denbufylline has been researched along with Muscle Relaxation in 3 studies
denbufylline: structure given in first source
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " When compounds were intraduodenally administered to the guinea pig, 1-(2'-ethoxyethyl)-, 1-(3'-methoxypropyl)-, 1-(3'-butenyl)-, and 1-[(dimethylamino)-ethyl]-3-propylxanthines, 1-methyl-7-(2'-oxopropyl)-3-propylxanthine, and denbufylline (1,3-di-n-butyl-7-(2'-oxopropyl)xanthine) effectively inhibited the acetylcholine-induced bronchospasm without heart stimulation or central nervous system-stimulation at the effective dosage range." | 3.68 | Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. ( Hasegawa, T; Iwasaki, N; Konno, K; Kurita, M; Miyamoto, K; Ohshima, T; Sakai, R; Sanae, F; Takagi, K; Yamamoto, Y, 1993) |
| " Among them, 3,4-dipropyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-i]-purin-5-one (1c), which was the most selective and potent PDE IV inhibitor, did not cause emesis in Suncus murinus at a dosage range of 10-100 mg/kg (po), while an imidazole analogue of 1c (4c) and known PDE IV inhibitors such as rolipram and denbufylline caused emesis even at 10 or 30 mg/kg." | 1.30 | Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. ( Kasugai, S; Miyamoto, K; Ohya, K; Sawanishi, H; Suzuki, H; Suzuki, N; Takagi, K; Waki, Y; Yamamoto, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyamoto, K | 2 |
| Yamamoto, Y | 1 |
| Kurita, M | 1 |
| Sakai, R | 1 |
| Konno, K | 1 |
| Sanae, F | 1 |
| Ohshima, T | 1 |
| Takagi, K | 2 |
| Hasegawa, T | 1 |
| Iwasaki, N | 1 |
| Sawanishi, H | 1 |
| Suzuki, H | 1 |
| Yamamoto, S | 1 |
| Waki, Y | 1 |
| Kasugai, S | 1 |
| Ohya, K | 1 |
| Suzuki, N | 1 |
| Ellis, JL | 1 |
| Conanan, ND | 1 |
3 other studies available for denbufylline and Muscle Relaxation
| Article | Year |
|---|---|
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.
Topics: Administration, Oral; Animals; Bronchial Spasm; Bronchodilator Agents; Guinea Pigs; Heart Rate; Male | 1993 |
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiester | 1997 |
Modulation of relaxant responses evoked by a nitric oxide donor and by nonadrenergic, noncholinergic stimulation by isozyme-selective phosphodiesterase inhibitors in guinea pig trachea.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Atropine; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Ph | 1995 |