deoxycholic-acid and Celiac-Disease

Topics: Bile Acids and Salts; Biliary Tract Diseases; Celiac Disease; Chenodeoxycholic Acid; Cholelithiasis; Cholestasis; Cholic Acids; Colonic Neoplasms; Deoxycholic Acid; Diarrhea; Humans; Intestinal Diseases; Intestine, Small; Lipid Metabolism; Lithocholic Acid; Liver; Liver Circulation; Malabsorption Syndromes; Portal System

Topics: Bile Acids and Salts; Biliary Tract Diseases; Blind Loop Syndrome; Celiac Disease; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholic Acids; Deoxycholic Acid; Diarrhea; Glycine; Humans; Intestinal Absorption; Intestinal Obstruction; Lithocholic Acid; Liver; Liver Circulation; Oxalates; Stomach Ulcer; Taurine

Perfusion studies of the normal human jejunum were performed to test whether dihydroxy bile acids and hydroxy fatty acids inhibit the absorption of oleic acid, since previous reports documented their inhibitory effects on the absorption of several other organic solutes. 3 mM deoxycholate and 7 mM glycodeoxycholate inhibited the absorption of 3 mM oleic acid in isotonic micellar solutions while inducing net fluid secretion. Similarly, fractional absorption of oleic acid decreased in the presence of hydroxy fatty acids. However, only the changes induced by 2 mM ricinoleic acid could be distinguished from changes induced by an increase in total fatty acid concentration. Under all experimental conditions, close linear relationships existed between net water movement and fractional absorption of glucose, xylose, and fatty acids, as well as between the absorption rates of these solutes. In contrast, net fluid secretion induced by hypertonic D-mannitol (450 mosmol/liter) had no effect on solute absorption. Our data and observations in the literature do not allow formulation of a hypothesis which would adequately define all effects of dihydroxy bile acids and fatty acids on intestinal transport processes. The observations help explain the malabsorption of fat and other nutrients in patients with the blind loop syndrome.

Topics: Adult; Biological Transport, Active; Blind Loop Syndrome; Celiac Disease; Clinical Trials as Topic; Deoxycholic Acid; Glucose; Humans; Intestinal Absorption; Jejunum; Male; Oleic Acids; Ricinoleic Acids; Stearic Acids; Water; Xylose

Topics: Adult; Aged; Celiac Disease; Deoxycholic Acid; Diarrhea; Dietary Fats; Feces; Female; Humans; Intestine, Small; Jejunum; Lipid Metabolism; Male; Micelles; Middle Aged; Ursodeoxycholic Acid

Topics: Adult; Bicarbonates; Bile Acids and Salts; Biopsy; Celiac Disease; Deoxycholic Acid; Dietary Fats; Digestion; Endoplasmic Reticulum; Glycocholic Acid; Humans; Inclusion Bodies; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Intubation, Gastrointestinal; Jejunum; Male; Microscopy, Electron

The size and composition of the bile salt pool has been measured in patients with untreated coeliac disease and in control subjects. The total bile salt pool was markedly increased in coeliac patients, the average being 9.2 grams compared with 3.1 grams in controls. Taurocholate synthesis was normal, consistent with its enlarged pool and prolonged half-life. Half-life and pool size were significantly correlated. The composition of the bile salt pool was virtually identical in the two groups. Our findings suggest that as the enterohepatic circulation is slowed by gallbladder inertia, so hepatic surveillance of pool size is diminished.

Topics: Adult; Bile Acids and Salts; Carbon Isotopes; Celiac Disease; Chenodeoxycholic Acid; Chromatography, Thin Layer; Deoxycholic Acid; Glycine; Half-Life; Humans; Liver Circulation; Taurocholic Acid