demeclocycline and Bone-Diseases--Metabolic

A single oral dose of tetracycline deposits in bone and is readily identified with fluorescence microscopy. Two such time-spaced labels can be used to determine bone dynamic features. This is as accurate as conventional three-day labeling periods. The simplicity, improved compliance, and substantial reduction in time it takes to prepare a patient for bone biopsy all appear to be advantageous when compared with current recommendations.

Topics: Adult; Bone and Bones; Bone Diseases, Metabolic; Demeclocycline; Drug Administration Schedule; Growth Plate; Humans; Microscopy, Fluorescence; Middle Aged; Tetracycline