dehydroepiandrosterone has been researched along with Sicca Syndrome in 15 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum levels of the sex steroid prohormones dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) decline upon aging and are reduced in primary Sjogren's syndrome." | 9.14 | Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. ( Carlsten, H; Forsblad-d'Elia, H; Konttinen, YT; Labrie, F; Ohlsson, C, 2009) |
| "Primary Sjögren's syndrome (SS) is characterized by fatigue and low levels of serum dehydroepiandrosterone/dehydroepiandrosterone sulfate (DHEA/DHEAS)." | 9.14 | Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjögren's syndrome. ( Forsblad-d'Elia, H; Konttinen, YT; Porola, P; Solovieva, SA; Valtysdottir, S; Virkki, LM, 2010) |
| "Dehydroepiandrosterone (DHEA) administration has been reported to improve fatigue, psychological distress, and physical disability." | 9.13 | Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. ( Bijlsma, JW; Bootsma, H; Derksen, RH; Geenen, R; Godaert, GL; Hartkamp, A; Kruize, AA, 2008) |
| "Serum levels of the sex steroid prohormones dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) decline upon aging and are reduced in primary Sjogren's syndrome." | 5.14 | Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. ( Carlsten, H; Forsblad-d'Elia, H; Konttinen, YT; Labrie, F; Ohlsson, C, 2009) |
| "Primary Sjögren's syndrome (SS) is characterized by fatigue and low levels of serum dehydroepiandrosterone/dehydroepiandrosterone sulfate (DHEA/DHEAS)." | 5.14 | Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjögren's syndrome. ( Forsblad-d'Elia, H; Konttinen, YT; Porola, P; Solovieva, SA; Valtysdottir, S; Virkki, LM, 2010) |
| "Dehydroepiandrosterone (DHEA) administration has been reported to improve fatigue, psychological distress, and physical disability." | 5.13 | Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial. ( Bijlsma, JW; Bootsma, H; Derksen, RH; Geenen, R; Godaert, GL; Hartkamp, A; Kruize, AA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (66.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Konttinen, YT | 8 |
| Stegajev, V | 1 |
| Al-Samadi, A | 1 |
| Porola, P | 7 |
| Hietanen, J | 2 |
| Ainola, M | 1 |
| Boström, EA | 1 |
| d'Elia, HF | 1 |
| Dahlgren, U | 1 |
| Simark-Mattsson, C | 1 |
| Hasséus, B | 1 |
| Carlsten, H | 2 |
| Tarkowski, A | 1 |
| Bokarewa, M | 1 |
| Virkki, L | 1 |
| Przybyla, BD | 2 |
| Laine, M | 3 |
| Patterson, TA | 1 |
| Pihakari, A | 2 |
| Forsblad-d'Elia, H | 2 |
| Labrie, F | 1 |
| Ohlsson, C | 1 |
| Virkki, LM | 2 |
| Valtysdottir, S | 1 |
| Solovieva, SA | 1 |
| Virtanen, I | 1 |
| Pöllänen, R | 1 |
| Straub, RH | 1 |
| Nordström, DC | 1 |
| Fuellen, G | 1 |
| Bing, Y | 1 |
| Stegaev, V | 1 |
| Trokovic, N | 1 |
| Falk, SS | 1 |
| Liu, Y | 1 |
| Szodoray, P | 1 |
| Takakubo, Y | 1 |
| Brennan, MT | 2 |
| Sankar, V | 2 |
| Leakan, RA | 2 |
| Grisius, MM | 1 |
| Collins, MT | 1 |
| Fox, PC | 2 |
| Baum, BJ | 1 |
| Pillemer, SR | 2 |
| Smith, JA | 1 |
| Grisius, M | 1 |
| Ligier, S | 1 |
| Radfar, L | 1 |
| Kok, MR | 1 |
| Kingman, A | 1 |
| Toivanen, A | 1 |
| van Vollenhoven, R | 1 |
| Hartkamp, A | 1 |
| Geenen, R | 1 |
| Godaert, GL | 1 |
| Bootsma, H | 1 |
| Kruize, AA | 1 |
| Bijlsma, JW | 1 |
| Derksen, RH | 1 |
| Udby, L | 1 |
| Kjeldsen, L | 1 |
| Cowland, JB | 1 |
| Borregaard, N | 1 |
| Ståhle, M | 1 |
| Tóth, E | 1 |
| Horváth, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue[NCT00543166] | Phase 4 | 107 participants (Actual) | Interventional | 2003-02-28 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dehydroepiandrosterone and Sicca Syndrome
| Article | Year |
|---|---|
Sjögren's syndome and extragonadal sex steroid formation: a clue to a better disease control?
Topics: Androgens; Autoimmunity; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dendritic Cells; Di | 2015 |
Sex steroids in Sjögren's syndrome.
Topics: Acinar Cells; Animals; Apoptosis; Dehydroepiandrosterone; Dihydrotestosterone; Estrogens; Exocrine G | 2012 |
[The role of adrenal and gonadal hormones in the pathogenesis of autoimmune polyarthritis].
Topics: Androgens; Arthritis; Arthritis, Rheumatoid; Autoantigens; Chronic Disease; Dehydroepiandrosterone; | 2002 |
6 trials available for dehydroepiandrosterone and Sicca Syndrome
| Article | Year |
|---|---|
Salivary resistin reflects local inflammation in Sjögren's syndrome.
Topics: Adjuvants, Immunologic; Adult; Aged; Biomarkers; Case-Control Studies; Dehydroepiandrosterone; Femal | 2008 |
Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Dehydroepiandrosterone; Double-Blind | 2009 |
Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjögren's syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Dehydroepiandrosterone; Fatigue; Fem | 2010 |
Failure of oral DHEA treatment to increase local salivary androgen outputs of female patients with Sjögren's syndrome.
Topics: Adult; Aged; Androgens; Dehydroepiandrosterone; Female; Hormone Replacement Therapy; Humans; Middle | 2011 |
Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjögren's syndrome.
Topics: Adjuvants, Immunologic; Dehydroepiandrosterone; Double-Blind Method; Female; Humans; Middle Aged; Pi | 2004 |
Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial.
Topics: Adult; Affect; Aged; Blood Sedimentation; Chi-Square Distribution; Dehydroepiandrosterone; Dehydroep | 2008 |
6 other studies available for dehydroepiandrosterone and Sicca Syndrome
| Article | Year |
|---|---|
Androgen deficiency and defective intracrine processing of dehydroepiandrosterone in salivary glands in Sjögren's syndrome.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adult; Aged; Androgens; Biopsy; | 2008 |
Androgens and integrins in salivary glands in Sjogren's syndrome.
Topics: Adolescent; Adult; Aged; Biopsy; Cell Line; Dehydroepiandrosterone; Female; Gene Expression; Humans; | 2010 |
Sex steroid hormones in primary Sjögren's syndrome.
Topics: Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estrad | 2003 |
Pilot clinical trial of dehydroepiandrosterone for Sjögren's syndrome: comment on the article by Pillemer et al.
Topics: Clinical Trials as Topic; Dehydroepiandrosterone; Humans; Pilot Projects; Sjogren's Syndrome | 2005 |
Dehydroepiandrosterone versus placebo for Sjögren's syndrome: comment on the article by Pillemer et al.
Topics: Clinical Trials as Topic; Dehydroepiandrosterone; Humans; Sjogren's Syndrome | 2005 |
Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjögren's syndrome.
Topics: Adult; Dehydroepiandrosterone; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression; Humans; I | 2007 |