dehydroepiandrosterone has been researched along with Premenstrual Syndrome in 10 studies
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Premenstrual Syndrome: A combination of distressing physical, psychologic, or behavioral changes that occur during the luteal phase of the menstrual cycle. Symptoms of PMS are diverse (such as pain, water-retention, anxiety, cravings, and depression) and they diminish markedly 2 or 3 days after the initiation of menses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, double-blind, dose-response study, alpha-tocopherol significantly ameliorated symptoms in three of the four classes of the premenstrual syndrome (PMS)." | 2.65 | The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. II. Endocrine correlates. ( Goldstein, P; London, RS; Manimekalai, S; Murphy, L; Reynolds, M; Sundaram, G, 1984) |
| "Acne is an inflammatory process of follicle sebaceous unites." | 1.31 | [Correlations between acne and polycystic ovary. A study of 60 cases]. ( Iurassich, S; Pace, L; Palagiano, A; Trotta, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pluchino, N | 1 |
| Santoro, A | 1 |
| Casarosa, E | 2 |
| Wenger, JM | 1 |
| Genazzani, AD | 1 |
| Petignat, P | 1 |
| Genazzani, AR | 2 |
| Gao, H | 2 |
| Shang, YZ | 1 |
| Xia, T | 2 |
| Qiao, MQ | 2 |
| Zhang, HY | 1 |
| Ma, YX | 1 |
| Lombardi, I | 1 |
| Luisi, S | 1 |
| Quirici, B | 1 |
| Monteleone, P | 1 |
| Bernardi, F | 1 |
| Liut, M | 1 |
| Palumbo, M | 1 |
| Petraglia, F | 1 |
| Smith, MJ | 1 |
| Schmidt, PJ | 1 |
| Su, TP | 1 |
| Rubinow, DR | 2 |
| Tuveri, A | 1 |
| Paoletti, AM | 1 |
| Orrù, M | 1 |
| Melis, GB | 1 |
| Marotto, MF | 1 |
| Zedda, P | 1 |
| Marrosu, F | 1 |
| Sogliano, C | 1 |
| Marra, C | 1 |
| Biggio, G | 1 |
| Concas, A | 1 |
| London, RS | 1 |
| Sundaram, G | 1 |
| Manimekalai, S | 1 |
| Murphy, L | 1 |
| Reynolds, M | 1 |
| Goldstein, P | 1 |
| Iurassich, S | 1 |
| Trotta, C | 1 |
| Palagiano, A | 1 |
| Pace, L | 1 |
| Sondheimer, SJ | 1 |
| Freeman, EW | 1 |
| Scharlop, B | 1 |
| Rickels, K | 1 |
| Hoban, MC | 1 |
| Grover, GN | 1 |
| Galloway, DS | 1 |
| Roy-Byrne, P | 1 |
| Andersen, R | 1 |
| Merriam, GR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pituitary Gonadotropin Response to GnRH Stimulation in Menstrual, Climacteric and, Menopause-Related Mood and Behavioral Disorders[NCT00001232] | 140 participants | Observational | 1988-07-31 | Completed | |||
| The Treatment of Menstrually-Related Mood Disorders With Continuous Gonadal Steroid Replacement[NCT00005011] | 22 participants (Actual) | Observational | 2000-03-28 | Completed | |||
| The Treatment of Menstrually-Related Mood Disorders With the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)[NCT00001259] | Phase 1 | 60 participants (Actual) | Interventional | 1992-08-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Beck Depression Inventory (BDI) is a 21-item, self-report rating inventory that measures the severity of symptoms accompanying depression. Each item has a minimum score of 0 and a maximum score of 3, with higher numbers consistent with more severe symptoms. The score of each item is summed to amount the overall BDI score, with a minimum score of 0 and a maximum score of 63. Higher BDI scores are consistent with more severe depression. Score of 16 or greater is consistent with clinical depression.~Each participant completed the BDI every 2 weeks during each of the study phases throughout the 6-month study. Outcome measures reported consist of the average of two BDI scores from each phase of the study: the last 4 weeks of the GnRH agonist alone; weeks 6 and 8 of placebo alone; during the 4-week long estradiol phase (weeks 2 and 4 of estradiol) and the 4-week long progesterone phase (weeks 2 and 4 of progesterone)." (NCT00001259)
Timeframe: Placebo: Weeks 6 and 8 of Placebo; Lupron only: Weeks 6 and 8 or 10 and 12; Estradiol or progesterone: Weeks 2 and 4
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | 2.6 |
| GnRH Agonist Injections (Lupron-L Only) | 3.0 |
| Estradiol | 5.3 |
| Progesterone | 3.6 |
1 review available for dehydroepiandrosterone and Premenstrual Syndrome
| Article | Year |
|---|---|
Advances in neurosteroids: role in clinical practice.
Topics: Affect; Aging; Behavior; Brain Injuries; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone S | 2013 |
1 trial available for dehydroepiandrosterone and Premenstrual Syndrome
| Article | Year |
|---|---|
The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. II. Endocrine correlates.
Topics: Clinical Trials as Topic; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double-Blind Metho | 1984 |
8 other studies available for dehydroepiandrosterone and Premenstrual Syndrome
| Article | Year |
|---|---|
The correlation between neurosteroids and neurotransmitters with liver yang rising and liver qi stagnation types of premenstrual syndrome.
Topics: Adult; Dehydroepiandrosterone; Dopamine; Female; gamma-Aminobutyric Acid; Humans; Liver; Medicine, C | 2014 |
[Correlation between neurotransmitters and neurosteroids and premenstrual syndrome patients of Gan-yang ascending syndrome and Gan-qi stagnation syndrome].
Topics: Adult; Case-Control Studies; Dehydroepiandrosterone; Estradiol; Female; Follicular Phase; Humans; Lu | 2012 |
Adrenal response to adrenocorticotropic hormone stimulation in patients with premenstrual syndrome.
Topics: Adolescent; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Adult; Andro | 2004 |
Gonadotropin-releasing hormone-stimulated gonadotropin levels in women with premenstrual dysphoria.
Topics: Adult; Dehydroepiandrosterone; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Gonadotropi | 2004 |
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.
Topics: Adult; Anticonvulsants; Body Mass Index; Dehydroepiandrosterone; Desoxycorticosterone; Electroenceph | 2008 |
[Correlations between acne and polycystic ovary. A study of 60 cases].
Topics: Acne Vulgaris; Adult; Dehydroepiandrosterone; Estradiol; Female; Follicle Stimulating Hormone; Human | 2001 |
Hormonal changes in premenstrual syndrome.
Topics: Body Water; Dehydroepiandrosterone; Dexamethasone; Female; Hormones; Humans; Hydroxyindoleacetic Aci | 1985 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |
Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estradiol; Female; Foll | 1988 |