demeclocycline and Water-Electrolyte-Imbalance

Topics: Adult; Aged; Ascites; Demeclocycline; Diuresis; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Water-Electrolyte Imbalance

Hyponatraemia is a very common medical condition that is associated with multiple poor clinical outcomes and is often managed suboptimally because of inadequate assessment and investigation. Previously published guidelines for its management are often complex and impractical to follow in a hospital environment, where patients may present to divergent specialists, as well as to generalists.. A group of senior, experienced UK clinicians, met to develop a practical algorithm for the assessment and management of hyponatraemia in a hospital setting. The latest evidence was discussed and reviewed in the light of current clinical practicalities to ensure an up-to-date perspective. An algorithm was largely developed following consensus opinion, followed up with subsequent additions and amendments that were agreed by all authors during several rounds of review.. We present a practical algorithm which includes a breakdown of the best methods to evaluate volume status, simple assessments for the diagnosis of the various causes and a straightforward approach to treatment to minimise complexity and maximise patient safety.. The algorithm we have developed reflects the best available evidence and extensive clinical experience and provides practical, useable guidance to improve patient care.

Topics: Algorithms; Anti-Bacterial Agents; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Demeclocycline; Fluid Therapy; Hospitalization; Humans; Hyponatremia; Inappropriate ADH Syndrome; Practice Guidelines as Topic; Tolvaptan; Water-Electrolyte Imbalance

Three instances of inappropriate ADH syndrome following craniofacial operations are reported. The cornerstone to diagnosis is careful fluid and electrolyte monitoring. Treatment consists of fluid restrictions in the acute phase and demeclocycline for refractory cases. Seizures should be symptomatically treated. Surgeons involved in the care of craniofacial anomalies must be aware of this syndrome because the symptoms closely mimic those commonly observed following intracranial procedures. If unrecognized, the consequence is potentially lethal.

Topics: Child; Demeclocycline; Face; Female; Humans; Inappropriate ADH Syndrome; Male; Skull; Surgery, Plastic; Water-Electrolyte Imbalance

Three patients with tuberculous meningitis complicated by hypersecretion of anti-diuretic hormone are described. The recognition of this complication is important in the treatment and prognosis of tuberculous meningitis.

Topics: Adult; Demeclocycline; Female; Humans; Inappropriate ADH Syndrome; Male; Tuberculosis, Meningeal; Unconsciousness; Water-Electrolyte Imbalance

Topics: Demeclocycline; Female; Humans; Hyponatremia; Hypothyroidism; Inappropriate ADH Syndrome; Middle Aged; Vasopressins; Water-Electrolyte Imbalance

Topics: Demeclocycline; Heart Failure; Humans; Male; Middle Aged; Natriuresis; Water-Electrolyte Imbalance

3 cases of inappropriate vasopressin secretion during one case of anaplastic carcinoma of the lung, one case of carcinoma of the prostate with bony metastases and one case of acute intermittent porphyria are presented. The plasma levels of vasopressin, measured by radioimmunoassay were high. Treatment with demeclocycline was attempted in one case. The clearance of free water was positive but the treatment was poorly tolerated by the digestive tract.

Topics: Acute Disease; Aged; Carcinoma; Demeclocycline; Female; Humans; Lung Neoplasms; Male; Paraneoplastic Endocrine Syndromes; Porphyrias; Prostatic Neoplasms; Syndrome; Vasopressins; Water-Electrolyte Imbalance

Topics: Adenocarcinoma, Bronchiolo-Alveolar; Aged; Demeclocycline; Humans; Lung Neoplasms; Male; Vasopressins; Water-Electrolyte Imbalance

Topics: Alcoholism; Demeclocycline; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Water-Electrolyte Imbalance

Topics: Ascites; Demeclocycline; Humans; Hyponatremia; Liver Cirrhosis; Natriuresis; Water-Electrolyte Imbalance