deoxycholic-acid has been researched along with Choline-Deficiency* in 2 studies
2 other study(ies) available for deoxycholic-acid and Choline-Deficiency
| Article | Year |
|---|---|
Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model.
Previous findings on hepatic bile acid compositions in nonalcoholic fatty liver disease (NAFLD) have been inconsistent and complicated. The aim of this study was to investigate the effects of steatosis on hepatic bile acid composition in a hypertensive NAFLD model without obesity and diabetes mellitus and compare hepatic bile acid composition between hypertensive rats with and without steatosis.. Two groups of hypertensive rats were studied: spontaneously hypertensive rats (SHR) fed with a normal diet (SHR-N) or a choline-deficient diet (SHR-CD). Two groups of normotensive rats were studied: Wistar Kyoto rats (WKY) fed a normal diet (WKY-N) or a choline-deficient diet (WKY-CD). Hepatic bile acid analysis was performed using liquid chromatography-electrospray ionization-tandem mass spectrometry.. Regarding bile acid composition, the hyodeoxycholic acid (HDCA) species in the SHR-CD group showed the largest change in bile acid composition, significantly decreasing to 21.9% of that found in the SHR-N group. In the WKY-CD group, no reduction of HDCA species was observed.. We demonstrated that the decrease in HDCA species was the main alteration in a hypertensive NAFLD model. It was suggested that the decrease in HDCA species in the SHR-CD group was caused by dysbiosis. Topics: Animals; Bile Acids and Salts; Choline Deficiency; Chromatography, Liquid; Deoxycholic Acid; Disease Models, Animal; Hypertension; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2019 |
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
Female adult rats were as responsive as males to initiation by diethylnitrosamine (DEN) as measured by numbers of GST-P positive hepatocytes appearing early, and do develop hepatocellular cancers. However, when females and males were exposed to four promotion regimens including orotic acid (OA), choline deficiency, deoxycholic acid (DOC), or selection for resistance (to 2-acetylaminofluorene; 2-AAF) after DEN initiation, very significant sex differences were observed with respect to oval cell proliferation and growth rates of hepatocytic foci. These results suggest that responses to promotion such as growth of foci and oval cell proliferation can accompany carcinogenesis but may not be essential to the development of hepatocellular cancer. Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Orotic Acid; Rats; Rats, Inbred F344; Sex Factors | 1990 |