dentatin has been researched along with Stomach-Ulcer* in 1 studies
1 other study(ies) available for dentatin and Stomach-Ulcer
| Article | Year |
|---|---|
Anti-ulcerogenic activity of dentatin from clausena excavata Burm.f. against ethanol-induced gastric ulcer in rats: Possible role of mucus and anti-oxidant effect.
Clausena excavata Burm.f. (Rutaceae) has been used for the treatment of stomach disorders including peptic ulcer.. In this study, we aimed to investigate dentatin isolated from C. excavata Burm.f., for anti-ulcer activity against ethanol ulcer model in rats.. Gastric acid output, ulcer index, serum profile, histological evaluation using Hematoxylin and eosin (HE), periodic acid Schiff base stainings and immunohistochemical localization for heat shock proteins 70 (HSP70) were all investigated. Possible involvement of reduced glutathione (GSH), lipid peroxidation, prostaglandin E. Dentatin showed anti-secretory activity against the pylorus ligature model and protected the gastric mucosa from ethanol ulceration, as revealed by the improved macroscopic and histological appearance. Dentatin significantly increased the gastric homogenate content of PGE. Dentatin possesses gastro-protective activity, which could be attributed to the anti-secretory, mucus production, anti-oxidant, and HSP70 activities. Topics: Animals; Anti-Ulcer Agents; Antioxidants; Clausena; Ethanol; Female; Gastric Mucosa; Glutathione; Helicobacter pylori; Heterocyclic Compounds, 3-Ring; HSP70 Heat-Shock Proteins; Lipid Peroxidation; Male; Malondialdehyde; Mucus; Rats, Sprague-Dawley; Stomach Ulcer; Superoxide Dismutase | 2019 |