deoxyguanosine-triphosphate and Cell-Transformation--Neoplastic

deoxyguanosine-triphosphate has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for deoxyguanosine-triphosphate and Cell-Transformation--Neoplastic

Article	Year
Mechanisms of chemical mutagenesis and carcinogenesis: effects on DNA replication of methylation at the O6-guanine position of dGTP. Carcinogenesis, 1983, Volume: 4, Issue:12 The incorporation of O6-methyl-dGTP during DNA replication in vitro by 'Klenow' E. coli pol I was determined. O6-Methyl-dGTP was found to: (i) incorporate opposite T and C template residues, with a greater than 20-fold preference for T, and (ii) arrest DNA synthesis when incorporated in place of dATP at all but pyrimidine-rich growing-strand sequences. The significance of O6-methyl-dGTP incorporation during DNA biosynthesis in vivo for mutagenesis and carcinogenesis is discussed. Topics: Base Composition; Base Sequence; Cell Transformation, Neoplastic; Deoxyguanine Nucleotides; DNA Polymerase I; DNA Replication; Escherichia coli; Mutation; Plasmids; Templates, Genetic	1983

Article

Year

Mechanisms of chemical mutagenesis and carcinogenesis: effects on DNA replication of methylation at the O6-guanine position of dGTP.

Carcinogenesis, 1983, Volume: 4, Issue:12

The incorporation of O6-methyl-dGTP during DNA replication in vitro by 'Klenow' E. coli pol I was determined. O6-Methyl-dGTP was found to: (i) incorporate opposite T and C template residues, with a greater than 20-fold preference for T, and (ii) arrest DNA synthesis when incorporated in place of dATP at all but pyrimidine-rich growing-strand sequences. The significance of O6-methyl-dGTP incorporation during DNA biosynthesis in vivo for mutagenesis and carcinogenesis is discussed.

Topics: Base Composition; Base Sequence; Cell Transformation, Neoplastic; Deoxyguanine Nucleotides; DNA Polymerase I; DNA Replication; Escherichia coli; Mutation; Plasmids; Templates, Genetic

1983