demeclocycline and Respiratory-Tract-Infections

Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Demeclocycline; Disease Outbreaks; Ecology; Erythromycin; Female; Humans; Infant; Male; Middle Aged; Mycoplasma Infections; Periodicity; Pneumonia; Respiratory Tract Infections; Sex Factors

A systematic review examining the efficacy of antibiotics in acute respiratory illness concluded that antibiotics are of little benefit. However, that review was based on analysis of only six randomized controlled trials, one of which was excluded because its analysis included patients with multiple episodes of illness; treatment group, either antibiotic or placebo, might have confounded the likelihood of suffering a subsequent episode of illness.. This previously excluded randomized controlled trial of 301 patients with symptoms of minor respiratory illness was re-analysed to examine the efficacy of antibiotic versus placebo in terms of resolution of symptoms, most particularly cough.. Antibiotic had no impact on the resolution of symptoms of cough at 1 and 2 weeks, respectively; adjusted odds ratio 1.2 [95% confidence interval (CI) 0.7--2.1] and 0.8 (95% CI 0.4--1.6). In those 220 (73%) individuals who suffered a cough, 48 (44%) and 19 (17%) of patients taking placebo were still coughing after 1 and 2 weeks, respectively.. It appears that an antibiotic is likely to have, at best, a marginal impact on resolution of symptoms for most patients with minor respiratory illness in the community.

Topics: Adult; Anti-Bacterial Agents; Confounding Factors, Epidemiologic; Cough; Demeclocycline; Humans; Male; Middle Aged; Respiratory Tract Infections; Rhinitis; Smoking; Sputum; Suppuration; Time Factors; Treatment Outcome

Seven-day courses of either pivmecillinam 200 mg plus pivampicillin 250 mg (Miraxid) or a combination of tetracycline hydrochloride, chlortetracycline hydrochloride and demeclocycline hydrochloride (Deteclo) 300 mg, both given twice daily, were compared in a multicentre general practice study in 408 patients with symptoms of upper or lower respiratory tract infection. Patients were stratified into four diagnostic groups: sinusitis, otitis media, throat infections, and acute bronchitis and randomly allocated to treatment within these groups. Assessment at 7 days showed no difference in clinical efficacy between the two treatments where 193 of the 208 infections receiving Miraxid (93%) were rated as either cured or improved compared with 181 of the 201 infections treated with Deteclo (90%). At 7 days, the percentage of patients completely free of symptoms was the same for both groups (66%). The mean time for symptoms to clear was 3.9 days in the Miraxid group and 4.0 days in the Deteclo group. Side-effects were reported by significantly fewer patients in the Miraxid group (9.3%) than the Deteclo group (17.5%) (p less than 0.05) and six patients in the latter group failed to complete the course of treatment. Miraxid given twice daily for respiratory tract infections is as effective as Deteclo but causes significantly fewer side-effects.

Topics: Adolescent; Adult; Aged; Amdinocillin; Amdinocillin Pivoxil; Ampicillin; Bronchitis; Child; Chlortetracycline; Demeclocycline; Drug Combinations; Family Practice; Female; Humans; Male; Middle Aged; Otitis Media; Pharyngeal Diseases; Pivampicillin; Respiratory Tract Infections; Sinusitis; Tetracycline

Topics: Adult; Aged; Anti-Infective Agents; Clinical Trials as Topic; Demeclocycline; Female; Folic Acid Antagonists; Humans; Male; Middle Aged; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Trimethoprim

Topics: Anti-Infective Agents; Clinical Trials as Topic; Demeclocycline; Drug Synergism; Folic Acid Antagonists; Humans; Pyrimidines; Respiratory Tract Infections; Sulfamethoxazole; Trimethoprim

Topics: Absenteeism; Adult; Ampicillin; Chronic Disease; Clinical Trials as Topic; Common Cold; Demeclocycline; Drug Synergism; Humans; Information Systems; Male; Middle Aged; Nasal Mucosa; Placebos; Punched-Card Systems; Respiratory Tract Infections; Smoking; Sputum; Surveys and Questionnaires; Time Factors

Topics: Adolescent; Adult; Chlortetracycline; Clinical Trials as Topic; Demeclocycline; Female; Humans; Male; Middle Aged; Respiratory Tract Infections; Tetracycline; Urinary Tract Infections

Topics: Acute Disease; Clinical Trials as Topic; Demeclocycline; Disease Outbreaks; Humans; Placebos; Pneumonia; Radiography; Respiratory Tract Infections

Topics: Demeclocycline; Heart Failure; Hyponatremia; Inappropriate ADH Syndrome; Lung Neoplasms; Respiratory Tract Infections; Water Deprivation

Topics: Adolescent; Adult; Chlortetracycline; Demeclocycline; Drug Combinations; Female; Humans; Male; Middle Aged; Respiratory Tract Infections; Tetracycline

Topics: Demeclocycline; Humans; Respiratory Tract Infections

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Demeclocycline; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Otitis; Pharyngitis; Respiratory Tract Infections; Rhinitis

Topics: Child; Child, Preschool; Demeclocycline; Female; Humans; Impetigo; Infant; Lymphangitis; Male; Peritonsillar Abscess; Pharyngitis; Respiratory Tract Infections; Staphylococcal Infections; Streptococcal Infections; Suspensions; Tonsillitis

Topics: Bronchitis; Child; Child, Preschool; Demeclocycline; Female; Humans; Infant; Male; Pharyngitis; Respiratory Tract Infections; Staphylococcal Infections; Streptococcal Infections; Suspensions; Tonsillitis

Topics: Bronchitis; Child; Child, Preschool; Demeclocycline; Female; Humans; Infant; Male; Meningococcal Infections; Neisseria; Pharyngitis; Respiratory Tract Infections; Staphylococcal Infections; Streptococcal Infections; Suspensions; Tonsillitis

Topics: Bronchitis; Bronchopneumonia; Child; Child, Preschool; Demeclocycline; Diarrhea, Infantile; Female; Humans; Infant; Male; Pharyngitis; Respiratory Tract Infections; Suspensions

Topics: Adolescent; Adult; Aged; Animals; Blood Proteins; Chemical Phenomena; Chemistry; Demeclocycline; Female; Humans; Male; Mice; Microbial Sensitivity Tests; Middle Aged; Respiratory Tract Infections; Staphylococcal Infections; Tetracycline

Topics: Adolescent; Adult; Aged; Blood Sedimentation; Chlortetracycline; Demeclocycline; Female; Humans; Leukocyte Count; Male; Middle Aged; Neutrophils; Respiratory Tract Infections; Tablets; Tetracycline

Topics: Asthma; Child; Child, Preschool; Demeclocycline; Female; Humans; Infant; Male; Respiratory Tract Infections; Sinusitis; Tonsillitis; Triamcinolone

Topics: Adult; Animals; Child; Demeclocycline; Humans; Mice; Oxytetracycline; Respiratory Tract Infections; Skin Diseases, Infectious; Tetracycline; Urinary Tract Infections

Topics: Adult; Chlorpropamide; Cystic Fibrosis; Demeclocycline; Diabetes Mellitus; Diagnosis, Differential; Drug Therapy; Humans; Muscle Relaxants, Central; Physical Therapy Modalities; Radiography, Thoracic; Respiratory Function Tests; Respiratory Tract Infections

Topics: Carrier State; Child; Demeclocycline; Dosage Forms; Drug Resistance; Drug Resistance, Microbial; Humans; Penicillin G; Penicillin V; Pharyngitis; Pharynx; Phosphates; Potassium; Respiratory Tract Infections; Streptococcal Infections; Tetracycline; Tonsillitis

Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Chloramphenicol; Demeclocycline; Drug Therapy; Empirical Research; Infant; Infant, Newborn; Infections; Respiratory Tract Infections

Topics: Demeclocycline; Drug Therapy; Humans; Lung Diseases; Respiratory Tract Infections

Topics: Chlortetracycline; Demeclocycline; Humans; Respiratory Tract Infections; Tuberculosis; Tuberculosis, Pulmonary

Topics: Biomedical Research; Demeclocycline; Humans; Respiratory Tract Infections; Tonsillitis

Topics: Demeclocycline; Erythromycin; Humans; Infant; Otitis Media; Respiratory Tract Infections; Sodium Dodecyl Sulfate