deoxycholic-acid and Intestinal-Polyps

Topics: Adenoma, Bile Duct; Bile Acids and Salts; Chenodeoxycholic Acid; Cholesterol, Dietary; Cholic Acids; Clinical Trials as Topic; Deoxycholic Acid; Female; Humans; Intestinal Absorption; Intestinal Polyps; Intestine, Large; Male

Bile acids have been implicated in carcinogenesis of the large bowel, and since epidemiological, clinical and histopathological studies suggest a link between adenomatous polyps and cancer of the large bowel, fecal bile acid profiles were studied in 33 patients with adenomatous polyps of the large bowel and these data were analyzed with particular reference to the distribution, multiplicity, size and degree of dysplasia of the polyps. The more polyps and the greater the severity of dysplasia, the higher was the excretion of total bile acids (mean mumol/day: single vs multiple polyps, 344.8 vs 369.1; mild vs moderate vs severe dysplasia, 347.5 vs 370.0 vs 399.3). However, in patients with larger polyps, total fecal bile acid excretion tended to be lower (mean mumol/day: large vs small polyps, 267.7 vs 389.5). These differences were not statistically significant. When fecal bile acid profiles were analyzed with respect to the extent of bacterial metabolism determined from the degree of dehydroxylation and oxidoreduction, there was a large variation with no consistency in relation to the factors studied among the polyp patients. Deconjugation of bile acids in feces was almost complete without difference among the patients. These results seem to indicate that the significance of bile acid in the development of adenomatous polyps in Japanese subjects is likely to be small.

Topics: Adult; Aged; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Deoxycholic Acid; Feces; Female; Humans; Intestinal Polyps; Intestine, Large; Japan; Lithocholic Acid; Male; Middle Aged; Neoplasms, Multiple Primary; Rectal Neoplasms; Rectum; Statistics as Topic

Bile acids are thought to be involved in both the aetiology and development of colorectal cancer. In this study the existence of specific bile acid receptor proteins has been postulated. A receptor assay which involved labelling with 14C-deoxycholic acid was performed as well as autoradiography using 3H-deoxycholic acid. In an initial study resected colorectal cancer and adjacent histologically normal colorectal mucosa from 39 patients were studied, as were samples of normal gastric mucosa, cancers and benign colorectal tumours. Specific receptors to deoxycholic acid were detected in 12 (30.8 per cent) of the colorectal cancers, but in only 1 (2.6 per cent) of the samples from normal colorectal mucosa (X2 = 11.16, P less than 0.005). No deoxycholic acid receptors were detected in any other tissue studied. Autoradiographs of colorectal cancers showed binding of 3H-deoxycholic acid in receptor-positive tumour tissue. These findings might provide some explanation for the evidence linking bile acids with the disease.

Topics: Autoradiography; Colonic Neoplasms; Deoxycholic Acid; Gastric Mucosa; Humans; Intestinal Polyps; Receptors, Cell Surface; Receptors, Steroid; Rectal Neoplasms; Stomach Neoplasms

Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholestanol; Cholesterol; Cholic Acids; Colectomy; Colonic Neoplasms; Deoxycholic Acid; Feces; Humans; Ileum; Intestinal Polyps; Lithocholic Acid; Neoplasms, Multiple Primary; Rectum; Sterols; Syndrome