deoxycholic-acid and Stomach-Ulcer

Topics: Bile Acids and Salts; Biliary Tract Diseases; Blind Loop Syndrome; Celiac Disease; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholic Acids; Deoxycholic Acid; Diarrhea; Glycine; Humans; Intestinal Absorption; Intestinal Obstruction; Lithocholic Acid; Liver; Liver Circulation; Oxalates; Stomach Ulcer; Taurine

Topics: Bile Acids and Salts; Cohort Studies; Colonic Neoplasms; Deoxycholic Acid; Duodenal Ulcer; Feces; Female; Gastrectomy; Humans; Lithocholic Acid; Male; Risk Factors; Sex Factors; Stomach Ulcer; Vagotomy, Truncal

Ursodeoxycholic acid (UDCA) has been used in the medical treatment of various gastrointestinal diseases. In this study, UDCA-supplemented rats were investigated to elucidate the role of UDCA in the pathogenesis of gastric mucosal lesions induced by water immersion restraint stress. In UDCA-administered rats, the increase of gastric mucosal lipid peroxide (LOP) and ulcer index after 2 hour's stress were prevented as compared with the rats fed on standard diet to serve as the control. In addition, the increase of serum and gastric mucosal catalase after the stress were also suppressed. These results suggested that antioxidant effect of UDCA on the lipid peroxidation may play a role in prevention of gastric lesions induced by water immersion restraint stress.

Topics: Animals; Deoxycholic Acid; Immersion; Lipid Peroxidation; Male; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach Ulcer; Stress, Physiological; Ursodeoxycholic Acid

Topics: Action Potentials; Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acids; Deoxycholic Acid; Dogs; Gastric Mucosa; Stomach Ulcer

Although recent clinical reports suggest that greater than normal amounts of dihydroxy secondary bile acids appear in the gastric content of patients with postoperative alkaline reflux gastritis, the pathophysiologic significance of these observations is unclear. We addressed this problem by usiong chambered ex vivo wedges of proximal canine gastric wall. The effects of 1 and 2 mM concentrations of the dihydroxy secondary bile acid, taurodeoxycholic, were compared with those of its parent trihydroxy primary bile acid, taurocholic. The parameters of mucosal function evaluated included the net flux of hydrogen ion, the transmural electrical potential difference, mucosal blood flow determined by radiolabeled microsphere embolization, and the severity of mucosal damage induced in mucosa rendered ischemic by wedge-specific intra-arterial low-dose vasopressin infusin. The results indicate that at each concentration in both ischemic and nonischemic mucosa the dihydroxy secondary bile acid induced a greater depression in potential difference, a more profound increase in mucosal permeability to hydrogen ion, and in ischemic mucosa a more severe degree of gross mucosal damage than did the trihydroxy primary bile acid. These effects may be related to a greater lipid solubility and consequent capacity to disrupt cell membranes.

Topics: Animals; Deoxycholic Acid; Dogs; Female; Gastric Mucosa; Ischemia; Male; Stomach Ulcer; Taurocholic Acid; Taurodeoxycholic Acid

During the last years bile acids have gained more and more clinical importance. They play a decisive part in intestinal fat resorption. Increased bile acid content in the colon will result in diarrhea. By determination of serum bile acids the liver function can be judged exactly. It seems probable that bile acids take part in the pathogenesis of gastritis gastric ulcer and colonic cancer. By administration of chenodeoxycholic acid and ursodeoxycholic acid dissolution of cholesterol stones within the gall bladder is possible.

Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Colonic Neoplasms; Deoxycholic Acid; Gastritis; Humans; Intestinal Absorption; Liver Diseases; Oxalates; Stomach Ulcer

Topics: Animals; Deoxycholic Acid; Dogs; Gastric Mucosa; Stomach Ulcer; Taurocholic Acid; Taurodeoxycholic Acid

Reflux of duodenal contents into the stomach has been implicated in the disruption of mucosal defence and the subsequent occurrence of gastric ulcer. The change produced in the rheological properties following the addition of bile salts and phospholipids to mucus samples was used to assess resultant structural changes. Sodium deoxycholate, sodium taurodeoxycholate, sodium glycocholate, and lysophosphatidylcholine decreased both viscosity and elasticity, indicating that structural breakdown had occurred, whereas phosphatidylcholine could not be shown to have any effect. It is therefore suggested that some of the ulcerogenic activity of naturally occurring surfactants may be associated with their ability directly to reduce mucus consistency.

Topics: Bile Acids and Salts; Compliance; Deoxycholic Acid; Glycocholic Acid; Humans; Mucus; Phosphatidylcholines; Sodium Dodecyl Sulfate; Stomach Ulcer; Taurodeoxycholic Acid; Viscosity

Topics: Adult; Aged; Bile; Bile Acids and Salts; Cholesterol; Deoxycholic Acid; Duodenal Ulcer; Female; Gallbladder; Humans; Male; Middle Aged; Stomach Neoplasms; Stomach Ulcer