deoxycholic-acid and Toxemia

Forty patients with obstructive jaundice (bilirubin greater than 100 mumol/l) were entered into a randomized trial of oral ursodeoxycholic acid for 48 h before surgery versus no additional therapy. Pre-operative venous and operative portal total bile salt concentrations were higher in the bile salt treated patients (P less than 0.001). Portal endotoxaemia during operation was reduced in ursodeoxycholic acid treated patients (P less than 0.05). There was no significant difference in systemic venous endotoxaemia, renal function or postoperative morbidity or mortality. This study suggests pre-operative oral bile salt therapy may be of no clinical benefit in patients with obstructive jaundice.

Topics: Administration, Oral; Adolescent; Adult; Aged; Cholestasis; Clinical Trials as Topic; Creatinine; Deoxycholic Acid; Endotoxins; Female; Humans; Intraoperative Complications; Male; Middle Aged; Premedication; Random Allocation; Toxemia; Ursodeoxycholic Acid