demeclocycline and Urethritis

In a double-blind comparison of two regimens of triple tetracycline (Deteclo, Lederle) in the treatment of nongonococcal urethritis, 68 (88.6%) of 70 patients treated with one tablet twice for 21 days and seen four weeks after starting therapy had satisfactory results. This was significantly better than the findings among the 73 patients treated with one tablet twice daily for seven days and followed for four weeks, among whom only 47 (64.4%) had satisfactory results. Results were also better for the group treated with the 21-day regimen at three months afer the start of treatment. When analysed individually at four and 12 weeks, urethral discharge, urethral Gram-stained smears, and first-glass urine test all gave similar results, which were markedly better than those before treatment. It appears that the longer course of treatment it indicated where any regular partner may not be treated. Slightly fewer patients had satisfactory results among those who admitted consuming alcohol than among those who did not. Chlamydiae-negative patients, treated for seven days, had fewer clinically satisfactory results than other sub-groups.

Topics: Chlamydia trachomatis; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Random Allocation; Recurrence; Tetracycline; Time Factors; Urethritis

Details are given of a double-blind trial involving 400 cases in which tetracycline 500 mg. four times a day for 7 days was compared with tetracycline 250 mg. four times a day for 14 days and also of the findings in 311 cases treated with Deteclo 300 mg. three times a day for 3 weeks. The treatment in the double-blind trial were equally effective and appeared to be as effective as the long-term Deteclo therapy. When the results of these treatments were compared with those obtained previously with tetracycline 250 mg. four times a day for 4 days and allowance was made for the time at which the latter results have been assessed, it was concluded that neither the treatment used in the double-blind trial nor Deteclo 300 mg. three times a day for 3 weeks offered any advantage over the customary treatment with tetracycline 250 mg, four times a day for 4 days.

Topics: Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Humans; Oxytetracycline; Tetracycline; Tetracyclines; Time Factors; Urethritis

Topics: Anti-Bacterial Agents; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; England; Erythromycin; Humans; Leucomycins; Male; Tetracycline; Troleandomycin; Urethritis; Wales

Topics: Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline; Contact Tracing; Demeclocycline; Doxycycline; Drug Therapy, Combination; Erythromycin; Humans; Male; Ofloxacin; Recurrence; Tetracycline; Urethritis

Topics: Administration, Oral; Anemia, Hemolytic; Blood-Brain Barrier; Chlortetracycline; Demeclocycline; Doxycycline; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; Gonorrhea; Humans; Injections, Intramuscular; Intestinal Absorption; Male; Methacycline; Minocycline; Oxytetracycline; Penicillins; Tetracycline; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Drug Combinations; Humans; Male; Middle Aged; Oxytetracycline; Tetracycline; Time Factors; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Chlortetracycline; Demeclocycline; Diarrhea; Drug Combinations; Gonorrhea; Humans; Male; Metoclopramide; Microbial Sensitivity Tests; Nausea; Promazine; Recurrence; Tetracycline; Urethritis; Vomiting

Topics: Adolescent; Adult; Aged; Bacteria; Child; Cystitis; Demeclocycline; Female; Humans; Male; Middle Aged; Photosensitivity Disorders; Prostatitis; Pyelonephritis; Time Factors; Urethritis; Urinary Tract Infections; Urine

Topics: Acute Disease; Adolescent; Adult; Demeclocycline; Gonorrhea; Humans; Urethritis

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Chlortetracycline; Demeclocycline; Humans; Male; Middle Aged; Oxytetracycline; Penicillins; Streptomycin; Urethritis

Topics: Adolescent; Adult; Aged; Brazil; Demeclocycline; Female; Gonorrhea; Humans; Male; Urethritis

Topics: Demeclocycline; Gonorrhea; Humans; Penicillins; Urethritis

Topics: Anti-Bacterial Agents; Demeclocycline; Humans; Protein Synthesis Inhibitors; Tetracycline; Urethritis

Topics: Acute Disease; Chlortetracycline; Demeclocycline; Gonorrhea; Urethritis