 3 |
| Estañ, MC | 1 |
| Sancho, P | 3 |
| Gurovic, MS | 1 |
| Lanza, AM | 1 |
| Adánez, Mdel C | 1 |
| Omaña, MC | 1 |
| Gómez, IG | 1 |
| Murray, AP | 1 |
| López, PS | 1 |
| Delgado, MD | 1 |
4 other studies available for dequalinium and Leukemia
| Article | Year |
|---|---|
Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways.
Topics: Apoptosis; Dequalinium; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Glutathione; Hu | 2014 |
Cytotoxic effects induced by combination of heliantriol B2 and dequalinium against human leukemic cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Dequalinium; Drug Therapy, Combinati | 2011 |
Dequalinium induces human leukemia cell death by affecting the redox balance.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Dequalinium; Drug Synergism; Glutathione; Humans; JN | 2011 |
Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Proliferation; | 2007 |