demeclocycline and Heart-Failure

We examined renal function and Na+ balance in a patient with congestive heart failure who was treated with demeclocycline (DMC) on three separate occasions under strict metabolic balance conditions. Natriuresis and reversible renal insufficiency, which could not be explained solely on the basis of negative Na+ balance, developed on each occasion. In contrast to reports of an association between elevated serum DMC levels and renal insufficiency in patients with cirrhotic edema, the renal insufficiency in this patient with cardiac edema occurred in the absence of high DMC levels. Consequently, markedly elevated serum DMC levels do not appear to be a prerequisite for the development of natriuresis or renal insufficiency in edematous patients receiving this drug. In an attempt to clarify the mechanism of the natriuresis, we also examined the effects of DMC on Na+ transport in an in-vitro model system, the toad urinary bladder. DMC inhibited aldosterone-stimulated Na+ transport, but had no effect on Na+ transport when the latter was jointly stimulated by ADH and theophylline. Despite this selective inhibition of the natriferic effect of aldosterone in vitro, it is unlikely that such a mechanism completely accounts for the natriuresis observed in-vivo since the natriuresis is generally of large magnitude and is usually accompanied by some degree of kaliuresis, and DMC had no consistent effect on urinary aldosterone excretion. Consequently, other mechanisms must be sought to explain the natriuretic effect of DMC in edematous patients. Likewise, mechanisms other than negative Na+ balance (perhaps primary alterations in renal hemodynamics) must underly the development of renal insufficiency in such individuals.

Topics: Administration, Oral; Aldosterone; Animals; Anura; Biological Transport; Blood Urea Nitrogen; Body Weight; Demeclocycline; Glomerular Filtration Rate; Heart Failure; Humans; In Vitro Techniques; Kidney Failure, Chronic; Male; Middle Aged; Natriuresis; Nephrons; Potassium; Sodium; Theophylline; Vasopressins

Topics: Adult; Aged; Demeclocycline; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis

A patient with long-standing ischaemic heart disease and severe low output congestive cardiac failure received numerous diuretics, which gradually became ineffective. Resistant oedema was treated by adding demeclocycline to the current diuretic regime of frusemide and metolazone. Diuresis resulted, oedema disappeared and body weight fell. This drug combination was continued without complication for a further 6 months until his death.

Topics: Demeclocycline; Diuretics; Drug Therapy, Combination; Edema; Heart Failure; Humans; Male; Middle Aged

Topics: Demeclocycline; Heart Failure; Hyponatremia; Inappropriate ADH Syndrome; Lung Neoplasms; Respiratory Tract Infections; Water Deprivation

Topics: Demeclocycline; Heart Failure; Humans; Male; Middle Aged; Natriuresis; Water-Electrolyte Imbalance

Topics: Demeclocycline; Glucose; Heart Failure; Humans; Hyponatremia; Insulin; Potassium

Topics: Body Weight; Demeclocycline; Diuresis; Edema, Cardiac; Heart Failure; Humans; Natriuresis

Topics: Demeclocycline; Diuresis; Heart Failure; Humans; Osmolar Concentration; Sodium