demecolcine and Carcinoma--Basal-Cell

Topics: Administration, Topical; Carcinoma, Basal Cell; Clinical Trials as Topic; Demecolcine; Drug Evaluation; Facial Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Ointments; Radiotherapy Dosage; Skin Neoplasms

The authors report the results of clinical elaboration and testing of the technic of intraesophageal intratumor sarcolysin iontophoresis associated with radiotherapy in 40 inoperable patients with cancer of the thoracic esophagus. A total focal dose of irradiation was on the average 1/3 less compared with the routine one. Iontophoresis was performed by a specially designed electrode with 5-10 mA during 60 minutes. The iontophoresis procedure was followed by irradiation. The immediate good results of the treatment were twice as frequent as in control groups. The treatment proceeded with less pronounced radiation response. An average survival of patients while using chemical drugs intophoresis proved to be equal to control data that is likely to be due to the far-advanced stage of the disease in most patients. An average survival in patients with less tumor proliferation was found to be longer than in analogous control series.

Topics: Adult; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Papillary; Carcinoma, Squamous Cell; Demecolcine; Drug Therapy, Combination; Esophageal Neoplasms; Evaluation Studies as Topic; Female; Humans; Iontophoresis; Male; Melphalan; Middle Aged; Radiotherapy Dosage; Time Factors

The topical application of demecolcine (Colcemid, N-desacetyl methyl colchicine), N-desacetyl thiocolchicine (Thio-Colciran), and methotrexate preferably in combination, exerts a selectively destructive action on rodent (basal cell) carcinomas, solar keratoses, Bowen's disease, and keratoacanthomas, while sparing surrounding normal tissues. The former two exert their action by inhibiting mitosis in the metaphase, and the latter inhibits the commencement of mitosis by interference with the synthesis of desoxyribonucleic acid. The cosmetic results are particularly good when the ears or nose are affected, and the cure rate compares favorably with that resulting from other treatments. Although ineffective against squamous carcinomas, the fact that this form of therapy is effective for keratoacanthomas could prove a valuable additional diagnostic point between the two in doubtful cases.

Topics: Administration, Topical; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bowen's Disease; Carcinoma, Basal Cell; Colchicine; Demecolcine; Humans; Keratoacanthoma; Methotrexate; Precancerous Conditions; Skin Neoplasms; Triaziquone

Topics: Carcinoma, Basal Cell; Colchicine; Demecolcine; Hamartoma Syndrome, Multiple; Humans; Skin

Topics: Carcinoma; Carcinoma, Basal Cell; Colchicine; Demecolcine; Humans; Skin Neoplasms

Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colchicine; Demecolcine; Dermatology; Humans; Skin Diseases; Skin Neoplasms

Topics: Carcinoma; Carcinoma, Basal Cell; Cell- and Tissue-Based Therapy; Colchicine; Demecolcine; Humans; Neoplasms, Glandular and Epithelial; Skin Neoplasms