demeclocycline and Abnormalities--Drug-Induced

Topics: Abnormalities, Drug-Induced; Child, Preschool; Chlortetracycline; Demeclocycline; Female; Humans; Infant; Infant, Newborn; Oxytetracycline; Pregnancy; Tetracycline; Tooth Discoloration

Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Barbiturates; Chloramphenicol; Demeclocycline; Female; Fetal Diseases; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meperidine; Oxytetracycline; Pregnancy; Progesterone; Reserpine; Streptomycin; Sulfisoxazole; Tetracycline; Thiouracil; Thyroxine; Toxicology; Vitamin K

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Child; Demeclocycline; Dental Calculus; Dental Caries; Erythromycin; Female; Fluorescence; Humans; Infant; Oxytetracycline; Pregnancy; Tetracycline; Tetracyclines; Tooth, Deciduous; Toxicology

Topics: Abnormalities, Drug-Induced; Child; Communicable Diseases; Demeclocycline; Diseases in Twins; Female; Fluorescence; Humans; Infant; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Tooth Discoloration; Tooth, Deciduous; Toxicology; Twins

A possible relationship between stability of a tetracycline and persistence in the foetal skeleton is discussed; it seems that the greater the stability of a tetracycline, the more it may interfere with bone-forming processes. Therefore, assuming that limited instability does not impair antibiotic potency in vivo, the use of a low-stability tetracycline seems to be a safer form of treatment in order to avoid undesired effects on the foetal skeleton.

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Bone Development; Chelating Agents; Chick Embryo; Chlortetracycline; Demeclocycline; Fetus; Fluorescence; Oxytetracycline; Research; Tetracycline; Toxicology