demethyleneberberine and Hepatitis--Autoimmune

demethyleneberberine has been researched along with Hepatitis--Autoimmune* in 1 studies

Other Studies

1 other study(ies) available for demethyleneberberine and Hepatitis--Autoimmune

Article	Year
Demethyleneberberine attenuates concanavalin A-induced autoimmune hepatitis in mice through inhibition of NF-κB and MAPK signaling. International immunopharmacology, 2020, Volume: 80 Demethyleneberberine (DMB) is a natural product which has been reported to possess mitochondria-targeting anti-oxidative and anti-inflammatory effect. However, the pharmacological action and molecular mechanism of DMB on autoimmune hepatitis (AIH) have not been explored. In this study, AIH was induced by intravenously injecting Con A (20 mg/kg) in mice for 8 h, and DMB protected against Con A-induced AIH, evidenced by obvious reduction of hepatic enzymes in serum and histological lesion. DMB significantly inhibited the infiltration of CD4 Topics: Animals; Berberine; Concanavalin A; Cytokines; Hepatitis, Autoimmune; Liver; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Signal Transduction; Transcription Factor RelA	2020

Article

Year

Demethyleneberberine attenuates concanavalin A-induced autoimmune hepatitis in mice through inhibition of NF-κB and MAPK signaling.

International immunopharmacology, 2020, Volume: 80

Demethyleneberberine (DMB) is a natural product which has been reported to possess mitochondria-targeting anti-oxidative and anti-inflammatory effect. However, the pharmacological action and molecular mechanism of DMB on autoimmune hepatitis (AIH) have not been explored. In this study, AIH was induced by intravenously injecting Con A (20 mg/kg) in mice for 8 h, and DMB protected against Con A-induced AIH, evidenced by obvious reduction of hepatic enzymes in serum and histological lesion. DMB significantly inhibited the infiltration of CD4

Topics: Animals; Berberine; Concanavalin A; Cytokines; Hepatitis, Autoimmune; Liver; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Signal Transduction; Transcription Factor RelA

2020