demethylcantharidin and Lung-Neoplasms

demethylcantharidin has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for demethylcantharidin and Lung-Neoplasms

Article	Year
Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety. Journal of medicinal chemistry, 2001, Jun-21, Volume: 44, Issue:13 A combination of demethylcantharidin, a modified component of a traditional Chinese medicine (TCM), with a platinum moiety has produced a series of TCM-based platinum compounds [Pt(C(8)H(8)O(5))(NH(2)R)(2)] 1-5, which demonstrate selective cytotoxicity toward SK-Hep-1 (human liver) cell line, and circumvention of cross-resistance. The inclusion of demethylcantharidin rendered the compounds highly active as protein phosphatase (PP2A) inhibitors. The new TCM-Pt compounds may possess a novel dual mechanism of antitumor action: inhibition of PP2A and platination of DNA. Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Non-Small-Cell Lung; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Humans; Leukemia L1210; Liver Neoplasms, Experimental; Lung Neoplasms; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Phosphoprotein Phosphatases; Phytotherapy; Plants, Medicinal; Tumor Cells, Cultured	2001

Article

Year

Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety.

Journal of medicinal chemistry, 2001, Jun-21, Volume: 44, Issue:13

A combination of demethylcantharidin, a modified component of a traditional Chinese medicine (TCM), with a platinum moiety has produced a series of TCM-based platinum compounds [Pt(C(8)H(8)O(5))(NH(2)R)(2)] 1-5, which demonstrate selective cytotoxicity toward SK-Hep-1 (human liver) cell line, and circumvention of cross-resistance. The inclusion of demethylcantharidin rendered the compounds highly active as protein phosphatase (PP2A) inhibitors. The new TCM-Pt compounds may possess a novel dual mechanism of antitumor action: inhibition of PP2A and platination of DNA.

Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Non-Small-Cell Lung; Cell Division; DNA, Neoplasm; Enzyme Inhibitors; Humans; Leukemia L1210; Liver Neoplasms, Experimental; Lung Neoplasms; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Phosphoprotein Phosphatases; Phytotherapy; Plants, Medicinal; Tumor Cells, Cultured

2001