demeclocycline and Dentin--Secondary

Vital pulp therapy for cariously exposed permanent teeth remains one of the most controversial areas in dentistry. Because a vital, functioning pulp is capable of initiating several defence mechanisms to protect the body from bacterial invasion, it is beneficial to preserve the vitality and health of an exposed pulp rather than replace it with a root filling material following pulp exposure. There is no consensus on the survival rate of formerly cariously exposed pulps. Observation time, judgement criteria, pulpotomy/pulp capping technique and, most importantly, pulpal status at the time of treatment, vary to a great extent amongst studies. In mature teeth, a pulp exposed by caries is usually removed and the root canals are cleaned, shaped and filled. Amongst the methods for preservation of a cariously exposed pulp, partial pulpotomy has yielded a markedly high success rate in young teeth. Major limitations in the success of vital pulp therapy in cariously exposed permanent teeth exist. The lack of predictability and long-term success greatly influence decision-making. The decision-making itself is unreliable primarily due to the difficulty of accurately diagnosing the ability of the pulp to repair. While there are indications for vital pulp therapy in young permanent molars, it must be remembered that ultimately, none of these procedures enjoy the long-term success of complete root canal therapy.

Topics: Age Factors; Aluminum Compounds; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Calcium Compounds; Calcium Hydroxide; Demeclocycline; Dental Caries; Dental Cements; Dental Pulp; Dental Pulp Capping; Dental Pulp Exposure; Dentin, Secondary; Dentition, Permanent; Drug Combinations; Humans; Oxides; Pulpotomy; Silicates; Triamcinolone Acetonide

Topics: Anti-Infective Agents, Local; Clinical Trials as Topic; Demeclocycline; Dental Pulp; Dental Pulp Diseases; Dental Pulp Test; Dentin, Secondary; Humans; Pulpitis; Triamcinolone Acetonide

To determine the rate of formation of tertiary dentine in dogs' teeth, in response to five commonly used lining materials. Also, to record the resulting differences in quality of the formed dentine.. Representatives of five types of materials commonly used in general practice in the UK were placed in deep standardised cavities with a remaining dentine thickness of 400-500 microns, and sealed to the cavo-surface with zinc oxide-eugenol. The daily rate of tertiary dentine formed in response to each material was measured over a period of 119 days using a tetracycline staining method. A concomitant study to show the quality of the formed dentine was undertaken using the same materials and experimental conditions.. There was a significant difference between the rates of tertiary dentine formation for all materials except zinc oxide-eugenol and Ledermix paste. For each material there was a increased rate of tertiary dentine formation in the second period (29-49 days) compared to the first period (0-28 days). This is considered to be due, in part, to a lag period when damaged odontoblasts are differentiating from mesenchymal elements. The rate of tertiary dentine formation in response to all the test materials was always greater than that of normal physiological dentine formation in unprepared teeth. Qualitatively, there was difference in the formed tertiary dentine beneath each material. All the materials caused odontoblast destruction, altered ground substance production and alterations in the calcification process.. None of the materials routinely used at present can be considered to be 'ideal' as odontoblast destruction, altered ground substance production and altered calcification occur beneath zinc oxide-eugenol preparations, calcium hydroxide preparations as well as in response to corticosteroid-containing materials such as Ledermix paste and cement.

Topics: Analysis of Variance; Animals; Calcium Compounds; Calcium Hydroxide; Demeclocycline; Dental Cavity Lining; Dental Pulp; Dentin; Dentin, Secondary; Dentinogenesis; Dogs; Drug Combinations; Eugenol; Formaldehyde; Minerals; Odontoblasts; Oxides; Time Factors; Triamcinolone Acetonide; Zinc Oxide; Zinc Oxide-Eugenol Cement

The effects of Ledermix+calcium hydroxide (Ca(OH)2) or Ca(OH)2 alone on inflamed pulp tissues of dogs were studied. Fifty-nine upper incisor teeth of 10 dogs were used. Class V cavities were prepared and filled with amalgam after placement of decayed dentin particles. After 7 days, the decayed dentin and alloy were removed, and the pulps of the teeth were exposed. Ledermix and Ca(OH)2 mixtures or Ca(OH)2 alone were applied to the cavities. At the end of 7, 30, and 90 days, the teeth were extracted and examined histopathologically. Inflammation was found to be more prevalent in the 7- and 30-day groups that were treated with the Ledermix+Ca(OH)2 combination, whereas fibrosis and necrosis were nearly similar in both groups. In the 90-day groups, no inflammation was seen. No difference between the two 90-day groups with regard to reparative dentin was found.

Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Calcium Hydroxide; Demeclocycline; Dental Pulp Capping; Dentin, Secondary; Dentinogenesis; Dogs; Drug Combinations; Pulpitis; Triamcinolone Acetonide

A quantitative assessment of dentin bridges was conducted on sections prepared from teeth capped with four pulp-capping agents (Bioglass, Life, Demineralized Dentin Matrix, and Teflon) in a micro-swine model. The degree of mineralization of the dentin bridges relative to the adjacent primary dentin was measured using a computer-based image analysis of microradiographs prepared from the sections. The rate of formation of the dentin bridge was measured from fluorescent bands formed in the same sections by a Demeclocycline dentin marker. There were no statistically significant differences in the relative mineral densities of the dentin bridges and the rate of dentin bridge formation under the four pulp-capping agents. These findings support the suggestion that components of the extracellular matrix rather than pulp-capping agents may be important in the formation and mineralization of dentin bridges in repairing dental pulps.

Topics: Analysis of Variance; Animals; Calcium Hydroxide; Ceramics; Demeclocycline; Dental Materials; Dental Pulp; Dental Pulp Capping; Dentin; Dentin, Secondary; Dentinogenesis; Image Processing, Computer-Assisted; In Vitro Techniques; Polytetrafluoroethylene; Swine; Swine, Miniature

An extra oral approach was made to 26 pairs of Wistar rat incisors and a small bur used to expose the pulps which were then dressed with either calcium hydroxide paste (Pulpdent) zinc oxide-eugenol cement (Kalzinol) or a triamocinolone acetonide/tetracycline containing cement (Ledermix). Animals were sacrificed at 7 days, incisors removed, a window cut to the pulp opposite the site of exposure, soft tissues removed with 7% NaOCl for 30 minutes before teeth were dehydrated in graded concentrations of acetone and gold coated for examination under SEM. Calcium hydroxide produced rapid complete repair with a remarkably regular formation of calcospherites, except for a zone of relative inhibition perforated by nutrient canals at the periphery of each lesion. Both zinc oxide-eugenol and triamcinolone acetonide cements inhibited both bridging of the defect created by the exposure and dentine formation in the surrounding pulpal wall. Data was grouped according to the degree of hard tissue repair. The results were statistically significant (Chi-square p < or = 0.001). This method demonstrated qualitative and quantitative differences in the repair process resulting from chemical variations in the dressings applied.

Topics: Animals; Calcium Hydroxide; Chi-Square Distribution; Demeclocycline; Dental Pulp Capping; Dentin, Secondary; Dentinogenesis; Drug Combinations; Eugenol; Formaldehyde; Incisor; Male; Microscopy, Electron, Scanning; Rats; Rats, Wistar; Triamcinolone Acetonide; Zinc Oxide

The rate of tertiary dentin produced in response to four lining materials placed in standardized cavities in dogs' teeth was measured over a period of 119 days. Sterile denatured dentin ash was used as a control material in an attempt to quantify tertiary dentin formation in response to cavity preparation. In all periods the amounts of tertiary dentin formed beneath the control material were significantly smaller than those formed beneath any of the four lining materials. In the first 98 days the rate of formation of tertiary dentin beneath calcium hydroxide (Calxyl) was significantly greater than that beneath the material containing corticosteroid (Ledermix cement). In the last 21 days there was no difference in daily rates of tertiary dentin production beneath all of the lining materials. With all the lining materials there was a highly significant difference between the daily amounts of tertiary dentin formed in the first 6 weeks and those in the last 11 weeks.

Topics: Animals; Calcium Hydroxide; Demeclocycline; Dental Cavity Lining; Dental Cavity Preparation; Dentin; Dentin, Secondary; Dogs; Drug Combinations; Staining and Labeling; Tetracycline; Time Factors; Triamcinolone Acetonide; Zinc Oxide-Eugenol Cement

Topics: Adolescent; Adult; Calcium Hydroxide; Child; Demeclocycline; Dental Pulp; Dentin, Secondary; Drug Combinations; Female; Humans; Male; Pulpitis; Pulpotomy; Triamcinolone Acetonide

Topics: Administration, Topical; Adolescent; Adult; Age Factors; Anti-Inflammatory Agents; Calcium Hydroxide; Child; Demeclocycline; Dental Pulp; Dental Pulp Capping; Dentin, Secondary; Dexamethasone; Drug Combinations; Formaldehyde; Humans; Hydrocortisone; Molar; Pulpotomy; Thymol; Triamcinolone Acetonide; Wound Healing

This article describes a pilot investigation in which the response of the pulps in both sound and carious rat molar teeth to traumatic exposure and treatment with three different compounds was assessed. Two of the compounds appeared to give a more favorable response in carious teeth. These results are discussed, and future experiments described.

Topics: Animals; Calcium Hydroxide; Demeclocycline; Dental Caries; Dental Cavity Lining; Dental Pulp; Dental Pulp Capping; Dentin, Secondary; Drug Combinations; Eugenol; Minerals; Pilot Projects; Rats; Triamcinolone Acetonide; Zinc Oxide

Topics: Demeclocycline; Dental Caries; Dental Materials; Dental Pulp; Dental Pulp Capping; Dentin, Secondary; Humans; Time Factors; Triamcinolone Acetonide

Topics: Demeclocycline; Dental Pulp; Dental Pulp Capping; Dentin, Secondary; Humans; Triamcinolone

Topics: Adrenal Cortex Hormones; Calcium Hydroxide; Demeclocycline; Dental Caries; Dental Pulp Capping; Dentin, Secondary; Humans; Pulpitis; Triamcinolone

Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Demeclocycline; Dental Caries; Dental Cavity Lining; Dental Pulp; Dental Pulp Capping; Dental Pulp Diseases; Dentin, Secondary; Haplorhini; Humans; Penicillins; Phenols; Prednisolone; Silver Nitrate; Triamcinolone; Tritium; Zinc Oxide-Eugenol Cement

Topics: Adolescent; Bicuspid; Calcium Hydroxide; Child; Demeclocycline; Dental Pulp; Dentin, Secondary; Dentinogenesis; Humans; Triamcinolone