demeclocycline and Mental-Disorders

Hyponatremia has been reported to occur in approximately 5% of carbamazepine-treated patients who otherwise do well on that agent. Demeclocycline has been used in the treatment of hyponatremia of various etiologies including one case of carbamazepine-induced hyponatremia.. We extended these observations by studying the effects of demeclocycline on carbamazepine-induced hyponatremia in six psychiatric inpatients.. Once serum sodium concentrations had normalized after carbamazepine discontinuation, demeclocycline prevented further decreases in sodium levels upon rechallenge with carbamazepine in five of six patients. Gender, smoking, and neurologic compromise may have played a role in the development of carbamazepine-induced hyponatremia as well as response to this strategy, although our sample size is too small to make firm conclusions.. Demeclocycline was successfully used in the prophylaxis of carbamazepine-induced hyponatremia and may be useful in cases that respond best to carbamazepine treatment.

Topics: Adult; Aged; Carbamazepine; Demeclocycline; Drug Therapy, Combination; Female; Hospitalization; Humans; Hyponatremia; Male; Mental Disorders; Middle Aged; Sodium

Topics: Demeclocycline; Humans; Hyponatremia; Mental Disorders; Water Intoxication

Psychiatric patients presenting with chronic psychogenic polydipsia are often difficult to treat with standard psychiatric interventions. Pharmacologic intervention was attempted in three patients and was successful in one. One patient had a significant and sustained reduction of water intake while on 160 mg of propranolol. One patient did not improve with either propranolol or captopril while a third patient showed no improvement of serum sodium with demeclocycline nor reduction of water intake with propranolol. The potential mechanisms by which these pharmacologic agents might alter thirst in patients with primary polydipsia are discussed.

Topics: Adult; Captopril; Demeclocycline; Drinking Behavior; Humans; Inappropriate ADH Syndrome; Male; Mental Disorders; Middle Aged; Propranolol

The syndrome of hyponatremia in psychiatric patients is described, and cases associated with psychotropic drug treatment are reviewed. The causative role of the drug should be documented by rechallenge or a water loading test. In some instances it is possible to continue psychotropic treatment by restricting fluids or administering demeclocycline.

Topics: Adult; Child; Demeclocycline; Humans; Hyponatremia; Inappropriate ADH Syndrome; Infant; Mental Disorders; Psychotropic Drugs