demeclocycline and Brucellosis

Topics: Adolescent; Anti-Bacterial Agents; Brucellosis; Child; Chloramphenicol; Chlortetracycline; Demeclocycline; Epidemiology; Humans; Immunotherapy, Active; Infant; Italy; Oleandomycin; Statistics as Topic; Streptomycin; Tetracycline

In Canada, about 100 sporadically occurring cases of brucellosis are reported yearly. Three patients were admitted to one Montreal hospital in the first seven months of 1963; all were employed in or around a packing plant. One had pain and electrocardiographic changes suggestive of Brucella myocarditis; he recovered promptly. Symptoms of neurasthenia and anxiety are common and were observed in two of these three cases. Two had positive blood cultures; the third showed conclusive agglutination to Br. abortus (1:10,240). In some patients with frequent previous exposures to infection the agglutination response may be equivocal and difficult to interpret. All three patients responded well to tetracycline; streptomycin and corticosteroids also have a role in the therapy of some cases. There may also be some place for combined antibiotic and vaccine therapy. The program of control of the disease in cattle in Canada is aimed at eradication by 1967.

Topics: Animals; Anti-Bacterial Agents; Antigen-Antibody Reactions; Aspartate Aminotransferases; Brucella; Brucella abortus; Brucellosis; Canada; Cattle; Demeclocycline; Drug Therapy; Electrocardiography; Epidemiology; Hospitals, Veterans; Humans; Male; Meat-Packing Industry; Myocarditis; Occupational Diseases; Pain; Streptomycin; Tetracycline; United States; Veterans; Zoonoses