demeclocycline has been researched along with Kidney-Diseases* in 11 studies
1 review(s) available for demeclocycline and Kidney-Diseases
Article | Year |
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The tetracyclines.
Topics: Absorption; Acne Vulgaris; Bacteria; Bacteriuria; Bronchial Diseases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlortetracycline; Demeclocycline; Drug Eruptions; Humans; Infections; Kidney Diseases; Methacycline; Oxytetracycline; Protein Binding; Tetracycline; Tooth Discoloration | 1970 |
10 other study(ies) available for demeclocycline and Kidney-Diseases
Article | Year |
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Plasma demeclocycline levels and nephrotoxicity. Correlation in hyponatremic cirrhotic patients.
In five hyponatremic, cirrhotic patients, demeclocycline hydrochloride was used to inhibit the hydroosmotic effect of vasopressin. In four, renal impairment developed during the 7 to 20 days of demeclocycline hydrochloride (900 to 1,200 mg/day) administration. In these four patients, creatinine clearance fell (72 to 20 mL/min, P less than .01) as BUN (12 to 47 mg/dl, P less than .02) and serum creatinine (0.9 to 4.2 mg/dl, P less than .01) levels rose. The azotemic effect of the drug could not be accounted for consistently by volume depletion secondary to its natriuretic effect. However, a close correlation between plasma demeclocycline levels and its azotemic effect was observed. We conclude that a nephrotoxic effect of demeclocycline severly limits its usefulness in treating hyponatremia in the cirrhotic patient. Topics: Adult; Creatinine; Demeclocycline; Glomerular Filtration Rate; Humans; Hyponatremia; Kidney; Kidney Diseases; Liver Cirrhosis, Alcoholic; Male; Natriuresis; Vasopressins | 1980 |
Renal effects of demeclocycline.
Topics: Demeclocycline; Glomerular Filtration Rate; Humans; Hyponatremia; Kidney; Kidney Diseases; Natriuresis | 1980 |
Renal failure associated with demeclocycline in cirrhosis.
Three patients with cirrhosis, ascites, and dilutional hyponatremia were treated with demeclocycline in an attempt to correct the abnormal water retention. Demeclocycline administration (600 to 900 mg/day for 8 to 9 days) resulted in [a] increased blood urea nitrogen and plasma creatinine concentrations; [b] reduction of the inulin clearance by between 63% to 78% and of paraaminophippurate clearance by 36% to 77%; and [c] an impairment of the renal concentrating ability. Urine osmolality decreased to hypotonic levels, but polyuria did not appear, probably because it was prevented by the reduction of the glomerular filtration rate. Renal failure was reversible on withdrawal of demeclocycline. No other causes than demeclocycline administration could be found to explain the reduction of the glomerular filtration rate and the estimated renal plasma flow. Topics: Blood Urea Nitrogen; Demeclocycline; Glomerular Filtration Rate; Kidney; Kidney Diseases; Kidney Tubules; Liver Cirrhosis; Regional Blood Flow | 1977 |
[Diagnosis and pathophysiology of renal concentration disorders].
Topics: Demeclocycline; Diabetes Insipidus; Diabetes Mellitus; Diuretics; Fanconi Syndrome; Humans; Hypercalcemia; Kidney Concentrating Ability; Kidney Diseases; Lithium; Methoxyflurane; Nephrocalcinosis; Potassium Deficiency | 1976 |
Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion.
We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion. Topics: Carcinoma, Small Cell; Demeclocycline; Diabetes Insipidus; Humans; Hyponatremia; Kidney Diseases; Lung Neoplasms; Male; Middle Aged; Osmolar Concentration; Syndrome; Urine; Vasopressins | 1975 |
Nephrogenic diabetes insipidus secondary to declomycin.
Topics: Adult; Biopsy; Bronchitis; Demeclocycline; Diabetes Insipidus; Female; Humans; Kidney Diseases; Middle Aged; Pneumococcal Infections | 1974 |
Targets for tetracyclines.
Topics: Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Demeclocycline; Dogs; Female; Humans; Kidney Diseases; Male; Methacycline; Oxytetracycline; Photosensitivity Disorders; Pregnancy; Tetracycline; Tooth Calcification; Tooth Discoloration | 1968 |
Nephrogenic diabetes insipidus induced by demethylchlortetracycline (Declomycin).
Topics: Adult; Demeclocycline; Diabetes Insipidus; Female; Humans; Kidney Diseases | 1967 |
NEPHROGENIC DIABETES INSIPIDUS DUE TO DEMETHYLCHLORTETRACYCLINE HYDROCHLORIDE.
Topics: Demeclocycline; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diagnosis; Drug Therapy; Humans; Kidney Diseases; Photosensitivity Disorders; Toxicology; Vasopressins | 1965 |
TOXIC EFFECTS OF THE TETRACYCLINES.
Topics: Anti-Bacterial Agents; Black People; Chemical and Drug Induced Liver Injury; Chlortetracycline; Demeclocycline; Female; Hepatitis; Hepatitis A; Humans; Kidney Diseases; Liver; Maternal-Fetal Exchange; Oxytetracycline; Pharmacology; Pregnancy; Pregnancy Complications; Tetracycline; Tetracyclines; Tooth; Toxicology; Urine | 1964 |