dehydroepiandrosterone has been researched along with Sepsis in 23 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently the benefit of subcutaneously applied dehydroepiandrosterone (DHEA) during sepsis was demonstrated." | 7.80 | Androstenediol modulates sepsis induced alterations of survival and immune functions in a murine model of sepsis. ( Lendemans, S; Oberbeck, R; Schmitz, D, 2014) |
| "Dehydroepiandrosterone (DHEA) was shown to improve the immune function and survival in experimental sepsis." | 7.80 | Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis. ( Al-Banna, N; Bac, VH; Balzer, C; Jaskulski, M; Lehmann, C; Nedeljkov, V; Pavlovic, D; Sharawi, N; Weber, S, 2014) |
| "Administration of dehydroepiandrosterone (DHEA) has been demonstrated to improve survival and cellular immune functions during systemic inflammation." | 7.76 | Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration. ( Hammes, F; Kobbe, P; Oberbeck, R; Schmitz, D; Wegner, A, 2010) |
| "The pathogenesis of sepsis is still undetermined to a large extent." | 5.32 | The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model. ( Hildebrand, F; Hoevel, P; Krettek, C; Pape, HC; van Griensven, M, 2003) |
| "Sepsis is associated with a marked depression of cellular immune function." | 5.31 | Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. ( Dahlweid, M; Emmendörfer, A; Koch, R; Oberbeck, R; Pape, HC; Tscherne, H; van Griensven, M, 2001) |
| "At 24 hours after trauma-hemorrhage and resuscitation, the animals were killed and blood, spleens, and peritoneal macrophages were harvested." | 5.30 | Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage. ( Angele, MK; Ayala, A; Bland, KI; Catania, RA; Chaudry, IH; Cioffi, WG, 1998) |
| "Recently the benefit of subcutaneously applied dehydroepiandrosterone (DHEA) during sepsis was demonstrated." | 3.80 | Androstenediol modulates sepsis induced alterations of survival and immune functions in a murine model of sepsis. ( Lendemans, S; Oberbeck, R; Schmitz, D, 2014) |
| "Dehydroepiandrosterone (DHEA) was shown to improve the immune function and survival in experimental sepsis." | 3.80 | Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis. ( Al-Banna, N; Bac, VH; Balzer, C; Jaskulski, M; Lehmann, C; Nedeljkov, V; Pavlovic, D; Sharawi, N; Weber, S, 2014) |
| "Administration of dehydroepiandrosterone (DHEA) has been demonstrated to improve survival and cellular immune functions during systemic inflammation." | 3.76 | Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration. ( Hammes, F; Kobbe, P; Oberbeck, R; Schmitz, D; Wegner, A, 2010) |
| "Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood." | 3.75 | DHEA-dependent and organ-specific regulation of TNF-alpha mRNA expression in a murine polymicrobial sepsis and trauma model. ( Barkhausen, T; Hildebrand, F; Krettek, C; van Griensven, M, 2009) |
| "Dehydroepiandrosterone (DHEA) exerts a variety of positive effects on the immunologic alterations after trauma and sepsis." | 3.71 | Dehydroepiandrosterone (DHEA) modulates the activity and the expression of lymphocyte subpopulations induced by cecal ligation and puncture. ( Böttcher, F; Breddin, M; Dahlweid, FM; Giannoudis, PV; Pape, HC; van Griensven, M; Wittwer, T, 2002) |
| "Prednisone may be immunosuppressive and dehydroepiandrosterone may stimulate the immune response, but their effect on gut-origin sepsis caused by bacterial translocation has not been studied." | 3.69 | Steroid therapy can modulate gut barrier function, host defense, and survival in thermally injured mice. ( Alexander, JW; Fukushima, R; Gianotti, L; Pyles, T, 1996) |
| "The clinical course after multiple trauma depends on the balance or imbalance of the pro- and anti-inflammatory immune response." | 2.47 | Immunomodulation in polytrauma and polymicrobial sepsis - where do we stand? ( Andruszkow, H; Frink, M; Hildebrand, F; Krettek, C; Mommsen, P; Neunaber, C; Zeckey, C, 2011) |
| "The pathogenesis of sepsis is still undetermined to a large extent." | 1.32 | The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model. ( Hildebrand, F; Hoevel, P; Krettek, C; Pape, HC; van Griensven, M, 2003) |
| "Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role." | 1.32 | Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents. ( Harwood, P; Hildebrand, F; Krettek, C; Pape, HC; van Griensven, M; Wittwer, T, 2004) |
| "Sepsis is associated with a marked depression of cellular immune function." | 1.31 | Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. ( Dahlweid, M; Emmendörfer, A; Koch, R; Oberbeck, R; Pape, HC; Tscherne, H; van Griensven, M, 2001) |
| "At 24 hours after trauma-hemorrhage and resuscitation, the animals were killed and blood, spleens, and peritoneal macrophages were harvested." | 1.30 | Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage. ( Angele, MK; Ayala, A; Bland, KI; Catania, RA; Chaudry, IH; Cioffi, WG, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schmitz, D | 4 |
| Lendemans, S | 1 |
| Oberbeck, R | 6 |
| Al-Banna, N | 1 |
| Pavlovic, D | 1 |
| Sharawi, N | 1 |
| Bac, VH | 1 |
| Jaskulski, M | 1 |
| Balzer, C | 1 |
| Weber, S | 1 |
| Nedeljkov, V | 1 |
| Lehmann, C | 1 |
| Barkhausen, T | 2 |
| Hildebrand, F | 5 |
| Krettek, C | 5 |
| van Griensven, M | 6 |
| Kobbe, P | 4 |
| Zeckey, C | 2 |
| Hoevel, P | 2 |
| Müller, K | 1 |
| Wegner, A | 2 |
| Hammes, F | 2 |
| Neunaber, C | 1 |
| Andruszkow, H | 1 |
| Frink, M | 1 |
| Mommsen, P | 1 |
| Dahlweid, FM | 1 |
| Giannoudis, PV | 1 |
| Wittwer, T | 2 |
| Böttcher, F | 1 |
| Breddin, M | 1 |
| Pape, HC | 4 |
| Marx, C | 1 |
| Petros, S | 1 |
| Bornstein, SR | 1 |
| Weise, M | 1 |
| Wendt, M | 1 |
| Menschikowski, M | 1 |
| Engelmann, L | 1 |
| Höffken, G | 1 |
| Kirk-Bayley, J | 1 |
| Venn, R | 1 |
| KOELBLOVA, V | 1 |
| GREGOROVA, I | 1 |
| KOELBEL, F | 1 |
| SONKA, J | 1 |
| Harwood, P | 1 |
| Frantz, MC | 2 |
| Prix, NJ | 1 |
| Wichmann, MW | 1 |
| van den Engel, NK | 1 |
| Hernandez-Richter, T | 1 |
| Faist, E | 1 |
| Chaudry, IH | 4 |
| Jauch, KW | 1 |
| Angele, MK | 3 |
| Matsuda, A | 1 |
| Furukawa, K | 1 |
| Suzuki, H | 1 |
| Matsutani, T | 1 |
| Tajiri, T | 1 |
| Deckert, H | 1 |
| Bangen, J | 1 |
| Gianotti, L | 1 |
| Alexander, JW | 2 |
| Fukushima, R | 1 |
| Pyles, T | 1 |
| Gennari, R | 1 |
| Ottaway, CA | 1 |
| Fong, IW | 1 |
| da Silva, B | 1 |
| Singer, W | 1 |
| Karrass, L | 1 |
| Catania, RA | 1 |
| Ayala, A | 1 |
| Cioffi, WG | 1 |
| Bland, KI | 1 |
| Dahlweid, M | 1 |
| Koch, R | 1 |
| Emmendörfer, A | 1 |
| Tscherne, H | 1 |
4 reviews available for dehydroepiandrosterone and Sepsis
| Article | Year |
|---|---|
Dehydroepiandrosterone (DHEA): a steroid with multiple effects. Is there any possible option in the treatment of critical illness?
Topics: Animals; Central Nervous System; Critical Illness; Dehydroepiandrosterone; Humans; Mice; Sepsis; Sho | 2010 |
Immunomodulation in polytrauma and polymicrobial sepsis - where do we stand?
Topics: Androstenediol; Animals; Dehydroepiandrosterone; Finasteride; Flutamide; Humans; Immunomodulation; L | 2011 |
Recently published papers: inflammation, elucidation, manipulation?
Topics: Biomarkers; Dehydroepiandrosterone; Humans; Hydrocortisone; Inflammation; Respiration, Artificial; S | 2003 |
Gender and sex hormones influence the response to trauma and sepsis: potential therapeutic approaches.
Topics: Adjuvants, Immunologic; Androgen Receptor Antagonists; Androgens; Blood Circulation; Dehydroepiandro | 2006 |
19 other studies available for dehydroepiandrosterone and Sepsis
| Article | Year |
|---|---|
Androstenediol modulates sepsis induced alterations of survival and immune functions in a murine model of sepsis.
Topics: Administration, Intravenous; Androstenediol; Animals; Apoptosis; Body Temperature; Cytokines; Dehydr | 2014 |
Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis.
Topics: Animals; Capillaries; Cell Adhesion; Chemotaxis, Leukocyte; Cytokines; Dehydroepiandrosterone; Disea | 2014 |
DHEA-dependent and organ-specific regulation of TNF-alpha mRNA expression in a murine polymicrobial sepsis and trauma model.
Topics: Animals; Base Sequence; Dehydroepiandrosterone; Disease Models, Animal; DNA Primers; Femoral Fractur | 2009 |
Activity of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment in IL-6 knockout mice.
Topics: Adjuvants, Immunologic; Animals; CD8-Positive T-Lymphocytes; Dehydroepiandrosterone; Disease Models, | 2010 |
Dehydroepiandrosterone during sepsis: does the timing of administration influence the effectiveness.
Topics: Animals; Critical Illness; Dehydroepiandrosterone; Interleukin-1beta; Interleukin-6; Lymphocyte Acti | 2010 |
Dehydroepiandrosterone modulates survival and immune functions during sepsis depending on the way of drug administration.
Topics: Animals; Apoptosis; Cell Proliferation; Cytokines; Dehydroepiandrosterone; Disease Models, Animal; D | 2010 |
Dehydroepiandrosterone (DHEA) modulates the activity and the expression of lymphocyte subpopulations induced by cecal ligation and puncture.
Topics: Adjuvants, Immunologic; Animals; CD8-Positive T-Lymphocytes; Dehydroepiandrosterone; Disease Models, | 2002 |
Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol.
Topics: Adrenocorticotropic Hormone; Age Factors; Aged; APACHE; C-Reactive Protein; Calcitonin; Dehydroepian | 2003 |
[CHANGES IN THE EXCRETION OF DEHYDROEPIANDROSTERONE IN PREGNANCY].
Topics: 17-Ketosteroids; Dehydroepiandrosterone; Female; Humans; Pregnancy; Sepsis; Toxemia; Urine | 1964 |
The importance of systemic cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model.
Topics: Adjuvants, Immunologic; Animals; Antigens, CD; Cytokines; Dehydroepiandrosterone; Interleukin-1; Int | 2003 |
Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents.
Topics: Animals; Body Temperature; Body Weight; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dehy | 2004 |
Dehydroepiandrosterone restores depressed peripheral blood mononuclear cell function following major abdominal surgery via the estrogen receptors.
Topics: Abdomen; Adjuvants, Immunologic; Adult; Aged; Cells, Cultured; Cytokines; Dehydroepiandrosterone; Es | 2005 |
Dehydroepiandrosterone modulates toll-like receptor expression on splenic macrophages of mice after severe polymicrobial sepsis.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Cell Membrane; Dehydroepiandrosterone; DN | 2005 |
Dehydroepiandrosterone: a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; HSP70 Heat-Shock Proteins; Immunity, Cellul | 2007 |
Steroid therapy can modulate gut barrier function, host defense, and survival in thermally injured mice.
Topics: Animals; Bacterial Translocation; Burns; Dehydroepiandrosterone; Digestive System; Escherichia coli; | 1996 |
Arginine, glutamine, and dehydroepiandrosterone reverse the immunosuppressive effect of prednisone during gut-derived sepsis.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Bacterial Translocation; Dehydroepiandrosterone; Evalua | 1997 |
Integrative aspects of a human model of endotoxemia.
Topics: Adrenocorticotropic Hormone; Cytokines; Dehydroepiandrosterone; Hormones; Humans; Hydrocortisone; In | 1998 |
Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage.
Topics: Adjuvants, Immunologic; Animals; Dehydroepiandrosterone; Hemorrhage; Macrophages; Male; Mice; Mice, | 1998 |
Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis.
Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Dehydroepiandrosterone; Disease Models, Anima | 2001 |