deoxycytidine and Astrocytoma, Grade IV

deoxycytidine has been researched along with Astrocytoma, Grade IV in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.70)18.7374
1990's2 (5.41)18.2507
2000's11 (29.73)29.6817
2010's19 (51.35)24.3611
2020's4 (10.81)2.80

Authors

AuthorsStudies
Kavoosi, F; Sanaei, M1
Burgess, K; Jiang, Z; Kuai, D; Pflug, K; Sitcheran, R; Usama, SM; Yan, X1
Benoit, JP; Bronte, V; Della Puppa, A; Ingangi, V; Lollo, G; Magri, S; Mandruzzato, S; Marigo, I; Masetto, E; Matha, K; Pinton, L; Schibuola, I; Vettore, M1
Al-Youbi, AO; Bashammakh, AS; El-Shahawi, MS; Graham, RM; Leblanc, RM; Liyanage, PY; Vanni, S; Zhou, Y1
Courcelle, M; Djaker, N; Palama, T; Sahli, F; Savarin, P; Spadavecchia, J1
Bastiancich, C; Bastiat, G; Bianco, J; Danhier, F; Gallez, B; Joudiou, N; Lagarce, F; Préat, V; Ucakar, B; Vanvarenberg, K1
Maj, P; Nizioł, J; Rode, W; Ruman, T; Sobich, J; Uram, Ł1
Bastiancich, C; Bastiat, G; Lagarce, F1
Chen, T; Fu, Y; Gong, T; Huang, T; Li, W; Liu, X; Yang, Q; Zhang, Z1
Bastiancich, C; Bastiat, G; Bianco, J; Danhier, F; Franconi, F; Lagarce, F; Lemaire, L; Préat, V1
Bastiancich, C; Bastiat, G; Bozzato, E; Danhier, F; Luyten, U; Préat, V1
Altinoz, MA; Bilir, A; Elmaci, İ; Ozpinar, A1
Brons, S; Combs, SE; Debus, J; Haberer, T; Schlaich, F; Weber, KJ1
Bynoe, MS; Kim, DG1
Kim, JS; Lee, SJ; Ryu, JH; Shin, DH1
Bastiancich, C; Bastiat, G; Danhier, F; Lagarce, F; Pitorre, M; Préat, V; Ucakar, B; Vanvarenberg, K1
Bindra, R; Couvreur, P; Desmaële, D; Gaudin, A; King, AR; Saltzman, WM; Saucier-Sawyer, JK; Song, E1
Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ1
Carapella, CM; Carosi, M; Cognetti, F; Fabi, A; Giannarelli, D; Maschio, M; Metro, G; Mirri, MA; Pace, A; Pellegrini, D; Pompili, A; Russillo, M; Vidiri, A1
Cantor, A; Fathallah-Shaykh, HM; Fiveash, J; Grunda, JM; Johnson, MR; Nabors, LB; Palmer, CA1
Bekele, BN; Bobustuc, GC; Colman, H; Conrad, CA; Gilbert, MR; Groves, MD; Hsu, SH; Levin, VA; Puduvalli, VK; Qiao, W; Walbert, T; Yung, WK1
Brons, S; Combs, SE; Debus, J; Haberer, T; Habermehl, D; Rieken, S; Weber, KJ; Winter, M; Zipp, L1
Chenevert, TL; Galbán, CJ; Galbán, S; Heist, KA; Holland, EC; Johnson, TD; Lawrence, TS; Lemasson, B; Leopold, JS; Li, F; Mikkelsen, T; Rehemtulla, A; Ross, BD; Williams, TM1
Armesilla, AL; Bian, X; Brown, S; Channathodiyil, P; Darling, JL; Goktug, T; Guichet, PO; Hugnot, JP; Kannappan, V; Liu, P; Wang, W1
Bamberg, M; Dichgans, J; Duffner, F; Hermisson, M; Kortmann, RD; Küker, WM; Weller, M; Wick, W1
Bharara, S; Blanquicett, C; Buchsbaum, DJ; Diasio, RB; Gillespie, GY; Johnson, MR; Miller, CR; Nabors, LB1
Ostruszka, LJ; Shewach, DS2
Barten-van Rijbroek, A; Castro Kreder, N; Genç, M; Haveman, J; Stalpers, LJ1
Arcangeli, G; Carapella, CM; Carosi, MA; Cognetti, F; Fabi, A; Felici, A; Iandolo, B; Metro, G; Mirri, A; Occhipinti, E; Pace, A; Vidiri, A1
Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E1
Bitonti, AJ; Bush, TL; Piepmeier, JM; Prakash, NJ; Rabidou, N; Schold, SC1
Coucke, PA; Guillou, L; Li, YX; Sun, LQ1
Belanger, K; Forsyth, P; Fulton, D; Gertler, SZ; Goodyear, M; MacDonald, D; Perry, J; Seymour, L; Steward, W; Stewart, DJ; Wainman, N1
Bamberg, M; Dichgans, J; Heiss, E; Kortmann, RD; Küker, W; Meyermann, R; Streffer, J; Weller, M; Wick, W1
Aller, A; Alvarez, M; Arnold, D; Burk, R; Dauphinée, M; Greer, S; Knapinska, A; Mas, M; Norris, C; Wozniak, C1
Mundinger, F; Ostertag, C1

Reviews

1 review(s) available for deoxycytidine and Astrocytoma, Grade IV

ArticleYear
Gemcitabine and glioblastoma: challenges and current perspectives.
    Drug discovery today, 2018, Volume: 23, Issue:2

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Deoxycytidine; Gemcitabine; Glioblastoma; Humans; Nanomedicine; Radiation-Sensitizing Agents

2018

Trials

8 trial(s) available for deoxycytidine and Astrocytoma, Grade IV

ArticleYear
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biological Availability; Biopsy; Brain Neoplasms; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Female; Floxuridine; Gemcitabine; Glioblastoma; Humans; Male; Middle Aged; Nucleoside Deaminases; Radiation-Sensitizing Agents

2009
Phase II study of fixed dose rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma multiforme.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Deoxycytidine; DNA Modification Methylases; DNA Repair Enzymes; Female; Gemcitabine; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Radiation-Sensitizing Agents; Tumor Suppressor Proteins

2010
Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, May-15, Volume: 16, Issue:10

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Capecitabine; Combined Modality Therapy; Deoxycytidine; Drug Resistance, Neoplasm; Female; Fluorouracil; Gene Expression Profiling; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Pharmacogenetics; Proportional Hazards Models; Radiotherapy; Young Adult

2010
Neoadjuvant gemcitabine/treosulfan chemotherapy for newly diagnosed glioblastoma: a phase II study.
    Journal of neuro-oncology, 2002, Volume: 59, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Brain Neoplasms; Busulfan; Deoxycytidine; Disease-Free Survival; Drug Therapy, Combination; Female; Gemcitabine; Glioblastoma; Hematologic Diseases; Humans; Male; Middle Aged; Neoadjuvant Therapy; Venous Thrombosis

2002
Fixed dose-rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma: a dose-finding study.
    Journal of neuro-oncology, 2008, Volume: 87, Issue:1

    Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Deoxycytidine; Female; Gemcitabine; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Middle Aged; Radiation-Sensitizing Agents; Survival Analysis; Survival Rate

2008
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
    Oncology, 2007, Volume: 73, Issue:1-2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabine; Cyclooxygenase 2 Inhibitors; Dacarbazine; Deoxycytidine; Drug Administration Schedule; Edema; Efferent Pathways; Erythema; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Immunohistochemistry; Lactones; Male; Middle Aged; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Pioglitazone; PPAR gamma; Predictive Value of Tests; Quality of Life; Sulfones; Temozolomide; Thiazolidinediones; Treatment Outcome

2007
NCIC-CTG phase II study of gemcitabine in patients with malignant glioma (IND.94).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Deoxycytidine; Female; Gemcitabine; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Steroids

2000
Preirradiation gemcitabine chemotherapy for newly diagnosed glioblastoma. A phase II study.
    Cancer, 2001, Jan-15, Volume: 91, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Deoxycytidine; Female; Gemcitabine; Glioblastoma; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Prospective Studies; Radiation-Sensitizing Agents; Radiotherapy Dosage; Thrombocytopenia

2001

Other Studies

28 other study(ies) available for deoxycytidine and Astrocytoma, Grade IV

ArticleYear
The Effect of 5-aza,2'-deoxyCytidine (5 AZA CdR or Decitabine) on Extrinsic, Intrinsic, and JAK/STAT Pathways in Neuroblastoma and Glioblastoma Cells Lines.
    Asian Pacific journal of cancer prevention : APJCP, 2023, Jun-01, Volume: 24, Issue:6

    Topics: Azacitidine; Cell Line; Cell Line, Tumor; Decitabine; Deoxycytidine; DNA Methylation; Glioblastoma; Humans; Janus Kinases; Neuroblastoma; Signal Transduction; STAT Transcription Factors

2023
Cyanine-Gemcitabine Conjugates as Targeted Theranostic Agents for Glioblastoma Tumor Cells.
    Journal of medicinal chemistry, 2019, 10-24, Volume: 62, Issue:20

    Topics: Animals; Antineoplastic Agents; Carbocyanines; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Stability; Female; Gemcitabine; Glioblastoma; Humans; Mice; Mice, Nude; Theranostic Nanomedicine; Tissue Distribution; Transplantation, Heterologous

2019
Targeting of immunosuppressive myeloid cells from glioblastoma patients by modulation of size and surface charge of lipid nanocapsules.
    Journal of nanobiotechnology, 2020, Feb-17, Volume: 18, Issue:1

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Membrane Permeability; Deoxycytidine; Drug Compounding; Endocytosis; Gemcitabine; Glioblastoma; Humans; Immunosuppressive Agents; Immunotherapy; Leukocytes; Lipids; Macrophages; Myeloid-Derived Suppressor Cells; Nanocapsules; Particle Size; Signal Transduction; Surface Properties

2020
Pediatric glioblastoma target-specific efficient delivery of gemcitabine across the blood-brain barrier via carbon nitride dots.
    Nanoscale, 2020, Apr-14, Volume: 12, Issue:14

    Topics: Animals; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Cell Line; Cell Survival; Deoxycytidine; Drug Carriers; Gemcitabine; Glioblastoma; Humans; Larva; Nitriles; Quantum Dots; Transferrin; Zebrafish

2020
Temozolomide, Gemcitabine, and Decitabine Hybrid Nanoconjugates: From Design to Proof-of-Concept (PoC) of Synergies toward the Understanding of Drug Impact on Human Glioblastoma Cells.
    Journal of medicinal chemistry, 2020, 07-09, Volume: 63, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Decitabine; Deoxycytidine; Drug Delivery Systems; Drug Liberation; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Glioblastoma; Gold; Humans; Magnetic Resonance Spectroscopy; Metal Nanoparticles; Nanoconjugates; Proof of Concept Study; Spectrophotometry, Ultraviolet; Temozolomide

2020
Injectable nanomedicine hydrogel for local chemotherapy of glioblastoma after surgical resection.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, Oct-28, Volume: 264

    Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Deoxycytidine; Female; Gemcitabine; Glioblastoma; Humans; Hydrogels; Injections; Lipids; Mice; Nanocapsules; Nanomedicine; Xenograft Model Antitumor Assays

2017
N(4)-[B-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan)methyl]-2'-deoxycytidine as a potential boron delivery agent with respect to glioblastoma.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 95

    Topics: Animals; Apoptosis; Boron; Boron Compounds; Brain Neoplasms; Caenorhabditis elegans; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Shape; Deoxycytidine; DNA; Glioblastoma; Mass Spectrometry; Models, Animal; Substrate Specificity

2017
Hyaluronic Acid-Modified Micelles Encapsulating Gem-C
    Molecular pharmaceutics, 2018, 03-05, Volume: 15, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Deoxycytidine; Drug Carriers; Drug Compounding; Gemcitabine; Glioblastoma; Humans; Hyaluronan Receptors; Hyaluronic Acid; Lignans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Rats; Rats, Sprague-Dawley; Spheroids, Cellular; Survival Rate; Treatment Outcome; Xenograft Model Antitumor Assays

2018
Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models.
    Nanomedicine (London, England), 2018, Volume: 13, Issue:16

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Deoxycytidine; Female; Gemcitabine; Glioblastoma; Hydrogels; Magnetic Resonance Imaging; Nanomedicine; Rats; Rats, Sprague-Dawley

2018
Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment.
    International journal of pharmaceutics, 2019, Mar-25, Volume: 559

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Deoxycytidine; Drug Carriers; Drug Combinations; Drug Liberation; Gemcitabine; Glioblastoma; Hydrogels; Injections; Lipids; Mice; Nanocapsules; Nanomedicine; Paclitaxel; Rats

2019
Gemcitabine, vinorelbine and cyclooxygenase inhibitors in the treatment of glioblastoma. Ultrastructural analyses in C6 glioma in vitro.
    Tissue & cell, 2019, Volume: 59

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagic Cell Death; Cyclooxygenase Inhibitors; Deoxycytidine; Gemcitabine; Glioblastoma; Humans; Vinorelbine

2019
Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro.
    Radiation oncology (London, England), 2013, Nov-06, Volume: 8

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Carbon; Cell Cycle; Cell Line, Tumor; Cell Separation; Chemoradiotherapy; Cisplatin; Colonic Neoplasms; Deoxycytidine; Dose-Response Relationship, Radiation; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Glioblastoma; Humans; Ions; Lung Neoplasms; Paclitaxel; Pancreatic Neoplasms; Photons; Propidium; Radiotherapy; Relative Biological Effectiveness; Time Factors

2013
A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability.
    Molecular neurobiology, 2015, Volume: 52, Issue:1

    Topics: Adenosine A2 Receptor Agonists; Adherens Junctions; Animals; Antineoplastic Agents; Blood-Brain Barrier; Cell Death; Cell Line; Cell Membrane Permeability; Cell Movement; Deoxycytidine; Down-Regulation; Electric Impedance; Endothelial Cells; Focal Adhesions; Gemcitabine; Glioblastoma; Humans; Jurkat Cells; Mice, Inbred C57BL; Phosphorylation; Receptors, Adenosine A2; rhoA GTP-Binding Protein; Signal Transduction; Stress Fibers; T-Lymphocytes; Tight Junctions

2015
Synergistic Effect of Immunoliposomal Gemcitabine and Bevacizumab in Glioblastoma Stem Cell-Targeted Therapy.
    Journal of biomedical nanotechnology, 2015, Volume: 11, Issue:11

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Bevacizumab; Deoxycytidine; Drug Delivery Systems; Drug Synergism; Gemcitabine; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Liposomes; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Xenograft Model Antitumor Assays

2015
Lauroyl-gemcitabine-loaded lipid nanocapsule hydrogel for the treatment of glioblastoma.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, Mar-10, Volume: 225

    Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Deoxycytidine; Drug Liberation; Female; Gemcitabine; Glioblastoma; Humans; Hydrogels; Injections; Lipids; Mice, Nude; Nanocapsules; Needles; Rheology; Tumor Burden

2016
PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma.
    Biomaterials, 2016, Volume: 105

    Topics: Absorption, Physicochemical; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Deoxycytidine; Diffusion; Dose-Response Relationship, Drug; Gemcitabine; Glioblastoma; Humans; Molecular Imaging; Nanocapsules; Polyethylene Glycols; Rats; Squalene; Treatment Outcome

2016
Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma.
    Journal of neuro-oncology, 2011, Volume: 102, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Capecitabine; Celecoxib; Dacarbazine; Deoxycytidine; Female; Fluorouracil; Glioblastoma; Gliosarcoma; Humans; Lomustine; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Pyrazoles; Sulfonamides; Survival Rate; Temozolomide; Thioguanine; Treatment Outcome; Young Adult

2011
In vitro evaluation of photon and carbon ion radiotherapy in combination with chemotherapy in glioblastoma cells.
    Radiation oncology (London, England), 2012, Jan-27, Volume: 7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carbon; Cell Line, Tumor; Chemoradiotherapy; Cisplatin; Deoxycytidine; Dose-Response Relationship, Radiation; Gemcitabine; Glioblastoma; Humans; In Vitro Techniques; Paclitaxel; Photons; Tumor Stem Cell Assay

2012
DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Cell Line; Chemoradiotherapy; Dacarbazine; Deoxycytidine; Diffusion Magnetic Resonance Imaging; Drug Screening Assays, Antitumor; Gemcitabine; Glioblastoma; Humans; Kaplan-Meier Estimate; Mice; Mice, Transgenic; Neoplasms, Experimental; Radiation-Sensitizing Agents; Temozolomide; Treatment Outcome; Tumor Burden

2012
Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells.
    British journal of cancer, 2012, Oct-23, Volume: 107, Issue:9

    Topics: Aldehyde Dehydrogenase; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Copper; Cytotoxicity, Immunologic; Deoxycytidine; Disulfiram; Drug Synergism; Gemcitabine; Glioblastoma; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Neoplastic Stem Cells; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species

2012
Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:12

    Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Capecitabine; Combined Modality Therapy; Cytokines; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Glioblastoma; Humans; Interferon-gamma; Liver; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Oxidoreductases; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thymidine Phosphorylase; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2002
The role of DNA synthesis inhibition in the cytotoxicity of 2',2'-difluoro-2'-deoxycytidine.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:4

    Topics: Antineoplastic Agents; Aphidicolin; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Deoxycytidine; DNA, Neoplasm; Enzyme Inhibitors; Gemcitabine; Glioblastoma; Humans; Hydroxyurea; Nucleic Acid Synthesis Inhibitors; Pyrimidine Nucleosides; Ribonucleotide Reductases

2003
Enhancement of effects of irradiation by gemcitabine in a glioblastoma cell line and cell line spheroids.
    Journal of cancer research and clinical oncology, 2004, Volume: 130, Issue:1

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Gemcitabine; Glioblastoma; Humans; Radiation-Sensitizing Agents; Spheroids, Cellular

2004
In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor.
    Cancer research, 1996, Jan-15, Volume: 56, Issue:2

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Deoxycytidine; Enzyme Inhibitors; Glioblastoma; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Ribonucleoside Diphosphate Reductase; Transplantation, Heterologous

1996
(E)-2'-deoxy-2'-(fluoromethylene) cytidine potentiates radioresponse of two human solid tumor xenografts.
    Cancer research, 1998, Dec-01, Volume: 58, Issue:23

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Combined Modality Therapy; Deoxycytidine; Female; Glioblastoma; Humans; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms

1998
The role of cell cycle progression in radiosensitization by 2',2'-difluoro-2'-deoxycytidine.
    Cancer research, 2000, Nov-01, Volume: 60, Issue:21

    Topics: Adenosine Triphosphate; Apoptosis; Bromodeoxyuridine; Cell Cycle; Deoxyadenine Nucleotides; Deoxycytidine; Gemcitabine; Glioblastoma; Humans; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2000
Five-chlorodeoxycytidine, a tumor-selective enzyme-driven radiosensitizer, effectively controls five advanced human tumors in nude mice.
    International journal of radiation oncology, biology, physics, 2001, Nov-01, Volume: 51, Issue:3

    Topics: Animals; Breast Neoplasms; Carcinoma, Squamous Cell; Combined Modality Therapy; DCMP Deaminase; Deoxycytidine; Deoxycytidine Kinase; Female; Glioblastoma; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms; Prostatic Neoplasms; Radiation-Sensitizing Agents; Radiotherapy Dosage; Spinal Cord; Tetrahydrouridine

2001
Post-operative stereotactic Curie-therapy using the iridium-192 GammaMed contact irradiation apparatus combined with radio-sensitizers in treating multiform glioblastomas.
    Acta neurochirurgica, 1978, Volume: 42, Issue:1-2

    Topics: Brain Neoplasms; Bromodeoxycytidine; Bromodeoxyuridine; Deoxycytidine; Glioblastoma; Humans; Iridium; Postoperative Period; Radiation-Sensitizing Agents; Radioisotopes; Radiotherapy; Radiotherapy Dosage; Stereotaxic Techniques

1978