dehydroepiandrosterone has been researched along with Sjogren's Syndrome in 15 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum levels of the sex steroid prohormones dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) decline upon aging and are reduced in primary Sjogren's syndrome." | 9.14 | Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. ( Carlsten, H; Forsblad-d'Elia, H; Konttinen, YT; Labrie, F; Ohlsson, C, 2009) |
| "Primary Sjögren's syndrome (SS) is characterized by fatigue and low levels of serum dehydroepiandrosterone/dehydroepiandrosterone sulfate (DHEA/DHEAS)." | 9.14 | Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjögren's syndrome. ( Forsblad-d'Elia, H; Konttinen, YT; Porola, P; Solovieva, SA; Valtysdottir, S; Virkki, LM, 2010) |
| "Dehydroepiandrosterone (DHEA) administration has been reported to improve fatigue, psychological distress, and physical disability." | 9.13 | Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. ( Bijlsma, JW; Bootsma, H; Derksen, RH; Geenen, R; Godaert, GL; Hartkamp, A; Kruize, AA, 2008) |
| "Serum levels of the sex steroid prohormones dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) decline upon aging and are reduced in primary Sjogren's syndrome." | 5.14 | Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. ( Carlsten, H; Forsblad-d'Elia, H; Konttinen, YT; Labrie, F; Ohlsson, C, 2009) |
| "Primary Sjögren's syndrome (SS) is characterized by fatigue and low levels of serum dehydroepiandrosterone/dehydroepiandrosterone sulfate (DHEA/DHEAS)." | 5.14 | Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjögren's syndrome. ( Forsblad-d'Elia, H; Konttinen, YT; Porola, P; Solovieva, SA; Valtysdottir, S; Virkki, LM, 2010) |
| "Dehydroepiandrosterone (DHEA) administration has been reported to improve fatigue, psychological distress, and physical disability." | 5.13 | Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. ( Bijlsma, JW; Bootsma, H; Derksen, RH; Geenen, R; Godaert, GL; Hartkamp, A; Kruize, AA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (66.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Konttinen, YT | 8 |
| Stegajev, V | 1 |
| Al-Samadi, A | 1 |
| Porola, P | 7 |
| Hietanen, J | 2 |
| Ainola, M | 1 |
| Boström, EA | 1 |
| d'Elia, HF | 1 |
| Dahlgren, U | 1 |
| Simark-Mattsson, C | 1 |
| Hasséus, B | 1 |
| Carlsten, H | 2 |
| Tarkowski, A | 1 |
| Bokarewa, M | 1 |
| Virkki, L | 1 |
| Przybyla, BD | 2 |
| Laine, M | 3 |
| Patterson, TA | 1 |
| Pihakari, A | 2 |
| Forsblad-d'Elia, H | 2 |
| Labrie, F | 1 |
| Ohlsson, C | 1 |
| Virkki, LM | 2 |
| Valtysdottir, S | 1 |
| Solovieva, SA | 1 |
| Virtanen, I | 1 |
| Pöllänen, R | 1 |
| Straub, RH | 1 |
| Nordström, DC | 1 |
| Fuellen, G | 1 |
| Bing, Y | 1 |
| Stegaev, V | 1 |
| Trokovic, N | 1 |
| Falk, SS | 1 |
| Liu, Y | 1 |
| Szodoray, P | 1 |
| Takakubo, Y | 1 |
| Brennan, MT | 2 |
| Sankar, V | 2 |
| Leakan, RA | 2 |
| Grisius, MM | 1 |
| Collins, MT | 1 |
| Fox, PC | 2 |
| Baum, BJ | 1 |
| Pillemer, SR | 2 |
| Smith, JA | 1 |
| Grisius, M | 1 |
| Ligier, S | 1 |
| Radfar, L | 1 |
| Kok, MR | 1 |
| Kingman, A | 1 |
| Toivanen, A | 1 |
| van Vollenhoven, R | 1 |
| Hartkamp, A | 1 |
| Geenen, R | 1 |
| Godaert, GL | 1 |
| Bootsma, H | 1 |
| Kruize, AA | 1 |
| Bijlsma, JW | 1 |
| Derksen, RH | 1 |
| Udby, L | 1 |
| Kjeldsen, L | 1 |
| Cowland, JB | 1 |
| Borregaard, N | 1 |
| Ståhle, M | 1 |
| Tóth, E | 1 |
| Horváth, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue[NCT00543166] | Phase 4 | 107 participants (Actual) | Interventional | 2003-02-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dehydroepiandrosterone and Sjogren's Syndrome
| Article | Year |
|---|---|
Sjögren's syndome and extragonadal sex steroid formation: a clue to a better disease control?
Topics: Androgens; Autoimmunity; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dendritic Cells; Di | 2015 |
Sex steroids in Sjögren's syndrome.
Topics: Acinar Cells; Animals; Apoptosis; Dehydroepiandrosterone; Dihydrotestosterone; Estrogens; Exocrine G | 2012 |
[The role of adrenal and gonadal hormones in the pathogenesis of autoimmune polyarthritis].
Topics: Androgens; Arthritis; Arthritis, Rheumatoid; Autoantigens; Chronic Disease; Dehydroepiandrosterone; | 2002 |
6 trials available for dehydroepiandrosterone and Sjogren's Syndrome
| Article | Year |
|---|---|
Salivary resistin reflects local inflammation in Sjögren's syndrome.
Topics: Adjuvants, Immunologic; Adult; Aged; Biomarkers; Case-Control Studies; Dehydroepiandrosterone; Femal | 2008 |
Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Dehydroepiandrosterone; Double-Blind | 2009 |
Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjögren's syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Dehydroepiandrosterone; Fatigue; Fem | 2010 |
Failure of oral DHEA treatment to increase local salivary androgen outputs of female patients with Sjögren's syndrome.
Topics: Adult; Aged; Androgens; Dehydroepiandrosterone; Female; Hormone Replacement Therapy; Humans; Middle | 2011 |
Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjögren's syndrome.
Topics: Adjuvants, Immunologic; Dehydroepiandrosterone; Double-Blind Method; Female; Humans; Middle Aged; Pi | 2004 |
Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial.
Topics: Adult; Affect; Aged; Blood Sedimentation; Chi-Square Distribution; Dehydroepiandrosterone; Dehydroep | 2008 |
6 other studies available for dehydroepiandrosterone and Sjogren's Syndrome
| Article | Year |
|---|---|
Androgen deficiency and defective intracrine processing of dehydroepiandrosterone in salivary glands in Sjögren's syndrome.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adult; Aged; Androgens; Biopsy; | 2008 |
Androgens and integrins in salivary glands in Sjogren's syndrome.
Topics: Adolescent; Adult; Aged; Biopsy; Cell Line; Dehydroepiandrosterone; Female; Gene Expression; Humans; | 2010 |
Sex steroid hormones in primary Sjögren's syndrome.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estrad | 2003 |
Pilot clinical trial of dehydroepiandrosterone for Sjögren's syndrome: comment on the article by Pillemer et al.
Topics: Clinical Trials as Topic; Dehydroepiandrosterone; Humans; Pilot Projects; Sjogren's Syndrome | 2005 |
Dehydroepiandrosterone versus placebo for Sjögren's syndrome: comment on the article by Pillemer et al.
Topics: Clinical Trials as Topic; Dehydroepiandrosterone; Humans; Sjogren's Syndrome | 2005 |
Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjögren's syndrome.
Topics: Adult; Dehydroepiandrosterone; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression; Humans; I | 2007 |