delta-hemolysin-protein--staphylococcus-aureus and Pruritus

delta-hemolysin-protein--staphylococcus-aureus has been researched along with Pruritus* in 1 studies

Other Studies

1 other study(ies) available for delta-hemolysin-protein--staphylococcus-aureus and Pruritus

Article	Year
Delta Hemolysin and Phenol-Soluble Modulins, but Not Alpha Hemolysin or Panton-Valentine Leukocidin, Induce Mast Cell Activation. Frontiers in cellular and infection microbiology, 2016, Volume: 6 Mast cells are located at host interfaces, such as the skin, and contribute to the first-line defense against pathogens by releasing soluble mediators, including those that induce itching and scratching behavior. Here, we show that delta-hemolysin (Hld) and phenol soluble modulins (PSMs) PSMα1 and PSMα3, but not alpha-hemolysin (Hla) or Panton-Valentine leukocidin (PVL), induce dose-dependent tryptase, and lactate dehydrogenase (LDH) release by the HMC-1 human mast cell line. Using supernatants from isogenic strains, we verified that tryptase and LDH release was Hld- and PSMα-dependent. PSMα1 and Hld production was detected in 65 and 17% of human Topics: Bacterial Proteins; Bacterial Toxins; Cell Line; Exotoxins; Hemolysin Proteins; Humans; Leukocidins; Mast Cells; Oxidoreductases; Pruritus; Staphylococcal Skin Infections; Staphylococcus aureus; Trans-Activators; Tryptases; Up-Regulation; Virulence Factors	2016

Article

Year

Delta Hemolysin and Phenol-Soluble Modulins, but Not Alpha Hemolysin or Panton-Valentine Leukocidin, Induce Mast Cell Activation.

Frontiers in cellular and infection microbiology, 2016, Volume: 6

Mast cells are located at host interfaces, such as the skin, and contribute to the first-line defense against pathogens by releasing soluble mediators, including those that induce itching and scratching behavior. Here, we show that delta-hemolysin (Hld) and phenol soluble modulins (PSMs) PSMα1 and PSMα3, but not alpha-hemolysin (Hla) or Panton-Valentine leukocidin (PVL), induce dose-dependent tryptase, and lactate dehydrogenase (LDH) release by the HMC-1 human mast cell line. Using supernatants from isogenic strains, we verified that tryptase and LDH release was Hld- and PSMα-dependent. PSMα1 and Hld production was detected in 65 and 17% of human

Topics: Bacterial Proteins; Bacterial Toxins; Cell Line; Exotoxins; Hemolysin Proteins; Humans; Leukocidins; Mast Cells; Oxidoreductases; Pruritus; Staphylococcal Skin Infections; Staphylococcus aureus; Trans-Activators; Tryptases; Up-Regulation; Virulence Factors

2016