Page last updated: 2024-11-07

dehydroepiandrosterone and Syndrome

dehydroepiandrosterone has been researched along with Syndrome in 23 studies

Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.

Syndrome: A characteristic symptom complex.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study is to confirm the local beneficial effects of intravaginal dehydroepiandrosterone (DHEA, Prasterone) on moderate to severe dyspareunia or pain at sexual activity, the most frequent symptom of vulvovaginal atrophy due to menopause or genitourinary syndrome of menopause (GSM)."9.27Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. ( Archer, DF; Balser, J; BSc, AB; Côté, I; Frenette, L; Koltun, W; Labrie, F; Lavoie, L; Martel, C; Montesino, M; Moyneur, É; Parent, J; Portman, D; Vachon, A; Vaillancourt, M; Young, D, 2018)
"The aim of this study is to confirm the local beneficial effects of intravaginal dehydroepiandrosterone (DHEA, Prasterone) on moderate to severe dyspareunia or pain at sexual activity, the most frequent symptom of vulvovaginal atrophy due to menopause or genitourinary syndrome of menopause (GSM)."9.22Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. ( Archer, DF; Balser, J; Beauregard, A; Côté, I; Frenette, L; Koltun, W; Labrie, F; Lavoie, L; Martel, C; Montesino, M; Moyneur, É; Parent, J; Portman, D; Vachon, A; Vaillancourt, M; Young, D, 2016)
" To understand the influence of hormones on schizophrenia symptoms, serum steroids (estradiol, progesterone, follicular stimulating hormone (FSH), luteinising hormone (LH), and dehydroepiandrosterone (DHEA)) and psychopathology (The positive-and-negative-syndrome-scale(PANSS)) and depression (Montgomery-Asberg-Depression-Rating Scale(MADRS)) were collected across 12-weeks in 45 women (mean age 46) diagnosed with schizophrenia."5.30Dissecting the syndrome of schizophrenia: Associations between symptomatology and hormone levels in women with schizophrenia. ( Gavrilidis, E; Gurvich, C; Hudaib, AR; Kulkarni, J; Thomas, N, 2019)
"The aim of this study is to confirm the local beneficial effects of intravaginal dehydroepiandrosterone (DHEA, Prasterone) on moderate to severe dyspareunia or pain at sexual activity, the most frequent symptom of vulvovaginal atrophy due to menopause or genitourinary syndrome of menopause (GSM)."5.27Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. ( Archer, DF; Balser, J; BSc, AB; Côté, I; Frenette, L; Koltun, W; Labrie, F; Lavoie, L; Martel, C; Montesino, M; Moyneur, É; Parent, J; Portman, D; Vachon, A; Vaillancourt, M; Young, D, 2018)
"The aim of this study is to confirm the local beneficial effects of intravaginal dehydroepiandrosterone (DHEA, Prasterone) on moderate to severe dyspareunia or pain at sexual activity, the most frequent symptom of vulvovaginal atrophy due to menopause or genitourinary syndrome of menopause (GSM)."5.22Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. ( Archer, DF; Balser, J; Beauregard, A; Côté, I; Frenette, L; Koltun, W; Labrie, F; Lavoie, L; Martel, C; Montesino, M; Moyneur, É; Parent, J; Portman, D; Vachon, A; Vaillancourt, M; Young, D, 2016)
" More recently, double-blind, placebo-controlled clinical trials have demonstrated that local vaginal dehydroepiandrosterone improves symptoms in postmenopausal women, including moderate to severe dyspareunia."3.88The role of androgens in the treatment of genitourinary syndrome of menopause (GSM): International Society for the Study of Women's Sexual Health (ISSWSH) expert consensus panel review. ( Archer, DF; Bachmann, G; Davis, SR; Goldstein, AT; Goldstein, I; Kellogg-Spadt, S; Kim, NN; Lowenstein, L; Nappi, RE; Pinkerton, JV; Simon, JA; Stuenkel, CA; Traish, AM; Vignozzi, L, 2018)
"Ospemifene therapy was however superior to laser and vaginal estrogen therapies in ameliorating sexual function, however, it presents a high risk of developing adverse events and endometrial hyperplasia."2.72Efficacy and safety of current therapies for genitourinary syndrome of menopause: A Bayesian network analysis of 29 randomized trials and 8311 patients. ( Chang, Y; Duan, H; Li, B; Wang, S, 2021)
"Patients with breast cancer receiving antiestrogen therapy, specifically aromatase inhibitors, often suffer from vaginal dryness, itching, irritation, dyspareunia, and dysuria, collectively known as genitourinary syndrome of menopause (GSM)."2.61Managing Genitourinary Syndrome of Menopause in Breast Cancer Survivors Receiving Endocrine Therapy. ( Abraham, J; Kruse, ML; Sussman, TA; Thacker, HL, 2019)
"The syndrome was perceived as new, and various explanations were advanced such as factitious disorder, intoxication, or stress."1.38Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress. ( Aronsson, B; Bergquist, J; Kushnir, MM; Sandstedt, P; Söndergaard, HP, 2012)
"Their insulin resistance was significantly greater than that in a control group with comparable obesity."1.27Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history. ( Cavallo, A; Meyer, WJ; Peters, EJ; Prince, MJ; Richards, GE; Smith, ER; Stuart, CA, 1985)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19909 (39.13)18.7374
1990's1 (4.35)18.2507
2000's0 (0.00)29.6817
2010's10 (43.48)24.3611
2020's3 (13.04)2.80

Authors

AuthorsStudies
Stute, P1
Bertschy, S1
Birkhaeuser, M1
Bitzer, J1
Ging, A1
Raggi, A1
Steimann, S1
Stute, V1
Salvatore, S3
Benini, V3
Ruffolo, AF3
Degliuomini, RS3
Redaelli, A3
Casiraghi, A3
Candiani, M3
Thomas, N1
Gurvich, C1
Hudaib, AR1
Gavrilidis, E1
Kulkarni, J1
Li, B1
Duan, H1
Chang, Y1
Wang, S1
Simon, JA1
Goldstein, I1
Kim, NN1
Davis, SR1
Kellogg-Spadt, S1
Lowenstein, L1
Pinkerton, JV1
Stuenkel, CA1
Traish, AM1
Archer, DF3
Bachmann, G1
Goldstein, AT1
Nappi, RE1
Vignozzi, L1
Labrie, F2
Koltun, W2
Vachon, A2
Young, D2
Frenette, L2
Portman, D2
Montesino, M2
Côté, I2
Parent, J2
Lavoie, L2
BSc, AB1
Martel, C2
Vaillancourt, M2
Balser, J2
Moyneur, É2
Yoshihara, T1
Ozaki, H1
Nakagata, T1
Natsume, T1
Kitada, T1
Ishihara, Y1
Sawada, S1
Ishibashi, M1
Kobayashi, H1
Machida, S1
Naito, H1
Sussman, TA1
Kruse, ML1
Thacker, HL1
Abraham, J1
Samaras, N1
Samaras, D1
Frangos, E1
Forster, A1
Philippe, J1
Beauregard, A1
Gandhi, J1
Chen, A1
Dagur, G1
Suh, Y1
Smith, N1
Cali, B1
Khan, SA1
Ghayee, HK1
Rege, J1
Watumull, LM1
Nwariaku, FE1
Carrick, KS1
Rainey, WE1
Miller, WL1
Auchus, RJ1
Söndergaard, HP1
Kushnir, MM1
Aronsson, B1
Sandstedt, P1
Bergquist, J1
SONKA, J2
GREGOROVA, I1
JIRANEK, M1
KOELBEL, F1
MATYS, Z1
Dykes, PJ1
Marks, R1
Harper, PS1
Hiroi, N1
Yakushiji, F1
Shimojo, M1
Watanabe, S1
Sugano, S1
Yamaguchi, N1
Miyachi, Y1
Christiansen, P1
Olofsson, BO1
Grankvist, K1
Boman, K1
Forsberg, K1
Lafvas, I1
Lithner, F1
Richards, GE1
Cavallo, A1
Meyer, WJ1
Prince, MJ1
Peters, EJ1
Stuart, CA1
Smith, ER1
Graf, M1
Distler, W1
Schnürch, HG1
Majewski, F1
Matsumine, H1
Holzmann, H1
Krapp, R1
Hoede, N1
Morsches, B1

Clinical Trials (12)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Selective Estrogen Receptor Modulators (SERMs) - A Potential New Treatment for Women of Child-bearing Age With Psychotic Symptoms of Schizophrenia[NCT02354001]Phase 480 participants (Anticipated)Interventional2011-04-30Completed
Selective Estrogen Receptor Modulators - A Potential Treatment for Psychotic Symptoms of Schizophrenia?[NCT00361543]Phase 454 participants (Actual)Interventional2006-08-31Completed
Open-Label Vulvoscopy Photography Study of Changes in Vulva, Vestibule, Urethral Meatus and Vagina 20 Weeks Post Daily Administration of 6.5 Mg Vaginal Prasterone in Menopausal Women With Moderate to Severe Dyspareunia[NCT03568604]Phase 418 participants (Actual)Interventional2018-08-07Completed
A Review on the Clinical Outcome of Chinese Women With Moderate to Severe Symptoms of Genitourinary Syndrome of Menopause (GSM) Treated With Vaginal Dehydroepiandrosterone (DHEA)[NCT05434351]4 participants (Actual)Observational2022-08-01Terminated (stopped due to inadequate sample and only few patients were prescribed with vaginal DHEA)
Effect of Intravaginal Prasterone (DHEA) on Moderate to Severe Symptoms of Vulvovaginal Atrophy Due to Menopause, in Women Under Treatment With an Aromatase Inhibitor for Breast Cancer - (Placebo-Controlled, Double Blind and Randomized Phase III Study)[NCT03740945]Phase 30 participants (Actual)Interventional2018-11-06Withdrawn (stopped due to Business decision to not perform this study.)
A Placebo-controlled Study Examining the Morphological/Biochemical Effects of Intrarosa on the Vulvar Vestibule and Vagina in Women With Genitourinary Syndrome of Menopause/Vulvovaginal Atrophy[NCT03782480]Phase 340 participants (Anticipated)Interventional2019-03-02Recruiting
A Randomized, Double-blind, Placebo-controlled Trial on the Preventive Effect of Intravaginal Prasterone (DHEA, Intrarosa®) on Recurrent Urinary Tract Infections in Women With Genitourinary Syndrome of Menopause[NCT03854396]Phase 30 participants (Actual)Interventional2020-05-31Withdrawn (stopped due to due to termination of ISR by PI with agreement by grant sponsor)
[NCT02013544]Phase 3558 participants (Actual)Interventional2014-02-28Completed
Compare the Effectiveness and Side Effects of Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause[NCT05483634]40 participants (Anticipated)Observational2022-10-28Not yet recruiting
Effectiveness of C02 Microfractionated Laser in Conjunction With Topical Regenerative Therapy in the Management of Vulvo-vaginal Atrophy in Patients With a History of Breast Cancer. Randomized Experimental and Comparative Study.[NCT05585476]98 participants (Anticipated)Interventional2022-12-31Not yet recruiting
Effects of Vaginal Oxytocin Gel on Vaginal Cytologic Parameters in Postmenopausal Woman: A Randomized Placebo-controlled Trial[NCT05627791]Phase 2/Phase 36 participants (Actual)Interventional2022-11-30Terminated (stopped due to Unable to recuit participant number in time.)
Photobiomodulation Effect on Vulvovaginal Atrophy in Postmenopausal Women: Randomized and Controlled Trial.[NCT04487392]Phase 20 participants (Actual)Interventional2020-12-15Withdrawn (stopped due to The student do not start the study)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline to Week 12 in Percentage of Parabasal Cells in the Maturation Index of the Vaginal Smear

The percentage of parabasal cells was determined from the vaginal smears collected during the study. A 100-cell count was performed by a central laboratory to classify cells as parabasal (P) (including basal), intermediate (I), and superficial (S) squamous cell types. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
InterventionPercentage of parabasal cells (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)54.2512.74-41.51
Placebo51.6639.68-11.98

Change From Baseline to Week 12 in Percentage of Superficial Cells in the Maturation Index of the Vaginal Smear

The percentage of superficial cells was determined from the vaginal smears collected during the study. A 100-cell count was performed by a central laboratory to classify cells as parabasal (P) (including basal), intermediate (I), and superficial (S) squamous cell types. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
InterventionPercentage of superficial cells (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)1.0211.2210.20
Placebo1.042.781.75

Change From Baseline to Week 12 in Severity of the Most Bothersome Symptom of Dyspareunia

The severity of dyspareunia was evaluated by a questionnaire filled out by women. The severity of dyspareunia recorded as none, mild, moderate or severe was analyzed using the score values of 0, 1, 2 or 3, respectively. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
Interventionunits on a scale (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)2.541.13-1.42
Placebo2.561.50-1.06

Change From Baseline to Week 12 in Severity of Vaginal Atrophy as Evaluated From Vaginal Color

To evaluate the aspect of the mucosa and the local tolerance to prasterone ovules, the vaginal color (one of the four main signs of vaginal atrophy) evaluated by the physician/gynecologist as corresponding to none, mild, moderate, or severe atrophy was analyzed using the score values of 1, 2, 3 and 4, respectively. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
Interventionunits on a scale (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)2.752.03-0.73
Placebo2.672.34-0.33

Change From Baseline to Week 12 in Severity of Vaginal Atrophy as Evaluated From Vaginal Epithelial Integrity

To evaluate the aspect of the mucosa and the local tolerance to prasterone ovules, the vaginal epithelial integrity (one of the four main signs of vaginal atrophy) evaluated by the physician/gynecologist as corresponding to none, mild, moderate, or severe atrophy was analyzed using the score values of 1, 2, 3 and 4, respectively. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
Interventionunits on a scale (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)2.451.75-0.69
Placebo2.432.06-0.37

Change From Baseline to Week 12 in Severity of Vaginal Atrophy as Evaluated From Vaginal Epithelial Surface Thickness

To evaluate the aspect of the mucosa and the local tolerance to prasterone ovules, the vaginal epithelial surface thickness (one of the four main signs of vaginal atrophy) evaluated by the physician/gynecologist as corresponding to none, mild, moderate, or severe atrophy was analyzed using the score values of 1, 2, 3 and 4, respectively. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
Interventionunits on a scale (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)2.832.09-0.74
Placebo2.762.41-0.36

Change From Baseline to Week 12 in Severity of Vaginal Atrophy as Evaluated From Vaginal Secretions

To evaluate the aspect of the mucosa and the local tolerance to prasterone ovules, the vaginal secretions (one of the four main signs of vaginal atrophy) evaluated by the physician/gynecologist as corresponding to none, mild, moderate, or severe atrophy were analyzed using the score values of 1, 2, 3 and 4, respectively. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
Interventionunits on a scale (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)2.701.97-0.73
Placebo2.632.24-0.39

Change From Baseline to Week 12 in Severity of Vaginal Dryness

The severity of vaginal dryness was evaluated by a questionnaire filled out by women. The severity of vaginal dryness recorded as none, mild, moderate or severe was analyzed using the score values of 0, 1, 2 or 3, respectively. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
Interventionunits on a scale (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)2.300.86-1.44
Placebo2.301.13-1.17

Change From Baseline to Week 12 in Vaginal pH

A pH strip fixed on an Ayre spatula (or equivalent) was applied directly to the lateral wall of the vagina. The change in color of the pH indicator strip was compared to the color chart for pH evaluation. The corresponding pH value (with one decimal) was recorded. Data obtained at Baseline and Week 12 as well as the change from Baseline to Week 12 are presented. (NCT02013544)
Timeframe: Baseline and Week 12

,
Interventionunits on a scale (Mean)
BaselineWeek 12Change from Baseline to Week 12
0.50% Prasterone (DHEA)6.345.39-0.94
Placebo6.326.05-0.27

Reviews

6 reviews available for dehydroepiandrosterone and Syndrome

ArticleYear
Current challenges in the pharmacological management of genitourinary syndrome of menopause.
    Expert opinion on pharmacotherapy, 2023, Volume: 24, Issue:1

    Topics: Atrophy; Breast Neoplasms; Dehydroepiandrosterone; Estrogens; Female; Humans; Menopause; Quality of

2023
Current challenges in the pharmacological management of genitourinary syndrome of menopause.
    Expert opinion on pharmacotherapy, 2023, Volume: 24, Issue:1

    Topics: Atrophy; Breast Neoplasms; Dehydroepiandrosterone; Estrogens; Female; Humans; Menopause; Quality of

2023
Current challenges in the pharmacological management of genitourinary syndrome of menopause.
    Expert opinion on pharmacotherapy, 2023, Volume: 24, Issue:1

    Topics: Atrophy; Breast Neoplasms; Dehydroepiandrosterone; Estrogens; Female; Humans; Menopause; Quality of

2023
Current challenges in the pharmacological management of genitourinary syndrome of menopause.
    Expert opinion on pharmacotherapy, 2023, Volume: 24, Issue:1

    Topics: Atrophy; Breast Neoplasms; Dehydroepiandrosterone; Estrogens; Female; Humans; Menopause; Quality of

2023
Efficacy and safety of current therapies for genitourinary syndrome of menopause: A Bayesian network analysis of 29 randomized trials and 8311 patients.
    Pharmacological research, 2021, Volume: 164

    Topics: Bayes Theorem; Dehydroepiandrosterone; Estrogens; Female; Female Urogenital Diseases; Humans; Laser

2021
Managing Genitourinary Syndrome of Menopause in Breast Cancer Survivors Receiving Endocrine Therapy.
    Journal of oncology practice, 2019, Volume: 15, Issue:7

    Topics: Aromatase Inhibitors; Breast Neoplasms; Cancer Survivors; Dehydroepiandrosterone; Estrogens; Female;

2019
A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial?
    Rejuvenation research, 2013, Volume: 16, Issue:4

    Topics: Aging; Dehydroepiandrosterone; Humans; Syndrome

2013
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
    American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:6

    Topics: Atrophic Vaginitis; Dehydroepiandrosterone; Dyspareunia; Estrogen Replacement Therapy; Female; Human

2016
[DEHYDROEPIANDROSTERONE DEFICIENCY A NEW SYNDROME?].
    Casopis lekaru ceskych, 1965, Mar-12, Volume: 104

    Topics: Dehydroepiandrosterone; Humans; Metabolic Diseases; Syndrome

1965

Trials

3 trials available for dehydroepiandrosterone and Syndrome

ArticleYear
Dissecting the syndrome of schizophrenia: Associations between symptomatology and hormone levels in women with schizophrenia.
    Psychiatry research, 2019, Volume: 280

    Topics: Adult; Biomarkers; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Humans;

2019
Dissecting the syndrome of schizophrenia: Associations between symptomatology and hormone levels in women with schizophrenia.
    Psychiatry research, 2019, Volume: 280

    Topics: Adult; Biomarkers; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Humans;

2019
Dissecting the syndrome of schizophrenia: Associations between symptomatology and hormone levels in women with schizophrenia.
    Psychiatry research, 2019, Volume: 280

    Topics: Adult; Biomarkers; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Humans;

2019
Dissecting the syndrome of schizophrenia: Associations between symptomatology and hormone levels in women with schizophrenia.
    Psychiatry research, 2019, Volume: 280

    Topics: Adult; Biomarkers; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Humans;

2019
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2018, Volume: 25, Issue:11

    Topics: Adjuvants, Immunologic; Administration, Intravaginal; Adult; Aged; Aged, 80 and over; Atrophy; Dehyd

2018
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:3

    Topics: Administration, Intravaginal; Aged; Dehydroepiandrosterone; Double-Blind Method; Dyspareunia; Female

2016

Other Studies

14 other studies available for dehydroepiandrosterone and Syndrome

ArticleYear
Swiss consensus on the role of DHEA in the management of genitourinary syndrome of menopause.
    Climacteric : the journal of the International Menopause Society, 2022, Volume: 25, Issue:3

    Topics: Atrophy; Consensus; Dehydroepiandrosterone; Female; Female Urogenital Diseases; Humans; Menopause; S

2022
The role of androgens in the treatment of genitourinary syndrome of menopause (GSM): International Society for the Study of Women's Sexual Health (ISSWSH) expert consensus panel review.
    Menopause (New York, N.Y.), 2018, Volume: 25, Issue:7

    Topics: Administration, Intravaginal; Aged; Androgens; Atrophy; Consensus; Dehydroepiandrosterone; Dyspareun

2018
Association between locomotive syndrome and blood parameters in Japanese middle-aged and elderly individuals: a cross-sectional study.
    BMC musculoskeletal disorders, 2019, Mar-14, Volume: 20, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Asian People; Biomarkers; Cross-Sectional Studies; Dehydroepiandrost

2019
Clinical, biochemical, and molecular characterization of macronodular adrenocortical hyperplasia of the zona reticularis: a new syndrome.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:2

    Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenalectomy; Adult; Blotting, Western; Dehydroepi

2011
Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress.
    BMC research notes, 2012, Jun-19, Volume: 5

    Topics: 17-alpha-Hydroxyprogesterone; Activities of Daily Living; Adolescent; Child; Chromatography, Liquid;

2012
Syndrome of ichthyosis, hepatosplenomegaly and cerebellar degeneration--steroid sulphatase activity.
    The British journal of dermatology, 1980, Volume: 102, Issue:3

    Topics: Cerebellar Diseases; Dehydroepiandrosterone; Fibroblasts; Hepatomegaly; Humans; Ichthyosis; Male; Sp

1980
Human ACTH hypersensitivity syndrome associated with abnormalities of the ACTH receptor gene.
    Clinical endocrinology, 1998, Volume: 48, Issue:2

    Topics: Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Aged; Aldosterone; Biomarkers; Corticotr

1998
Urinary gonadotrophins in the Sertoli-Cell-only syndrome.
    Acta endocrinologica, 1975, Volume: 78, Issue:1

    Topics: Adult; Androgens; Androsterone; Biological Assay; Biopsy; Castration; Dehydroepiandrosterone; Dexame

1975
Dehydroepiandrosterone. Metabolic effects.
    Acta Universitatis Carolinae. Medica. Monographia, 1976, Volume: 71

    Topics: Adolescent; Adult; Androgens; Animals; Cell Division; Cell Membrane Permeability; Chemical Phenomena

1976
Assessment of thyroid and adrenal function in patients with familial amyloidotic polyneuropathy.
    Journal of internal medicine, 1989, Volume: 225, Issue:5

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Amyloidosis; Dehydroepiandros

1989
Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history.
    The Journal of pediatrics, 1985, Volume: 107, Issue:6

    Topics: Acanthosis Nigricans; Adolescent; Androstenedione; Body Weight; Child; Dehydroepiandrosterone; Femal

1985
[Ovarian insufficiency in blepharophimosis, ptosis, epicanthus inversus].
    Geburtshilfe und Frauenheilkunde, 1986, Volume: 46, Issue:3

    Topics: Adult; Blepharoptosis; Chromosome Aberrations; Chromosome Disorders; Dehydroepiandrosterone; Eyelids

1986
Accelerated conversion of androgen to estrogen in plasma-cell dyscrasia associated with polyneuropathy, anasarca, and skin pigmentation.
    The New England journal of medicine, 1985, Oct-17, Volume: 313, Issue:16

    Topics: Adult; Androgens; Dehydroepiandrosterone; Edema; Estrogens; Female; Humans; Male; Paraproteinemias;

1985
Exogenous and endogenous provocation of psoriasis. A contribution to the Koebner phenomenon.
    Archiv fur dermatologische Forschung, 1974, Volume: 249, Issue:1

    Topics: Adolescent; Adult; Child; Cyclic AMP; Dehydroepiandrosterone; Female; Foodborne Diseases; Humans; In

1974