deoxycholic-acid and Jaundice

Ursodeoxycholic acid (UDCA) was administered to 16 intrahepatic cholestasis patients with severe jaundice, and its clinical effects were studied. As a result, it was remarkably effective in 6 patients, significantly effective in 5 patients, slightly effective in 2 patients and unchanged in 3 patients. As for the dose, when 600 mg/day was administered, it was effective in all patients, but even when only 150 mg/day was administered, it was effective in one patient (50%). Duration of treatment was 15 to 177 days with a mean of 55.3 days. These results suggested that while there is no adequate treatment for intrahepatic cholestasis with severe jaundice, UDCA should be considered as a possible method of treatment.

Topics: Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Deoxycholic Acid; Dose-Response Relationship, Drug; Female; Humans; Jaundice; Male; Middle Aged; Ursodeoxycholic Acid

Topics: Acute Disease; Adolescent; Adult; Aged; Bile Acids and Salts; Cholelithiasis; Cholestasis; Chromatography, Gas; Chromatography, Ion Exchange; Deoxycholic Acid; Hepatitis A; Humans; Jaundice; Lithocholic Acid; Mass Spectrometry; Middle Aged