deoxycholic-acid and Periodontitis

THE HEALING of a new attachment procedures was evaluated in monkeys. Standard flap curettage procedures were made in posterior segments having previously created periodontal pockets. The diseased root surfaces were treated with sodium deoxycholate (2%) and human plasma fraction Cohn IV1 (5%), applied to experimental sites for 1 minute each. Control surfaces were similarly treated with phosphate buffered saline. The healing at 10 weeks postoperatively was described clinically, histologically, and by histometrics. There was a significant increase in connective tissue new attachment in experimental sites, compared to controls.

Topics: Animals; Bicuspid; Blood Proteins; Deoxycholic Acid; Macaca fascicularis; Male; Molar; Periodontal Pocket; Periodontitis; Sodium Chloride; Surgical Flaps; Time Factors; Tooth Root; Wound Healing

The healing of a new attachment procedure was evaluated in monkeys. Standard pedicle wounds similar to reverse bevel flaps were made in previously created periodontal pockets. The diseased root surfaces were treated with sodium deoxycholate (2%) and human plasma fraction Cohn IV (5%), applied to experimental sites for 1 minute each. Control surfaces were similarly treated with phosphate buffered physiological saline. The healing from the first to the 21st day was described (1) clinically, (2) histologically, (3) by rupture strength, and (4) by collagen production assays. All control sites healed with a dentogingival junction comprised only of junctional epithelium. Most experimental sites healed by means of junctional epithelium and some connective tissue new attachment at the apical extent of the wounds.

Topics: Animals; Blood Proteins; Deoxycholic Acid; Epithelial Attachment; Gingiva; Incisor; Macaca mulatta; Periodontal Pocket; Periodontitis; Time Factors; Tooth Root; Wound Healing