dehydroepiandrosterone has been researched along with Rheumatoid Arthritis in 57 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dehydroepiandrosterone (DHEA) treatment provides diverse anti-inflammatory benefits in rodent models of diseases, including rheumatoid arthritis (RA), but only limited benefits to patients." | 7.75 | An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. ( Auci, DL; Boyle, DL; Firestein, GS; Frincke, JM; Garsd, A; Offner, H; Pieters, R; Reading, CL; White, SK, 2009) |
| "We investigated conversion of the ubiquitous dehydroepiandrosterone sulfate (DHEAS), the biologically inactive precursor of DHEA, to the androgen DHEA in mixed synovial cells from patients with RA and patients with osteoarthritis (OA), making use of thin-layer chromatography and phosphorimaging." | 7.73 | Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency. ( Schmidt, M; Schölmerich, J; Straub, RH; Struharova, S; Ugele, B; Weidler, C, 2005) |
| "In patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), low levels of adrenal steroids have been repeatedly demonstrated, but the site of alteration has not been exactly described because measurements of serum pregnenolone and 17-hydroxypregnenolone (17OHPreg) together with other adrenal steroids have never been performed." | 7.72 | Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones. ( Dorner, M; Falk, W; Schölmerich, J; Straub, RH; Vogl, D, 2003) |
| "The sex hormones dehydroepiandrosterone sulphate (DHEAS), oestradiol, and sex hormone binding globulin (SHBG) were measured in 185 postmenopausal women (aged 45-65 years) with rheumatoid arthritis (RA) and related to assessments of bone mineral density at the spine and proximal femur." | 7.68 | Depressed levels of dehydroepiandrosterone sulphate in postmenopausal women with rheumatoid arthritis but no relation with axial bone density. ( Hall, GM; Perry, LA; Spector, TD, 1993) |
| "Dehydroepiandrosterone (DHEA) was converted into androstenediol, androstenedione (ASD), 16alphaOH-DHEA, 7alphaOH-DHEA, testosterone, estrone (E1), estradiol (E2), estriol (E3), and 16alphaOH-testosterone (similar in OA and RA)." | 5.33 | Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. ( Anders, S; Naumann, H; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2005) |
| " The conversion of dehydroepiandrosterone (DHEA) in target macrophages leads to an increase of downstream effector hormones (including estrogens), which may be an important factor for local immunomodulation at least in RA synovitis." | 4.82 | Synovial fluid estrogens in rheumatoid arthritis. ( Capellino, S; Cutolo, M; Montagna, P; Seriolo, B; Straub, RH; Sulli, A; Villaggio, B, 2004) |
| "7α-Hydroxy dehydroepiandrosterone (7α-OH-prasterone, 7α-OH-DHEA) is a key steroid intermediate in the synthesis of valuable pharmaceuticals widely used in the treatment of autoimmune illness, rheumatoid arthritis, colitis, and other severe diseases." | 4.31 | Selective Microbial Conversion of DHEA into 7α-OH-DHEA. ( Donova, MV; Kollerov, VV; Shutov, AA, 2023) |
| "Dehydroepiandrosterone (DHEA) treatment provides diverse anti-inflammatory benefits in rodent models of diseases, including rheumatoid arthritis (RA), but only limited benefits to patients." | 3.75 | An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. ( Auci, DL; Boyle, DL; Firestein, GS; Frincke, JM; Garsd, A; Offner, H; Pieters, R; Reading, CL; White, SK, 2009) |
| "The interrelations among adrenal steroids: cortisol (CORT), 17alpha-hydroxyprogesterone (17-OHP), androstenedione (ASD), dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) were evaluated in 15 glucocorticoid-naïve premenopausal females with RA and in 14 age- and body mass index- matched healthy females at basal and during insulin-induced hypoglycemia states." | 3.75 | Adrenal plasma steroid relations in glucocorticoid-naïve premenopausal rheumatoid arthritis patients during insulin-induced hypoglycemia test compared to matched normal control females. ( Aldag, JC; Imrich, R; Masi, AT; Rovensky, J; Vigas, M, 2009) |
| "We investigated conversion of the ubiquitous dehydroepiandrosterone sulfate (DHEAS), the biologically inactive precursor of DHEA, to the androgen DHEA in mixed synovial cells from patients with RA and patients with osteoarthritis (OA), making use of thin-layer chromatography and phosphorimaging." | 3.73 | Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency. ( Schmidt, M; Schölmerich, J; Straub, RH; Struharova, S; Ugele, B; Weidler, C, 2005) |
| "In patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), low levels of adrenal steroids have been repeatedly demonstrated, but the site of alteration has not been exactly described because measurements of serum pregnenolone and 17-hydroxypregnenolone (17OHPreg) together with other adrenal steroids have never been performed." | 3.72 | Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones. ( Dorner, M; Falk, W; Schölmerich, J; Straub, RH; Vogl, D, 2003) |
| "The endogenous steroid dehydroepiandrosterone (DHEA) has been reported to play a role in rheumatoid arthritis (RA)." | 3.72 | Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta. ( Bagchus, WM; Boots, AM; Dulos, J; Kaptein, A; Verbraak, E, 2004) |
| " Fifteen non-CNS-SLE patients, 15 RA patients and 15 HC participants similar in age, education, and gender (female) were compared on tests of cognition, depression, and plasma levels of interleukin-6 (IL-6), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) and cortisol." | 3.71 | Inflammatory and hormonal measures predict neuropsychological functioning in systemic lupus erythematosus and rheumatoid arthritis patients. ( Kozora, E; Laudenslager, M; Lemieux, A; West, SG, 2001) |
| "The sex hormones dehydroepiandrosterone sulphate (DHEAS), oestradiol, and sex hormone binding globulin (SHBG) were measured in 185 postmenopausal women (aged 45-65 years) with rheumatoid arthritis (RA) and related to assessments of bone mineral density at the spine and proximal femur." | 3.68 | Depressed levels of dehydroepiandrosterone sulphate in postmenopausal women with rheumatoid arthritis but no relation with axial bone density. ( Hall, GM; Perry, LA; Spector, TD, 1993) |
| "To investigate the effect of low doses of 2 different glucocorticoids on bone mass, sex hormone status and bone metabolic indices, a study was undertaken in 16 postmenopausal women with rheumatoid arthritis (RA) receiving < 15 mg/day of deflazacort and in 16 patients with RA matched for age, years postmenopause and disease duration, receiving < 10 mg/day of prednisone." | 3.68 | Sex hormones and bone metabolism in postmenopausal rheumatoid arthritis treated with two different glucocorticoids. ( Caporali, R; Caprotti, M; Caprotti, P; Montecucco, C; Notario, A, 1992) |
| "Dehydroepiandrosterone sulfate (DHEAS), testosterone, androstenedione, 17-beta estradiol and sex hormone binding globulin have been assayed in 50 HLA-identical postmenopausal rheumatoid arthritis (RA) discordant sibling pairs." | 3.68 | Sex hormones in postmenopausal HLA-identical rheumatoid arthritis discordant sibling pairs. ( Deighton, CM; Walker, DJ; Watson, MJ, 1992) |
| "Pregnanetriol excretion was lower (P less than ." | 2.37 | Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion. ( Jefferson, WE; Josipović, DB; Masi, AT, 1984) |
| "Future studies on primary hypothyroidism should focus on role of lower DHEAS levels in inducing symptoms of fatigue and joint pains." | 1.62 | Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism. ( Agarwal, M; Ganeshani, M; Jangir, R; Kandel, G; Sankanagoudar, S; Shukla, R; Srivastava, S, 2021) |
| "Dehydroepiandrosterone (DHEA) was converted into androstenediol, androstenedione (ASD), 16alphaOH-DHEA, 7alphaOH-DHEA, testosterone, estrone (E1), estradiol (E2), estriol (E3), and 16alphaOH-testosterone (similar in OA and RA)." | 1.33 | Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. ( Anders, S; Naumann, H; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2005) |
| "In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), patients demonstrate low levels of adrenal hormones." | 1.32 | Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. ( Demmel, B; Herrmann, M; Kees, F; Schedel, J; Schmidt, M; Schölmerich, J; Straub, RH; Weidler, C, 2004) |
| "Our analyses suggest that chronic PTSD, particularly comorbid PTSD or complex PTSD, is associated with all of these conditions." | 1.32 | Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. ( Boscarino, JA, 2004) |
| "The etiology of rheumatoid arthritis has been elusive, but it finally seems to be explained by a combination of three factors: (i) a relatively mild deficiency of cortisol, the normal adrenocortical hormone that is essential for normal immunity but which has achieved a bad reputation because of the use of excessive dosages of it or its stronger derivatives, (ii) a deficiency of dehydro-epi-androsterone (DHEA), the chief androgen produced by the human adrenal cortex but which has been little studied, and (iii) infection by organisms such as mycoplasma, which have a relatively low virulence, are difficult to culture in the laboratory, and cause inflammation and destruction of tissue in periarticular and articular areas of immunocompromised hosts." | 1.30 | The etiology of rheumatoid arthritis. ( Jefferies, WM, 1998) |
| " Prednisolone therapy in 22 patients (mean dosage 8 mg/day) was associated with reductions in estrone and testosterone levels; however, DHEAS and femoral BMD were also decreased in RA patients who were not receiving corticosteroids." | 1.27 | Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis. ( Champion, GD; Eisman, JA; Pocock, NA; Sambrook, PN, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (12.28) | 18.7374 |
| 1990's | 13 (22.81) | 18.2507 |
| 2000's | 32 (56.14) | 29.6817 |
| 2010's | 2 (3.51) | 24.3611 |
| 2020's | 3 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Kollerov, VV | 1 |
| Shutov, AA | 1 |
| Donova, MV | 1 |
| Sandoughi, M | 1 |
| Kaykhaei, MA | 1 |
| Langarizadeh, E | 1 |
| Dashipour, A | 1 |
| Shukla, R | 1 |
| Ganeshani, M | 1 |
| Agarwal, M | 1 |
| Jangir, R | 1 |
| Kandel, G | 1 |
| Sankanagoudar, S | 1 |
| Srivastava, S | 1 |
| Offner, H | 1 |
| Firestein, GS | 1 |
| Boyle, DL | 1 |
| Pieters, R | 1 |
| Frincke, JM | 1 |
| Garsd, A | 1 |
| White, SK | 2 |
| Reading, CL | 2 |
| Auci, DL | 2 |
| Imrich, R | 3 |
| Vigas, M | 3 |
| Rovensky, J | 3 |
| Aldag, JC | 1 |
| Masi, AT | 3 |
| Mangano, K | 1 |
| Destiche, D | 1 |
| Huang, Y | 1 |
| Boyle, D | 1 |
| Frincke, J | 1 |
| Nicoletti, F | 1 |
| Lowin, T | 1 |
| Weidler, C | 5 |
| Jenei-Lanzl, Z | 1 |
| Capellino, S | 2 |
| Baerwald, CG | 1 |
| Buttgereit, F | 1 |
| Straub, RH | 12 |
| Josipovic, B | 1 |
| Josipovic, A | 1 |
| Härle, P | 2 |
| Cutolo, M | 7 |
| Schölmerich, J | 6 |
| Foppiani, L | 3 |
| Minuto, F | 1 |
| Vogl, D | 1 |
| Falk, W | 1 |
| Dorner, M | 1 |
| Harbuz, MS | 1 |
| Korendowych, E | 1 |
| Jessop, DS | 1 |
| Crown, AL | 1 |
| Li pdfan, SL | 1 |
| Kirwan, JR | 1 |
| UNGAR, F | 1 |
| MILLER, AM | 1 |
| DORFMAN, RI | 1 |
| Tengstrand, B | 2 |
| Carlström, K | 2 |
| Felländer-Tsai, L | 1 |
| Hafström, I | 2 |
| Castagnetta, LA | 1 |
| Carruba, G | 1 |
| Granata, OM | 1 |
| Stefano, R | 1 |
| Miele, M | 1 |
| Schmidt, M | 5 |
| Villaggio, B | 2 |
| Seriolo, B | 3 |
| Montagna, P | 1 |
| Sulli, A | 3 |
| Demmel, B | 1 |
| Herrmann, M | 1 |
| Kees, F | 1 |
| Schedel, J | 1 |
| Dulos, J | 3 |
| Verbraak, E | 1 |
| Bagchus, WM | 1 |
| Boots, AM | 2 |
| Kaptein, A | 2 |
| Chen, CC | 1 |
| Parker, CR | 1 |
| Boscarino, JA | 1 |
| van der Vleuten, MA | 1 |
| Kavelaars, A | 2 |
| Heijnen, CJ | 1 |
| Radikova, Z | 2 |
| Greguska, O | 2 |
| Macho, L | 2 |
| Struharova, S | 1 |
| Ugele, B | 1 |
| Naumann, H | 2 |
| Anders, S | 2 |
| Heijnen, C | 1 |
| Boots, A | 1 |
| Yamana, S | 1 |
| Matsuda, T | 1 |
| Takasugi, K | 1 |
| Kishimoto, T | 1 |
| Nishimoto, N | 1 |
| Schellenberg, M | 1 |
| Simorova, E | 1 |
| Ernestam, S | 1 |
| Werner, S | 1 |
| Sternberg, EM | 1 |
| Silverman, MN | 1 |
| Cizza, G | 1 |
| Blackman, MR | 1 |
| Muniyappa, R | 1 |
| Wilson, M | 1 |
| Moquin, BE | 1 |
| Baldwin, HL | 1 |
| Wong, KA | 1 |
| Snyder, C | 1 |
| Magalnick, M | 1 |
| Alli, S | 1 |
| Reynolds, J | 1 |
| Steinberg, SM | 1 |
| Goldbach-Mansky, R | 1 |
| Pongratz, G | 1 |
| Hirvonen, H | 1 |
| Pohjolainen, T | 1 |
| Mikkelsson, M | 1 |
| Leirisalo-Repo, M | 1 |
| Josipović, DB | 1 |
| Jefferson, WE | 1 |
| Dougados, M | 1 |
| Nahoul, K | 1 |
| Benhamou, L | 1 |
| Jungers, P | 1 |
| Laplane, D | 1 |
| Amor, B | 1 |
| Fehér, KG | 2 |
| Fehér, T | 2 |
| Mateo, L | 1 |
| Nolla, JM | 1 |
| Bonnin, MR | 1 |
| Navarro, MA | 1 |
| Roig-Escofet, D | 1 |
| Ferraccioli, G | 1 |
| Guerra, P | 1 |
| Rizzi, V | 1 |
| Bartoli, E | 1 |
| van den Brink, HR | 1 |
| van Wijk, MJ | 1 |
| Geertzen, RG | 1 |
| Bijlsma, JW | 1 |
| Hall, GM | 1 |
| Perry, LA | 1 |
| Spector, TD | 1 |
| Mirone, L | 1 |
| Altomonte, L | 1 |
| D'Agostino, P | 1 |
| Zoli, A | 1 |
| Barini, A | 1 |
| Magaro, M | 1 |
| Sessarego, P | 1 |
| Prete, C | 2 |
| Giusti, M | 3 |
| Giltay, EJ | 1 |
| van Schaardenburg, D | 1 |
| Gooren, LJ | 1 |
| von Blomberg, BM | 1 |
| Fonk, JC | 1 |
| Touw, DJ | 1 |
| Dijkmans, BA | 1 |
| Jefferies, WM | 1 |
| Ballarino, P | 1 |
| Accardo, S | 2 |
| Kanik, KS | 1 |
| Chrousos, GP | 1 |
| Schumacher, HR | 1 |
| Crane, ML | 1 |
| Yarboro, CH | 1 |
| Wilder, RL | 1 |
| Chatterton, RT | 1 |
| Zietz, B | 1 |
| Kozora, E | 1 |
| Laudenslager, M | 1 |
| Lemieux, A | 1 |
| West, SG | 1 |
| Schwartz, KE | 1 |
| Tóth, E | 1 |
| Horváth, C | 1 |
| Montecucco, C | 1 |
| Caporali, R | 1 |
| Caprotti, P | 1 |
| Caprotti, M | 1 |
| Notario, A | 1 |
| Deighton, CM | 1 |
| Watson, MJ | 1 |
| Walker, DJ | 1 |
| Sambrook, P | 1 |
| Birmingham, J | 1 |
| Champion, D | 1 |
| Kelly, P | 1 |
| Kempler, S | 1 |
| Freund, J | 1 |
| Eisman, J | 1 |
| Balleari, E | 1 |
| Intra, E | 1 |
| Merétey, K | 1 |
| Sambrook, PN | 1 |
| Eisman, JA | 1 |
| Champion, GD | 1 |
| Pocock, NA | 1 |
| Carter, ME | 1 |
| James, VH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Suppression of the Growth Hormone/ Insulin-Like Growth Factor-1 (GH/IGF-1) Axis in Women With Rheumatoid Arthritis[NCT00034060] | Phase 2 | 36 participants | Interventional | 2002-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for dehydroepiandrosterone and Rheumatoid Arthritis
| Article | Year |
|---|---|
[Rheumatoid arthritis - pathogenetic role of neuroendocrine axes and the peripheral nervous system].
Topics: Androgens; Arthritis, Rheumatoid; Dehydroepiandrosterone; Feedback; Humans; Hydrocortisone; Hypothal | 2002 |
Synovial fluid estrogens in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; Cytokines; Dehydroepiandrosterone; Estriol; Estrogens; Female; | 2004 |
Adrenal androgens and the immune system.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Glands; Androgens; Animals; Arthritis, Rheumatoid; Criti | 2004 |
Inflammation and sex hormone metabolism.
Topics: Androgens; Animals; Arthritis, Rheumatoid; Dehydroepiandrosterone; Estrogens; Humans; Inflammation; | 2006 |
Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Anab | 1984 |
Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Arthritis, Rheumatoid; Cytokines; Deh | 2000 |
Autoimmunity, dehydroepiandrosterone (DHEA), and stress.
Topics: Adjuvants, Immunologic; Apoptosis; Arthritis, Rheumatoid; Cytokines; Dehydroepiandrosterone; Humans; | 2002 |
[The role of adrenal and gonadal hormones in the pathogenesis of autoimmune polyarthritis].
Topics: Androgens; Arthritis; Arthritis, Rheumatoid; Autoantigens; Chronic Disease; Dehydroepiandrosterone; | 2002 |
7 trials available for dehydroepiandrosterone and Rheumatoid Arthritis
| Article | Year |
|---|---|
Effects of dehydroepiandrosterone on quality of life in premenopausal women with rheumatoid arthritis: A preliminary randomized clinical trial.
Topics: Adjuvants, Immunologic; Adult; Arthritis, Rheumatoid; Dehydroepiandrosterone; Double-Blind Method; F | 2020 |
Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Androgens; A | 2006 |
Acute cold stress in rheumatoid arthritis inadequately activates stress responses and induces an increase of interleukin 6.
Topics: Androstenedione; Arthritis, Rheumatoid; Biomarkers; Cryotherapy; Dehydroepiandrosterone; Female; Glu | 2009 |
Cyclosporin A increases somatomedin C insulin-like growth factor I levels in chronic rheumatic diseases.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Cyclosporine; Dehydroepiandrosterone; Dehydroepiandrost | 1995 |
Desmopressin and low-dose ACTH test in rheumatoid arthritis.
Topics: Adrenocorticotropic Hormone; Adult; Animals; Arthritis, Rheumatoid; Cohort Studies; Corticotropin-Re | 1998 |
Effects of dehydroepiandrosterone administration on disease activity in patients with rheumatoid arthritis.
Topics: Administration, Oral; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cells, Cultured; Dehydroepiand | 1998 |
Androgen replacement therapy in male patients with rheumatoid arthritis.
Topics: Administration, Oral; Aged; Androgens; Arthritis, Rheumatoid; Dehydroepiandrosterone; Follicle Stimu | 1991 |
42 other studies available for dehydroepiandrosterone and Rheumatoid Arthritis
| Article | Year |
|---|---|
Selective Microbial Conversion of DHEA into 7α-OH-DHEA.
Topics: Arthritis, Rheumatoid; Colitis; Dehydroepiandrosterone; Ethanol; Humans; Hydroxylation | 2023 |
Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism.
Topics: Aged; Arthritis, Rheumatoid; Dehydroepiandrosterone; Female; Humans; Hypothyroidism; Male; Retrospec | 2021 |
An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Antibody Formation; Arthritis, Rheumatoid; Collagen; | 2009 |
Adrenal plasma steroid relations in glucocorticoid-naïve premenopausal rheumatoid arthritis patients during insulin-induced hypoglycemia test compared to matched normal control females.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex Hormones; Adult; Androstenedione; Arthritis, Rheumatoid | 2009 |
Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Body Weight; Dehydroe | 2010 |
Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis.
Topics: Aged; Aromatase; Arthritis, Rheumatoid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Fema | 2012 |
Basal levels of DHEAS as a marker for disease activity in premenopausal women with recent onset rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Biomarkers; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Jo | 2002 |
Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumatica.
Topics: 17-alpha-Hydroxyprogesterone; Adrenocorticotropic Hormone; Adult; Aged; Animals; Arthritis, Rheumato | 2002 |
Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones.
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adult; Aged; Androstened | 2003 |
Hypothalamo-pituitary-adrenal axis dysregulation in patients with rheumatoid arthritis after the dexamethasone/corticotrophin releasing factor test.
Topics: Adrenocorticotropic Hormone; Arthritis, Rheumatoid; Case-Control Studies; Corticotropin-Releasing Ho | 2003 |
Metabolism of dehydroepiandrosterone and delta 5-androstene-3 beta, 17 beta-diol.
Topics: Androgens; Androstenes; Arthritis; Arthritis, Rheumatoid; Dehydroepiandrosterone; Humans; Lipid Meta | 1954 |
Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rheumatoid arthritis: high correlation between serum estradiol and current degree of inflammation.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Case-Control Studies; Dehydroepiandrosterone; | 2003 |
Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Adult; Androgens; Arthritis, Rheumatoid; Dehydroepiandrosterone; Estradiol; | 2003 |
Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex Hormones; Adult; Androstenedione; Arthritis, Rheumatoid | 2004 |
Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Blotting, Western; Chromatography, High Pre | 2004 |
Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Dehydroepiandrosterone; Diabetes Mellitus, Type 1; Femal | 2004 |
CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
Topics: Arthritis, Rheumatoid; Cell Line; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 7; Cytokine | 2005 |
Gonadal and adrenal steroid hormones in plasma and synovial fluid of patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aldosterone; Arthritis, Rheumatoid; Case-Control Studies; Dehy | 2004 |
Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency.
Topics: Aged; Arthritis, Rheumatoid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; | 2005 |
Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes--androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgens; Androstenedione; Aromatase; Arthritis, Rheumatoid; | 2005 |
Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b.
Topics: Arthritis, Rheumatoid; Base Sequence; Cell Line; Cytochrome P-450 Enzyme System; Cytochrome P450 Fam | 2005 |
Comparison of hormone transfer to pleural and synovial exudates.
Topics: Aged; Aldosterone; Arthritis, Rheumatoid; C-Peptide; Dehydroepiandrosterone; Estradiol; Exudates and | 2006 |
Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function.
Topics: Adrenal Glands; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthri | 2007 |
The neuroendocrine system and rheumatoid arthritis: insights from anti-tumor necrosis factor-alpha therapy.
Topics: Adrenal Cortex; Antibodies, Monoclonal; Arthritis, Rheumatoid; Biomarkers; Dehydroepiandrosterone; H | 2007 |
Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study.
Topics: Adult; Arthritis, Rheumatoid; Blood Chemical Analysis; Case-Control Studies; Circadian Rhythm; Dehyd | 2007 |
[Study of plasma androgens in women with autoimmune diseases].
Topics: Adolescent; Adult; Androgens; Androstenedione; Arthritis, Rheumatoid; Autoimmune Diseases; Dehydroep | 1984 |
Plasma dehydroepiandrosterone, dehydroepiandrosterone sulphate and androsterone sulphate levels and their interaction with plasma proteins in rheumatoid arthritis.
Topics: Adolescent; Adult; Androsterone; Arthritis, Rheumatoid; Blood Proteins; Dehydroepiandrosterone; Dehy | 1984 |
Sex hormone status and bone mineral density in men with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Aged; Androstenedione; Arthritis, Rheumatoid; Bone Density; Dehydroepiandro | 1995 |
Influence of corticosteroid pulse therapy on the serum levels of soluble interleukin 2 receptor, interleukin 6 and interleukin 8 in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Dehydroepiandrosterone; Dehydroepiandrosteron | 1994 |
Depressed levels of dehydroepiandrosterone sulphate in postmenopausal women with rheumatoid arthritis but no relation with axial bone density.
Topics: Aged; Arthritis, Rheumatoid; Bone Density; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; E | 1993 |
A study of serum androgen and cortisol levels in female patients with rheumatoid arthritis. Correlation with disease activity.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; Middle A | 1996 |
The etiology of rheumatoid arthritis.
Topics: Adrenal Cortex; Arthritis, Rheumatoid; Cartilage, Articular; Dehydroepiandrosterone; Humans; Hydroco | 1998 |
Hypothalamic-pituitary-adrenocortical axis function in premenopausal women with rheumatoid arthritis not treated with glucocorticoids.
Topics: Adrenocorticotropic Hormone; Adult; Arthritis, Rheumatoid; Corticotropin-Releasing Hormone; Dehydroe | 1999 |
Adrenocorticotropin, glucocorticoid, and androgen secretion in patients with new onset synovitis/rheumatoid arthritis: relations with indices of inflammation.
Topics: Adrenocorticotropic Hormone; Adult; Androgens; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactiv | 2000 |
Glucocorticoid-like anti-inflammatory versus immunosuppressive effects of CPH 82 as a single drug therapy of moderately active rheumatoid arthritis patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dehydroepiandrosterone; Glucocortico | 2000 |
Inflammatory and hormonal measures predict neuropsychological functioning in systemic lupus erythematosus and rheumatoid arthritis patients.
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Attention; Case-Control Studies; Cognition; | 2001 |
Sex hormones and bone metabolism in postmenopausal rheumatoid arthritis treated with two different glucocorticoids.
Topics: Adult; Aged; Aged, 80 and over; Androstenedione; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Bo | 1992 |
Sex hormones in postmenopausal HLA-identical rheumatoid arthritis discordant sibling pairs.
Topics: Aged; Aged, 80 and over; Androstenedione; Arthritis, Rheumatoid; Dehydroepiandrosterone; Dehydroepia | 1992 |
Postmenopausal bone loss in rheumatoid arthritis: effect of estrogens and androgens.
Topics: Androgens; Arthritis, Rheumatoid; Bone Density; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfa | 1992 |
Interrelationship between the immunological and steroid hormone parameters in rheumatoid arthritis.
Topics: Adolescent; Adult; Age Factors; Androgens; Arthritis, Rheumatoid; Autoantibodies; Dehydroepiandroste | 1986 |
Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Bone and Bones; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Femal | 1988 |
Comparison of effects of corticotrophin and corticosteroids on pituitary-adrenal function.
Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Androstanes; Arthritis; A | 1971 |