dehydroxymethylepoxyquinomicin and Chronic-Disease

dehydroxymethylepoxyquinomicin has been researched along with Chronic-Disease* in 1 studies

Other Studies

1 other study(ies) available for dehydroxymethylepoxyquinomicin and Chronic-Disease

ArticleYear
Dehydroxymethylepoxyquinomicin selectively ablates T-CAEBV cells.
    Frontiers in bioscience (Landmark edition), 2015, 01-01, Volume: 20, Issue:3

    Chronic active Epstein-Barr virus infection (CAEBV) represents a new subtype of lymphoproliferative disorders characterized by high morbidity and mortality rates and often leads to malignant transformation of infected cells. Efficient therapeutic strategies are presently unavailable; therefore, the development of therapies to prevent CAEBV-mediated transformation and disease progression is crucial. Here, we used microarray analysis and luciferase reporter assays to reveal the potential role of activated nuclear factor kappa B (NF-kB) in T cell type of-CAEBV infection. Using a series of cellular and molecular experiments, we demonstrated that dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kB inhibitor, can selectively induce apoptosis in SNT-16 cells infected with CAEBV. Mechanistic studies suggested that DHMEQ induces SNT-16 cell apoptosis through NF-kB inhibition coupled with oxidative stress generation. Thus, activated NF-kB could be a new target for CAEBV therapeutics. Owing to its selective targeting ability, DHMEQ may be a candidate for a novel therapeutic regimen to control the progression of CAEBV infections.

    Topics: Apoptosis; Base Sequence; Benzamides; Cells, Cultured; Chronic Disease; Cyclohexanones; DNA Primers; Epstein-Barr Virus Infections; Flow Cytometry; Gene Expression; Humans; NF-kappa B; Oxidative Stress; Real-Time Polymerase Chain Reaction

2015