demeclocycline and Dental-Caries

Vital pulp therapy for cariously exposed permanent teeth remains one of the most controversial areas in dentistry. Because a vital, functioning pulp is capable of initiating several defence mechanisms to protect the body from bacterial invasion, it is beneficial to preserve the vitality and health of an exposed pulp rather than replace it with a root filling material following pulp exposure. There is no consensus on the survival rate of formerly cariously exposed pulps. Observation time, judgement criteria, pulpotomy/pulp capping technique and, most importantly, pulpal status at the time of treatment, vary to a great extent amongst studies. In mature teeth, a pulp exposed by caries is usually removed and the root canals are cleaned, shaped and filled. Amongst the methods for preservation of a cariously exposed pulp, partial pulpotomy has yielded a markedly high success rate in young teeth. Major limitations in the success of vital pulp therapy in cariously exposed permanent teeth exist. The lack of predictability and long-term success greatly influence decision-making. The decision-making itself is unreliable primarily due to the difficulty of accurately diagnosing the ability of the pulp to repair. While there are indications for vital pulp therapy in young permanent molars, it must be remembered that ultimately, none of these procedures enjoy the long-term success of complete root canal therapy.

Topics: Age Factors; Aluminum Compounds; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Calcium Compounds; Calcium Hydroxide; Demeclocycline; Dental Caries; Dental Cements; Dental Pulp; Dental Pulp Capping; Dental Pulp Exposure; Dentin, Secondary; Dentition, Permanent; Drug Combinations; Humans; Oxides; Pulpotomy; Silicates; Triamcinolone Acetonide

The aim of this clinical trial was to compare the degree of short term post-operative irritation after application of a triamcinolone/demeclocycyline based or a calcium hydroxide based provisional cement.. A total of 109 patients (55 female and 54 male; mean age: 51 ± 14 years) with primary or secondary dentinal caries were randomly assigned to the two treatment groups of this biomedical clinical trial (phase III). Selection criteria were good systemic health and treated teeth, which were vital and showed no symptoms of pulpitis. Up to three teeth were prepared for indirect metallic restorations, and the provisional restorations were cemented with a triamcinolone/demeclocycyline (Ledermix) or a calcium hydroxide (Provicol) based material. The intensity of post-operative pain experienced was documented according to the VAS (4, 12, 20, 24, and 82 h) and compared to VAS baseline.. A total of 159 teeth were treated (Ledermix: 83 teeth, Provicol: 76 teeth). The minor irritation of the teeth, experienced prior to treatment, was similar in both groups; however, 4 h after treatment this value was significantly higher in the Provicol group than in the Ledermix group (p < 0.005, t-test). After 12 h, the difference was no longer significant. The number of patients taking analgesics for post-treatment pain was higher in the Provicol group (n = 11/53) than in the Ledermix group (n = 3/56).. The patients had no long term post-operative pain experience in both groups. However, within the first hours after cementation the sensation of pain was considerably higher in the Provicol group than in the Ledermix group.

Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bone Cements; Calcium Hydroxide; Demeclocycline; Dental Caries; Drug Combinations; Female; Humans; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies; Triamcinolone Acetonide

Topics: Adolescent; Adult; Calcium Hydroxide; Child; Demeclocycline; Dental Caries; Drug Combinations; Humans; Mandible; Molar; Odontogenesis; Pulpitis; Pulpotomy; Random Allocation; Tooth Root; Triamcinolone Acetonide

This article describes a pilot investigation in which the response of the pulps in both sound and carious rat molar teeth to traumatic exposure and treatment with three different compounds was assessed. Two of the compounds appeared to give a more favorable response in carious teeth. These results are discussed, and future experiments described.

Topics: Animals; Calcium Hydroxide; Demeclocycline; Dental Caries; Dental Cavity Lining; Dental Pulp; Dental Pulp Capping; Dentin, Secondary; Drug Combinations; Eugenol; Minerals; Pilot Projects; Rats; Triamcinolone Acetonide; Zinc Oxide

Topics: Adolescent; Child; Demeclocycline; Dental Caries; Dental Pulp; Dental Restoration, Permanent; Drug Combinations; Female; Humans; Pulpotomy; Triamcinolone Acetonide

Topics: Ampicillin; Anti-Bacterial Agents; Cross Reactions; Demeclocycline; Dental Caries; Enterococcus faecalis; Erythromycin; Escherichia coli; Humans; In Vitro Techniques; Penicillin Resistance; Periodontal Diseases; Periodontitis; Staphylococcus

Topics: Demeclocycline; Dental Caries; Dental Materials; Dental Pulp; Dental Pulp Capping; Dentin, Secondary; Humans; Time Factors; Triamcinolone Acetonide

Topics: Adrenal Cortex Hormones; Calcium Hydroxide; Demeclocycline; Dental Caries; Dental Pulp Capping; Dentin, Secondary; Humans; Pulpitis; Triamcinolone

Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Demeclocycline; Dental Caries; Dental Cavity Lining; Dental Pulp; Dental Pulp Capping; Dental Pulp Diseases; Dentin, Secondary; Haplorhini; Humans; Penicillins; Phenols; Prednisolone; Silver Nitrate; Triamcinolone; Tritium; Zinc Oxide-Eugenol Cement

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Child; Demeclocycline; Dental Calculus; Dental Caries; Erythromycin; Female; Fluorescence; Humans; Infant; Oxytetracycline; Pregnancy; Tetracycline; Tetracyclines; Tooth, Deciduous; Toxicology