Compounds > dehydroepiandrosterone
Page last updated: 2024-11-07

dehydroepiandrosterone and Varicocele

dehydroepiandrosterone has been researched along with Varicocele in 9 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Varicocele: A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.

Research Excerpts

ExcerptRelevanceReference
"In the present study we determined progesterone (P), 17-OH-progesterone (17-OH-P), androstenedione (delta 4), dehydroepiandrosterone (DHEA) and testosterone (T) in spermatic venous blood of 34 varicocele patients and of 13 normal subjects."3.67Testosterone precursors in spermatic venous blood of normal men and varicocele patients. A study of delta 4 pathway of testosterone biosynthesis. ( Andò, S; Beraldi, E; Colpi, GM; Giacchetto, C; Panno, ML; Sposato, G, 1985)
"Serum testosterone (T), 17-hydroxyprogesterone (17P), androstenedione (delta 4-dione), dehydroepiandrosterone (DHA), delta 5-androstene-3 beta, 17 beta-diol (delta 5-diol), estradiol (E2), dihydrotestosterone (DHT),5 alpha-androstane-3 alpha,17 beta-diol (3 alpha diol), and 5 alpha-androstane-3 beta,17 beta-diol (3 beta diol) were measured in the peripheral and spermatic venous blood of 21 boys undergoing surgery for idiopathic left varicocele."3.67Spermatic and peripheral venous plasma concentrations of testosterone, 17-hydroxyprogesterone, androstenedione, dehydroepiandrosterone, delta 5-androstene-3 beta,17 beta-diol, dihydrotestosterone, 5 alpha-androstane-3 alpha,17 beta-diol, 5 alpha-androstan ( Adamo, MV; Balducci, R; Casilli, D; Forti, G; Grisolia, GA; Maroder, M; Pampaloni, A; Santoro, S; Serio, M; Toscano, V, 1985)
"As part of an investigation of the role of gonadal steroid concentrations and testicular function, testosterone (T), estradiol (E2) and dehydroepiandrosterone sulfate (DHEA-S) were measured in bilateral testicular biopsies from infertile men with varicoceles."3.66Testicular hormone concentration in men with varicoceles: immediate effects of varicocelectomy. ( Newton, R; Schiff, I; Schinfeld, JS, 1983)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19907 (77.78)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kharbanda, RK1
de Groot, NMS1
Andreas, M1
Arzl, P1
Mitterbauer, A1
Ballarini, NM1
Kainz, FM1
Kocher, A1
Laufer, G1
Wolzt, M1
Forti, G2
Facchinetti, F1
Sardelli, S1
Santoro, S2
Grisolia, GA2
Bassi, F1
Serio, M2
Schinfeld, JS1
Schiff, I1
Newton, R1
Scholler, R1
Nahoul, K1
Castanier, M1
Rotman, J1
Salat-Baroux, J1
Ross, LS1
Andò, S1
Giacchetto, C1
Colpi, GM1
Beraldi, E1
Panno, ML1
Sposato, G1
Toscano, V1
Casilli, D1
Maroder, M1
Balducci, R1
Adamo, MV1
Pampaloni, A1
Kelch, RP1
Jenner, MR1
Weinstein, R1
Kaplan, SL1
Grumbach, MM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacokinetics of a Novel Oral Testosterone Undecanoate Formulation With Concomitant Inhibition of 5alpha-Reductase by Finasteride[NCT00842751]Phase 211 participants (Actual)Interventional2009-07-31Completed
Pharmacokinetics of Modified Slow-Release Oral Testosterone Over 10 Days in Normal Men With Experimental Hypogonadism[NCT01167829]Phase 114 participants (Actual)Interventional2010-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Maximum Testosterone Concentration

Area under the curve of serum testosterone Pharmacokinetic measures time-weighted mean concentration calculated as area under the concentration curve (AUC) divided by time from initiation of dosing for the morning dose and corrected for differences in baseline hormone concentration. (NCT00842751)
Timeframe: 0,1,2,4,8,and 12-hour post dose

Interventionng*hr/dL (Geometric Mean)
Acyline +Testosterone Undecanoate + Placebo471
Acyline +Testosterone Undecanoate + 0.5mg Finasteride444
Acyline +Testosterone Undecanoate + 1mg Finasteride543

Serum Dihydrotestosterone Concentration

Area under the curve of serum dihydrotestosterone (NCT00842751)
Timeframe: 0,1,2,4,8,and 12-hour post dose

Interventionng*hr/dL (Geometric Mean)
Acyline +Testosterone Undecanoate + Placebo154
Acyline + Testosterone Undecanoate + 0.5mg Finasteride118
Acyline + Testosterone Undecanoate + 1mg Finasteride125

Serum Estradiol Concentration

Area under the curve of serum estradiol (NCT00842751)
Timeframe: 0,1,2,4,8,and 12-hour post dose

Interventionng*hr/dL (Geometric Mean)
Acyline +Testosterone Undecanoate + Placebo7.9
Acyline + Testosterone Undecanoate + 0.5mg Finasteride6.5
Acyline +Testosterone Undecanoate + 1mg Finasteride7.2

Free T Maximum Concentration

Free T normal range 4.7-18 ng/dL (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1-2Day 9-10
300 mg Oral Testosterone2421

Free Testosterone Mean Concentration

Free T normal range 4.7-18 ng/dL (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1-2Day 9-10
300 mg Oral Testosterone8.78.3

Maximum Dihydrotestosterone (DHT) Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone233142

Maximum Estradiol Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone149

Maximum Sex Hormone-Binding Globulin (SHGB)Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone3122

Maximum Testosterone Concentration

initial pharmacokinetics [PK] (day 1) of oral testosterone dosed 3 times daily and the PK after 9 days of treatment (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
Acyline and 300 mg Oral Testosterone924741

Mean Dihydrotestosterone (DHT) Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
Acyline and 300 mg Oral Testosterone9669

Mean Estradiol Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone117

Mean SHGB Concentration

(NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
300 mg Oral Testosterone2719

Mean Testosterone Concentration

initial 24-hour pharmacokinetics (PK) of oral testosterone dosed 3 times daily and post 24-hour PK after 9 days of treatment (NCT01167829)
Timeframe: baseline & day 9

Interventionng/dL (Geometric Mean)
Day 1Day 9
Acyine and 300 mg Oral Testosterone378315

Other Studies

9 other studies available for dehydroepiandrosterone and Varicocele

ArticleYear
Letter by Kharbanda and de Groot Regarding Article, "Electrical Stimulation of the Greater Auricular Nerve to Reduce Postoperative Atrial Fibrillation".
    Circulation. Arrhythmia and electrophysiology, 2019, Volume: 12, Issue:12

    Topics: 17-alpha-Hydroxyprogesterone; Androstane-3,17-diol; Androstenediol; Androstenedione; Atrial Fibrilla

2019
Response by Andreas et al to Letter Regarding Article, "Electrical Stimulation of the Greater Auricular Nerve to Reduce Postoperative Atrial Fibrillation".
    Circulation. Arrhythmia and electrophysiology, 2019, Volume: 12, Issue:12

    Topics: 17-alpha-Hydroxyprogesterone; Androstane-3,17-diol; Androstenediol; Androstenedione; Atrial Fibrilla

2019
Spermatic and peripheral venous plasma concentrations of dehydroepiandrosterone sulfate in prepubertal and pubertal boys.
    Journal of steroid biochemistry, 1983, Volume: 18, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Cryptorchidism; Dehydroepiandrosterone; Dehydroepiandrosterone

1983
Testicular hormone concentration in men with varicoceles: immediate effects of varicocelectomy.
    International journal of fertility, 1983, Volume: 28, Issue:3

    Topics: Biopsy; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Humans; Male; Testis; Tes

1983
Testicular secretion of conjugated and unconjugated steroids in normal adults and in patients with varicocele. Baseline levels and time-course response to hCG administration.
    Journal of steroid biochemistry, 1984, Volume: 20, Issue:1

    Topics: Adult; Androstenes; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate;

1984
Routine hormonal screening of infertile men: is it worthwhile?
    The Journal of urology, 1981, Volume: 126, Issue:6

    Topics: 17-Ketosteroids; Dehydroepiandrosterone; Diagnostic Tests, Routine; Hormones; Humans; Hydroxyprogest

1981
Testosterone precursors in spermatic venous blood of normal men and varicocele patients. A study of delta 4 pathway of testosterone biosynthesis.
    Acta endocrinologica, 1985, Volume: 108, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Humans; Hy

1985
Spermatic and peripheral venous plasma concentrations of testosterone, 17-hydroxyprogesterone, androstenedione, dehydroepiandrosterone, delta 5-androstene-3 beta,17 beta-diol, dihydrotestosterone, 5 alpha-androstane-3 alpha,17 beta-diol, 5 alpha-androstan
    The Journal of clinical endocrinology and metabolism, 1985, Volume: 61, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Age Factors; Androstane-3,17-diol; Androstenediol; Androst

1985
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972
Estradiol and testosterone secretion by human, simian, and canine testes, in males with hypogonadism and in male pseudohermaphrodites with the feminizing testes syndrome.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:4

    Topics: Adult; Androgen-Insensitivity Syndrome; Animals; Chorionic Gonadotropin; Chromatography, Thin Layer;

1972