delta-hemolysin-protein--staphylococcus-aureus and Endocarditis--Bacterial

In a recent landmark trial of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) isolates, vancomycin MICs were >or=1 microg/ml for only 16% of the isolates, and accessory gene regulator (agr) function as measured by delta-hemolysin activity was absent or reduced in only 28.1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure.

Topics: Anti-Bacterial Agents; Bacteremia; Bacterial Proteins; Daptomycin; Endocarditis, Bacterial; Genotype; Hemolysin Proteins; Humans; Methicillin Resistance; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Vancomycin