Compounds > deoxycytidine

deoxycytidine and Chronic Hepatitis C

deoxycytidine has been researched along with Chronic Hepatitis C in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.70)29.6817
2010's26 (96.30)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cotler, SJ; Dahari, H; Guedj, J; Layden, TJ; Nettles, RE; Perelson, AS; Rong, L; Sansone, ND; Uprichard, SL1
Harrison, SA; Torres, DM1
Baronas, V; Haines, K; Klumpp, K; Le Pogam, S; Li, L; Nájera, I; Piso, K; So, SS; Tong, X; Yan, JM1
Ackrill, A; Badman, E; Bernaards, C; Chan, A; Chen, YC; Kulkarni, R; Moreira, S; Smith, PF; Thommes, J; Zhu, Y1
Haines, K; Li, L; Najera, I; Tong, X1
Brennan, B; Canini, L; Chatterjee, A; Guedj, J; Lemenuel-Diot, A; Perelson, AS; Smith, PF1
Brunda, M; Chu, T; Elston, R; Gane, EJ; George, J; Glavini, K; Hammond, JM; Jensen, DM; Le Pogam, S; Nájera, I; Passe, S; Piekarska, A; Rodriguez, I; Zeuzem, S1
Canini, L; Chatterjee, A; Guedj, J; Lemenuel-Diot, A; Perelson, AS; Smith, PF1
Ahmadyar, S; Babusis, D; Barauskas, O; Feng, JY; McCutcheon, K; Park, Y; Perron, M; Perry, JK; Ray, AS; Sakowicz, R; Schultz, BE; Stepan, G; Xu, Y; Yu, H1
Forns, X; Hézode, C; Le Pogam, S; Lee, SS; Nájera, I; Scalori, A; Thommes, JA; Voulgari, A; Wedemeyer, H1
Barreiro, P; Collado, A; de Los Santos Gil, I; González-Serrano, M; Hernández-Burruezo, JJ; López-Cortés, LF; López-Ruz, MA; Macías, J; Martín-Rico, P; Merino, D; Mira, JA; Muñoz, L; Pineda, JA; Ríos-Villegas, MJ; Rivero, A; Soriano, V; Torres-Tortosa, M; Tural, C; Viciana, P1
Floridia, M; Manconi, PE; Ortu, F; Weimer, LE1
Berrey, M; Cammack, N; De La Rosa, A; Ewing, A; Kang, H; Kosaka, A; Le Pogam, S; Nájera, I; Seshaadri, A; Symonds, B; Yan, JM1
Thomas, DL1
Angus, PW; Baher, L; Berrey, MM; Bradford, W; Chu, T; Elston, R; Gane, EJ; Ipe, D; Laughlin, M; Lopatin, U; Morcos, PN; Najera, I; Ritchie, B; Roberts, SK; Shulman, NS; Smith, PF; Stedman, CA1
Ghany, MG; Seeff, LB1
Angus, PW; Chu, TW; Elston, R; Gane, EJ; Germer, S; Iglesias, VA; Ipe, D; Kulkarni, R; Lopatin, U; Lu, XY; Ritchie, B; Roberts, SK; Shulman, NS; Smith, PF; Stedman, C1
Jacobson, I; Najera, I; Pawlotsky, JM1
Gao, M; Lin, K; Liu, Q; Villareal, VA; Yang, PL1
Naggie, S; Sulkowski, MS1
Ali, S; Chhabra, M; Chin, DJ; Ilnicka, M; Kang, H; Klumpp, K; Kosaka, A; Le Pogam, S; Nájera, I; Shulman, NS; Smith, P; Yan, JM1
Gores, GJ; Razumilava, N1
Agbaji, O; Ekong, E; Graham, C; Hawkins, C; Idoko, J; Kanki, P; Meloni, S; Muazu, M; Murphy, R; Nimzing, L; Sankalé, JL; Thio, CL1
Cannizzaro, MV; Chimenti, S; Chiricozzi, A; Giunta, A; Nisticò, SP; Saraceno, R1
Bzowej, N; Chen, YC; Ferenci, P; Herring, R; Ipe, D; Jensen, D; Ma, MM; Munson, ML; Najera, I; Pockros, P; Rodriguez-Torres, M; Thommes, J; Vierling, J; Wedemeyer, H; Zeuzem, S1
Chen, YC; Cooper, C; Dickson, R; Jensen, D; Kulkarni, R; Lou Munson, M; Najera, I; Pockros, PJ; Ramji, A; Taylor, R; Thommes, J; Tice, A; Tsai, N; Vierling, JM1
Chen, WC; Hsu, YC; Lee, JC; Lin, CK; Lin, YT; Tseng, CK; Wu, YH1

Reviews

6 review(s) available for deoxycytidine and Chronic Hepatitis C

ArticleYear
Management of untreated and nonresponder patients with chronic hepatitis C.
    Seminars in liver disease, 2010, Volume: 30, Issue:4

    Topics: Alcohol Drinking; Antiviral Agents; Biopsy; Decision Making; Deoxycytidine; Disease Management; Disease Progression; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Liver; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Obesity; Polyethylene Glycols; Practice Patterns, Physicians'; Recombinant Proteins; Retreatment; Ribavirin; RNA, Viral; Treatment Failure; Viral Load; Virus Replication

2010
Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase.
    Antiviral therapy, 2012, Volume: 17, Issue:3

    Topics: Antiviral Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; RNA-Dependent RNA Polymerase; Treatment Outcome

2012
Anti-HCV drugs in the pipeline.
    Current opinion in virology, 2011, Volume: 1, Issue:6

    Topics: Animals; Antiviral Agents; Carbamates; Cyclosporine; Deoxycytidine; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Pyrrolidines; Valine; Virus Replication

2011
Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.
    Gastroenterology, 2012, Volume: 142, Issue:6

    Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Coinfection; Deoxycytidine; Dideoxynucleosides; Disease Progression; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Hepatitis C, Chronic; HIV Infections; Homosexuality, Male; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Diseases; Male; Oligopeptides; Organophosphonates; Polyethylene Glycols; Proline; Pyrrolidinones; Raltegravir Potassium; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Substance Abuse, Intravenous; Tenofovir; Treatment Outcome

2012
Classification, diagnosis, and management of cholangiocarcinoma.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013, Volume: 11, Issue:1

    Topics: Antineoplastic Agents; Cholangiocarcinoma; Cisplatin; Deoxycytidine; Drug Therapy; Gemcitabine; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Severity of Illness Index; Surgical Procedures, Operative

2013
Complete resolution of erythrodermic psoriasis in an HIV and HCV patient unresponsive to antipsoriatic treatments after highly active antiretroviral therapy (Ritonavir, Atazanavir, Emtricitabine, Tenofovir).
    Dermatology (Basel, Switzerland), 2012, Volume: 225, Issue:4

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Hepatitis C, Chronic; HIV Infections; Humans; Immunocompromised Host; Male; Middle Aged; Oligopeptides; Organophosphonates; Psoriasis; Pyridines; Ritonavir; Tenofovir; Treatment Outcome

2012

Trials

13 trial(s) available for deoxycytidine and Chronic Hepatitis C

ArticleYear
In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir.
    The Journal of infectious diseases, 2014, Mar-01, Volume: 209, Issue:5

    Topics: Antiviral Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Mutation; Polyethylene Glycols; Recombinant Proteins; Replicon; Ribavirin; RNA, Viral; Sofosbuvir; Uridine Monophosphate; Viral Nonstructural Proteins

2014
Identification of the NS5B S282T resistant variant and two novel amino acid substitutions that affect replication capacity in hepatitis C virus-infected patients treated with mericitabine and danoprevir.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6

    Topics: Adult; Amino Acid Substitution; Antiviral Agents; Base Sequence; Cyclopropanes; Deoxycytidine; DNA Replication; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Molecular Sequence Data; Mutation; Phenotype; Proline; RNA, Viral; Sequence Analysis, DNA; Sulfonamides; Viral Nonstructural Proteins

2014
A pharmacokinetic/viral kinetic model to evaluate the treatment effectiveness of danoprevir against chronic HCV.
    Antiviral therapy, 2015, Volume: 20, Issue:5

    Topics: Antiviral Agents; Cyclopropanes; Deoxycytidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Models, Theoretical; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; Sulfonamides; Treatment Outcome; Viral Load; Viral Nonstructural Proteins

2015
Interferon-free regimens containing setrobuvir for patients with genotype 1 chronic hepatitis C: a randomized, multicenter study.
    Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:4

    Topics: Adult; Antiviral Agents; Australia; Benzothiadiazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; New Zealand; Phenotype; Proline; Quinolones; Remission Induction; Ribavirin; RNA, Viral; Sulfonamides; Time Factors; Treatment Outcome; United States; Viral Load

2016
Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection.
    Antiviral therapy, 2016, Volume: 21, Issue:4

    Topics: Antiviral Agents; Cyclopropanes; Deoxycytidine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Models, Biological; Proline; RNA, Viral; Sulfonamides; Viral Load

2016
Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adult; Antibodies, Viral; Antimetabolites; Antiviral Agents; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome

2016
Efficacy of pegylated interferon plus ribavirin treatment in HIV/hepatitis C virus co-infected patients receiving abacavir plus lamivudine or tenofovir plus either lamivudine or emtricitabine as nucleoside analogue backbone.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 62, Issue:6

    Topics: Adenine; Adult; Anti-HIV Agents; Blood; Cohort Studies; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; Follow-Up Studies; Hepacivirus; Hepatitis C, Chronic; HIV Infections; HIV-1; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tenofovir; Treatment Outcome; Viral Load

2008
RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients.
    The Journal of infectious diseases, 2010, Nov-15, Volume: 202, Issue:10

    Topics: Amino Acid Substitution; Antiviral Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; New Zealand; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Selection, Genetic; United States; Viral Load; Viral Nonstructural Proteins; Virus Replication

2010
Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial.
    Lancet (London, England), 2010, Oct-30, Volume: 376, Issue:9751

    Topics: Administration, Oral; Adult; Antiviral Agents; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Isoindoles; Lactams; Lactams, Macrocyclic; Male; Middle Aged; Polyethylene Glycols; Proline; Recombinant Proteins; RNA, Viral; Sulfonamides; Viral Nonstructural Proteins

2010
Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C.
    Gastroenterology, 2012, Volume: 142, Issue:4

    Topics: Antiviral Agents; Australia; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Isoindoles; Kinetics; Lactams; Lactams, Macrocyclic; Models, Biological; Models, Statistical; New Zealand; Phenotype; Polymorphism, Single Nucleotide; Proline; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load; Virus Replication

2012
Characterization of hepatitis C virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11

    Topics: Adult; Antiviral Agents; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Enzyme Inhibitors; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Mutation; Placebos; Proline; RNA, Viral; Sulfonamides; Viral Load; Viral Nonstructural Proteins

2012
PROPEL: a randomized trial of mericitabine plus peginterferon alpha-2a/ribavirin therapy in treatment-naïve HCV genotype 1/4 patients.
    Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:2

    Topics: Adolescent; Adult; Aged; Deoxycytidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Male; Middle Aged; Polyethylene Glycols; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome; Young Adult

2013
JUMP-C: a randomized trial of mericitabine plus pegylated interferon alpha-2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients.
    Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:2

    Topics: Adolescent; Adult; Aged; Canada; Deoxycytidine; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Male; Middle Aged; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Treatment Outcome; United States; Young Adult

2013

Other Studies

8 other study(ies) available for deoxycytidine and Chronic Hepatitis C

ArticleYear
Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Mar-05, Volume: 110, Issue:10

    Topics: Adult; Antiviral Agents; Bayes Theorem; Carbamates; Cell Line; Deoxycytidine; Female; Half-Life; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Middle Aged; Models, Biological; Pyrrolidines; RNA, Viral; Valine; Viral Load; Viral Nonstructural Proteins; Virus Assembly

2013
Small steps toward a better treatment for chronic hepatitis C infection: mericitabine, pegylated interferon, and ribavirin in the PROPEL and JUMP-C trials.
    Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:2

    Topics: Deoxycytidine; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Polyethylene Glycols; Recombinant Proteins; Ribavirin

2013
Understanding the effect of the HCV polymerase inhibitor mericitabine on early viral kinetics in the phase 2 JUMP-C and PROPEL studies.
    British journal of clinical pharmacology, 2014, Volume: 78, Issue:3

    Topics: Adult; Aged; Antiviral Agents; Clinical Trials, Phase II as Topic; Deoxycytidine; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Male; Middle Aged; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Retrospective Studies; Ribavirin; Treatment Outcome; Young Adult

2014
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:2

    Topics: Antiviral Agents; Cell Line; Deoxycytidine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; Guanosine Monophosphate; Hepacivirus; Hepatitis C, Chronic; Humans; Mitochondria; Nucleosides; Oxygen Consumption; Protein Biosynthesis; RNA; RNA, Mitochondrial; Sofosbuvir; Transcription, Genetic; Virus Replication

2016
Raltegravir, tenofovir, and emtricitabine in an HIV-infected patient with HCV chronic hepatitis, NNRTI intolerance and protease inhibitors-induced severe liver toxicity.
    European journal of medical research, 2010, Feb-26, Volume: 15, Issue:2

    Topics: Adenine; Adult; Antiviral Agents; CD4-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis C, Chronic; HIV Infections; Humans; Liver; Lymphocyte Count; Organophosphonates; Protease Inhibitors; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Treatment Outcome; Viral Load

2010
Curing hepatitis C with pills: a step toward global control.
    Lancet (London, England), 2010, Oct-30, Volume: 376, Issue:9751

    Topics: Administration, Oral; Antiviral Agents; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Isoindoles; Lactams; Lactams, Macrocyclic; Proline; Sulfonamides; Viral Nonstructural Proteins

2010
Impact of hepatitis C virus on HIV response to antiretroviral therapy in Nigeria.
    Journal of acquired immune deficiency syndromes (1999), 2013, Feb-01, Volume: 62, Issue:2

    Topics: Adult; Alanine Transaminase; Alkynes; Anti-Retroviral Agents; Benzoxazines; Chemical and Drug Induced Liver Injury; Coinfection; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Lamivudine; Logistic Models; Male; Nevirapine; Nigeria; Organophosphorus Compounds; RNA, Viral; Stavudine; Zidovudine

2013
Green tea phenolic epicatechins inhibit hepatitis C virus replication via cycloxygenase-2 and attenuate virus-induced inflammation.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Antiviral Agents; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cyclooxygenase 2; Deoxycytidine; Gene Expression; Hepacivirus; Hepatitis C, Chronic; Humans; Inflammation; Interferon-alpha; Interleukin-1beta; Nitric Oxide Synthase Type II; Oligopeptides; RNA, Viral; Stereoisomerism; Tea; Tumor Necrosis Factor-alpha; Virus Replication

2013