demeclocycline and Skin-Neoplasms

We describe the clinical, radiographic, histologic, and metabolic features of an unusual case of multiple miliary osteoma cutis in an otherwise healthy 57-year-old woman. Although the pathogenesis of this rarely reported entity is not fully understood, the novel application of a dynamic bone study revealed a high rate of internal bone remodeling within the lesion. This finding prompted a brief therapeutic trial of a diphosphonate, not previously reported in the treatment of this condition.

Topics: Bone and Bones; Calcification, Physiologic; Demeclocycline; Female; Humans; Middle Aged; Neoplasms, Multiple Primary; Osteoma; Oxytetracycline; Skin Neoplasms

Topics: Aged; Biopsy; Chlorambucil; Demeclocycline; Diagnosis, Differential; Humans; Lymphoma; Male; Microscopy, Electron; Mycosis Fungoides; Prednisone; Skin; Skin Neoplasms

Long-term control of mycosis fungoides in the tumour stage was achieved in one patient by daily demethylchlortetracycline therapy. On two occasions widespread nodules and tumours completely involuted within 1 month of initiating this therapy. A second patient showed complete resolution of his plaque stage mycosis fungoides after the institution of oral griseofulvin therapy for a chronic fungus infection. The disease reappeared upon stopping the griseofulvin and involuted upon its resumption. The observations are interpreted as evidence that reduction or eradication of a persistent bacterial or fungal antigen may have a remarkable ameliorative effect in selected mycosis fungoides patients.

Topics: Demeclocycline; Follow-Up Studies; Griseofulvin; Humans; Male; Middle Aged; Mycosis Fungoides; Skin Neoplasms

Topics: Demeclocycline; Fluorescence; Humans; Neoplasms; Paraganglioma; Skin Neoplasms