deoxycholic-acid and Intestinal-Obstruction

Topics: Bile Acids and Salts; Biliary Tract Diseases; Blind Loop Syndrome; Celiac Disease; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholic Acids; Deoxycholic Acid; Diarrhea; Glycine; Humans; Intestinal Absorption; Intestinal Obstruction; Lithocholic Acid; Liver; Liver Circulation; Oxalates; Stomach Ulcer; Taurine

A 67-year-old Japanese man underwent enterotomy because of enterolith ileus. Component analysis by infrared spectroscopy revealed that the enterolith was composed of a high concentration of deoxycholic acid. We further analyzed and compared the ultrastructure of the enterolith and a commercially available powdered form of deoxycholic acid by means of scanning electron microscopy and energy dispersive X-ray spectroscopy. Energy dispersive X-ray spectroscopy analysis revealed that the ratios of carbon and oxygen in the enterolith were equal to those in the deoxycholic acid powder. Scanning electron microscopy analysis showed rectangular prism-shaped particles on the surface of the enterolith. This structure was similar to that of the deoxycholic acid powder. The surgically removed enterolith had a twisted and coiled appearance. Possible mechanisms underlying the formation of this unique form are discussed.

Topics: Aged; Calculi; Deoxycholic Acid; Digestive System Surgical Procedures; Humans; Intestinal Obstruction; Intestine, Small; Male; Microscopy, Electron, Scanning; Spectrometry, X-Ray Emission; Tomography, X-Ray Computed; Treatment Outcome

Bile acids are detergents with a direct effect on the endotoxin lipopolysaccharide molecule in vitro. This study investigates the effect of orally administered sodium deoxycholate on the survival of rats in the state of ileus. First observations indicated, that the administration of sodium deoxycholate results in a longer survival time. The results are explained by the antiendotoxic (detergent) effect of bile acids.

Topics: Animals; Colonic Diseases; Deoxycholic Acid; Female; Intestinal Obstruction; Prognosis; Rats; Rats, Inbred Strains

The intraluminal changes of bile acids were studied in 42 patients with intestinal obstruction, treated from 1978-1982. Twenty-two patients received surgical treatment and twenty were treated conservatively. Bile acid analysis of the intestinal contents was performed by thin-layer and gas-liquid chromatography. A marked reduction of bile acid concentration was observed before treatment. A decreased percentage of deoxycholic acid, a lowered G : T ratio, and presence of deconjugated bile acids were also present. After relief and/or removal of the obstruction, the concentration of bile acids, the percentage of deoxycholic acid, and the G : T ratio increased. Bile acid deconjugation decreased immediately after surgical treatment but was not affected by conservative treatment. We conclude that bile acid metabolism is altered quantitatively and qualitatively in patients with an intestinal obstruction.

Topics: Aged; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acids; Deoxycholic Acid; Female; Glycine; Humans; Intestinal Obstruction; Male; Taurine

Topics: Calculi; Deoxycholic Acid; Enteritis; Humans; Intestinal Obstruction; Jejunum; Medical Records; Radiation Injuries