deoxyelephantopin has been researched along with Neoplasms* in 3 studies
2 review(s) available for deoxyelephantopin and Neoplasms
| Article | Year |
|---|---|
Deoxyelephantopin and Its Isomer Isodeoxyelephantopin: Anti-Cancer Natural Products with Multiple Modes of Action.
Cancer is a leading cause of morbidity and mortality worldwide. The development of cancer involves aberrations in multiple pathways, representing promising targets for anti-cancer drug discovery. Natural products are regarded as a rich source for developing anti-cancer therapies due to their unique structures and favorable pharmacology and toxicology profiles. Deoxyelephantopin and isodeoxyelephantopin, sesquiterpene lactone compounds, are major components of Topics: Antineoplastic Agents; Apoptosis; Asteraceae; Biological Products; Humans; Lactones; Neoplasms; Sesquiterpenes | 2022 |
Deoxyelephantopin and Isodeoxyelephantopin as Potential Anticancer Agents with Effects on Multiple Signaling Pathways.
Cancer is the 2nd leading cause of death worldwide. The development of drugs to target only one specific signaling pathway has limited therapeutic success. Developing chemotherapeutics to target multiple signaling pathways has emerged as a new prototype for cancer treatment. Deoxyelephantopin (DET) and isodeoxyelephantopin (IDET) are sesquiterpene lactone components of " Topics: Animals; Antineoplastic Agents; Apoptosis; Asteraceae; Cell Line, Tumor; Cell Proliferation; Humans; Lactones; Neoplasms; Plant Extracts; Plants, Medicinal; Sesquiterpenes; Signal Transduction; Transcription Factors | 2017 |
1 other study(ies) available for deoxyelephantopin and Neoplasms
| Article | Year |
|---|---|
Divergent synthesis and identification of the cellular targets of deoxyelephantopins.
Herbal extracts containing sesquiterpene lactones have been extensively used in traditional medicine and are known to be rich in α,β-unsaturated functionalities that can covalently engage target proteins. Here we report synthetic methodologies to access analogues of deoxyelephantopin, a sesquiterpene lactone with anticancer properties. Using alkyne-tagged cellular probes and quantitative proteomics analysis, we identified several cellular targets of deoxyelephantopin. We further demonstrate that deoxyelephantopin antagonizes PPARγ activity in situ via covalent engagement of a cysteine residue in the zinc-finger motif of this nuclear receptor. Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cysteine; Humans; Lactones; Molecular Targeted Therapy; Neoplasms; PPAR gamma; Proteomics; Recombinant Proteins; Sesquiterpenes; Zinc Fingers | 2016 |